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Four new members of the SOCS (zeige CISH Proteine) family of molecules in rainbow trout (Oncorhynchus mykiss), CISH (zeige CISH Proteine) and SOCS6, 7 and 9, are described for the first time in this species
Together, our data provide important evidence for miR (zeige MLXIP Proteine)-19 mediated SOCS6 in OS growth and revealed miR (zeige MLXIP Proteine)-19/SOCS6/JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) pathway as a potential therapeutic strategy for OS patients.
Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples.
our results describe for the first time the role of miR (zeige MLXIP Proteine)-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients.
miR (zeige MLXIP Proteine)-142-3p regulates NPC (zeige NPC1 Proteine) development by down-regulating SOCS6 expression and suggest that modulation of miR (zeige MLXIP Proteine)-142-3p expression could be a therapeutic strategy for NPC (zeige NPC1 Proteine)
Stage-independent downregulation of SOCS2 (zeige SOCS2 Proteine) and SOCS6 correlate with disease-free survival in colorectal cancer.
Studied both the function of upregulated miR (zeige MLXIP Proteine)-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR (zeige MLXIP Proteine)-424-5p.
miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer
SOCS2 (zeige SOCS2 Proteine) and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis
Results show that SOCS6 forms complex with DRP1 (zeige CRMP1 Proteine) and the mitochondrial phosphatase PGAM5 (zeige PGAM5 Proteine), attenuates DRP1 (zeige CRMP1 Proteine) phosphorylation, and promotes DRP1 (zeige CRMP1 Proteine) mitochondrial translocation.
SOCS6 negatively regulates Flt3 (zeige FLT3 Proteine) activation, the downstream Erk (zeige EPHB2 Proteine) signaling pathway, and cell proliferation.
Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 (zeige DAB1 Proteine) and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 (zeige DAB1 Proteine) by SOCS6 and SOCS7 terminates reelin (zeige RELN Proteine) signaling and allows a new cycle of reelin (zeige RELN Proteine) signaling to commence. 3) Repeated cycles of reelin (zeige RELN Proteine) signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
Our results show that endogenous Cul5 (zeige CUL5 Proteine) suppresses epithelial cell transformation by several pathways, including inhibition of Src (zeige SRC Proteine)-Cas (zeige CTNND1 Proteine)-induced ruffling through SOCS6
SOCS-6 binds to insulin receptor substrate 4 (zeige IRS4 Proteine), and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
SOCS4 expression, in contrast, does not appear to be EPO (zeige EPO Proteine) inducible.SOCS4 is ineffective at counteracting EPO (zeige EPO Proteine)-mediated events.
SOCS6 has a role as a negative regulator of receptor tyrosine kinases
SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
TH1 (zeige HAND1 Proteine)-specific chromatin structure is created by early recruitment of Swi (zeige SMARCA1 Proteine)-SNF (zeige SNRPA Proteine) complexes and nucleosome remodeling dependent on Stat4 (zeige STAT4 Proteine).
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
suppressor of cytokine signaling 6
, suppressor of cytokine signaling
, hypothetical protein LOC100124796
, STAT induced STAT inhibitor-4
, cytokine-inducible SH2 protein 4
, suppressor of cytokine signaling 4
, SH2 domain containing SOCS box protein SOCS6
, cytokine inducible SH2-containing protein 4
, cytokine inducible SH2-containing protein CIS4