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This study identified 4 PRLR variations (p.Ile76Val, p.Ile146Leu, p.Glu108Lys and p.Glu554Gln) in 16 Sporadic Prolactinoma in Humans.
results highlight PRLR as an independent predictor of favorable prognosis in human breast cancer
Two markers for the PRL (zeige PRL Proteine) peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped.
The prolactin receptor is constitutively expressed on regulatory T and effector T cells in systemic lupus erythematosus patients, and this expression is higher than in healthy individuals.
There is a possible role for PRLR in the progression of cervical cancer.
PRL (zeige PRL Proteine)-PRLR can escalate the impact of breast cancer on bone metastasis and the presence of PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.
Study shows that position 146 plays a central role in directing intrinsic properties of the PRLR, including extracellular domain folding, PRL (zeige PRL Proteine)-responsiveness, and ligand-independent activity of the receptor.
Data suggest that (1) cell membrane/lipid bilayer binding of PRLR and (2) tyrosine phosphorylation of PRLR intracellular domain are independent.
long PRLR plays an important role in breast cancer metastasis.
a residue quartet in the extracellular membrane proximal domain of the homodimeric cytokine receptor (zeige EBI3 Proteine) prolactin receptor is a key regulator of intracellular signaling discrimination
The presence and localization of prolactin receptor are consistent with expression data reported for other species, and the presence of PIP (zeige PIP Proteine) and prolactin (zeige PRL Proteine) in seminal fluid is consistent with data generated in humans.
This study revealed for the first time that the PRLR gene is a promising candidate gene that affects growth traits in cattle.
determination of the effects of exposure to different lengths of daylight during the dry period on circulating PRL (zeige PRL Proteine) and PRL (zeige PRL Proteine) receptor mRNA expression in lymphocytes and mammary tissue during the transition to lactation
Alternative splicing of transcripts from nine first exons of the porcine PRLR (pPRLR) gene are differentially expressed in various tissues.
The effects of prolactin receptor and beta-casein (zeige CSN2 Proteine) genotype on the nutritive value of sow milk are reported.
PRLR was identified as down-regulated in the oviduct of immotile short tail sperm (ISTS) homozygous sows. The methylation pattern of the PRLR gene region appeared unaffected.
Associations between genotypes of the prolactin receptor (PRLR) gene and swine reproductive, growth and meat traits were determined.
A prolactin receptor short mRNA sequence that is encoded by exon 11 within the pPRLR gene is expressed most abundantly in several tissues known to be prolactin (zeige PRL Proteine) targets in pigs. The pPRLR-SF acts as a dominant negative to the pPRLR-LF.
Results showed that the effects of FSHb (zeige FSHB Proteine), ESR (zeige ESR1 Proteine), and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
found associations between PRLR genotype and ejaculate volume, sperm concentration, percentage of live sperm, and number of live sperm in the ejaculate
A report of greater than expected levels of amino acid variability within the intracellular domain of the porcine PRLR, which have been associated with differences in ovulation in sows and the preweaning survivability of piglets is presented.
Data showed that sows with genotype AB in PRLR gene had a significantly higher frequency of lateral-lying-to- other-posture trait and percentage of sow-terminated nursing trait than sows with the AA and BB genotypes.
The results showed that the polymorphic sites of both PRLR and RBP4 (zeige RBP4 Proteine) genes are closely related to litter size traits.
both species had very similar patterns of PRL (zeige PRL Proteine) release and expression of PRLR mRNA, and no major differences were observed between turkey or chicken embryos
Truncating mutations of Prlr promote tumor growth in a model of human ERalpha (zeige ESR1 Proteine)+ breast cancer.
MafB (zeige MAFB Proteine) deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy.
Of the four placenta-specific, Prl (zeige PRL Proteine)-related hormones that have been shown to interact with the Prlr, their gene expression localizes to different endocrine cell types
Prolactin (zeige PRL Proteine) transport into mouse brain is independent of prolactin receptor.
Prolactin receptor was upregulated in proximal kidney tubule cells of mice with cardiac disease.
This study showed in knockout mice showed no effect of PRL (zeige PRL Proteine) and PRL-R gene ablation on heat and cold hyperalgesia in male mice, while heat hyperlgesia were reduced 3-72 h post-surgery in female PRL (zeige PRL Proteine) and PRL-R knockout mice
The in utero environment of the Prlr(+/-) mother confers long-term changes in the pancreatic islets of her offspring such that when the offspring themselves became pregnant, they cannot adapt to the increased insulin (zeige INS Proteine) demands of their own pregnancy.
results provide direct genetic evidence that PRLR affects energy balance and metabolic adaptation in rodents via effects on brown adipose tissue differentiation and function
Germline knockout of prolactin (zeige PRL Proteine) or its receptor has failed to reveal a key role for prolactin (zeige PRL Proteine) signaling in mouse prostate physiology.
Data suggest that PRL (zeige PRL Proteine) stimulates the Prlr gene expression through the transcriptional activation of mE1 (zeige ME1 Proteine)(4) first exon, leading to increases in the long- and short-form variants of Prlr mRNA in the murine choroid plexus.
PRL (zeige PRL Proteine) receptor signaling exerts robust effects on lactotroph development and plays a permissive role in lactotroph osmo-responsiveness
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
, hPRL receptor
, secreted prolactin binding protein
, prolactin receptor long form
, equates to base 1078-1204 of D13154
, prolactin receptor b
, prolactin receptor
, prolactin receptor-like
, lactogen receptor
, prolactin receptor related sequence 1