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Circulating prolactin levels may not be higher in patients with Behcet's disease than in controls (meta-analysis).
Cin85 (zeige SH3KBP1 Proteine)-deficient mother mice had reduced pituitary hormone (zeige CGA Proteine) prolactin secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited.
PRL levels were lower in psychogenic non-epileptic seizure patients with a history of sexual abuse compared to healthy controls and healthy controls with a history of sexual abuse.
In newborns, serum PRL and hGH levels show a positive correlation that can be explained by common regulatory factors or a drift phenomenon. A higher gestational week is associated with a higher PRL/hGH ratio.
High normal circulating prolactin levels predict changes in haemodynamic indices and worsening endothelial function in healthy postmenopausal women. Particularly in young postmenopausal women, prolactin predicts accelerated arterial stiffening.
In conclusion, the present study provides evidence supporting a significantly positive association between plasma prolactin levels and the risk of breast cancer.
Our studies have demonstrated the essential role of endogenous PRL and CDK7 (zeige CDK7 Proteine) in the upregulation of PRLR (zeige PRLR Proteine) by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR (zeige PRLR Proteine) and its participation in breast cancer progression fueled by E2 and PRL via their cognate receptors.
GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin secretion.
This study revealed a significant association between the prolactin polymorphic variant rs1341239 and the development of hyperprolactinemia in patients with schizophrenia.
High serum prolactin and vasoinhibin levels predict and may impact retinopathy of prematurity progression
Study shows that prolactin was sufficient to suppress corticotrophin-releasing hormone (CRH (zeige CRH Proteine)) mRNA expression in the paraventricular nucleus, however it does not appear to be required for the ongoing regulation of the CRH (zeige CRH Proteine) neurones in lactation.
Mechanistically, RL negatively regulates Stat5 (zeige STAT5A Proteine) phosphorylation and Elf5 (zeige ELF5 Proteine) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 (zeige STAT5A Proteine) pathway.
Twenty-two separate mouse genes encode the placenta Prl-related hormones
Prolactin transport into mouse brain is independent of prolactin receptor (zeige PRLR Proteine).
Survivin directly participates in PRL-mediated beta cell proliferation via Akt (zeige AKT1 Proteine), STAT5 (zeige STAT5A Proteine)-PIM (zeige PIM1 Proteine) and ERK (zeige EPHB2 Proteine) signalling pathways during pregnancy
the mechanism by which kisspeptin is suppressed during lactation involves a number of factors, including chronically elevated levels of prolactin
Over 24 hours, males displayed no oscillation in PRL level; virgin and lactating females showed large pulses. Peaks reached 30-40 ng/mL in lactating mice and rarely exceeded 10 ng/mL in virgin mice. Pulses in lactating mice were associated with suckling.
Prolactin induces apoptosis of lactotropes
N-terminal PRL fragment increases during the involution period, has a proapoptotic effect on mammary epithelial cells, and is mainly generated by secreted cathepsin D (zeige CTSD Proteine) in the extracellular space of mammary glands.
PRL constrains tumor-promoting liver inflammation.
Taken together, these results support novel functions of prolactin as a modulator of the innate immune response that do not involve the classical prolactin pathway.
The presence and localization of prolactin receptor (zeige PRLR Proteine) are consistent with expression data reported for other species, and the presence of PIP (zeige PIP Proteine) and prolactin in seminal fluid is consistent with data generated in humans.
Functionally reciprocal mutations of the prolactin signaling pathway define hairy and slick cattle.
The single nucleotide polymorphism rs42646708 of cattle XKR4 was significantly associated with serum prolactin concentrations and explained 2.45% of the phenotypic variation.
Five mutations were identified in exonic region and eleven in associated intronic regions in PRL gene in 100 cattle from four Pakistani cattle breeds.
this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL gene transcription in dairy cow anterior pituitary cells
These data suggest that PRL protects brain endothelial cells against methamphetamine-induced toxicity
Bovine prolactin improved the expression of human transferrin (zeige Tf Proteine) through such a possible mechanism that bovine prolactin activated STAT5a (zeige STAT5A Proteine) transcription expression.
There was no significant difference between 1134 locus and milk performance traits of 5'-UTR of PRL gene
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
Prolactin and, to a lesser extent progesterone, which increase in early pregnancy, enhance basal and glucose-stimulated insulin (zeige INS Proteine) secretion in part by increasing glucokinase (zeige GCK Proteine) activity and amplifying cAMP levels.
iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction
despite a lack of clear relationship between PRL/C499T polymorphism in 5' UTR of the PRL gene and plasma prolactin cioncentration, gene polymorphism impact on reproductiove performance cannot be excluded
diameter. These results imply that the PRL gene polymorphism can be used as a molecular marker to improve fiber production without a negative effect on fiber diameter.
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein.
, prolactin, gene 3
, prolactin 2
, decidual prolactin
, prolactin family 1, subfamily a, member 1