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Authors demonstrate heterozygous novel or rare LIFR mutations in 3.3% of CAKUT patients, and provide evidence that Lifr deficiency and deactivating LIFR mutations cause highly similar anomalies of the urogenital tract in mice and humans.
uterine expression of the LIFR is essential for embryo implantation; this further define the components of the LIF (zeige LIF Proteine) signaling pathway necessary for effective implantation.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells.
both LIFR and gp130 protein expression were increased in the sciatic nerve and gastrocnemius muscle of diabetic mice.
Data confirmed that LIF (zeige LIF Proteine) and the LIFR were up-regulated in intra-implantation sites compared to inter-implantation sites on Day 5 of gestation.
Data demonstrate that T cells retain responsiveness to a LIF (zeige LIF Proteine)/Nanog (zeige NANOG Proteine) axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
Neuropoietin (zeige CTF2 Proteine) induced activation of STAT3 (zeige STAT3 Proteine) tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation.
Review. The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia (zeige BCL11A Proteine) cells are reviewed.
LIFR plays a role in modulating fetal response to high maternal glucocorticoids in late gestation, likely mediated through the glucocorticoid receptor (zeige NR3C1 Proteine), with implications for adult homeostasis as a direct tie between immune, neural & hormone function.
LIFR attenuates tumor metastasis by suppressing YAP (zeige YAP1 Proteine) expression, suggesting that LIFR may serve as a potential target for clear cell renal cell carcinoma (zeige MOK Proteine) treatment.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
Data show that lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR).
Significant reduction in LIFR expression and the reduced activation of subsequent signaling strongly suggest a working model of how the implantation markers, LIF (zeige LIF Proteine), may affect the endometrium of patients with adenomyosis.
study indicated impaired LIF (zeige LIF Proteine) expression levels only in women with unexplained infertility, while LIF-R expression was impaired in all sub-groups of infertile women.
Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.
Endometrial expression of LIF (zeige LIF Proteine) and LIFR is significantly reduced in the epithelial cells of infertile women.
LIFR inhibited the expression of beta-catenin (zeige CTNNB1 Proteine).
The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1 (zeige RUNX1 Proteine)
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5\;8)(p13\;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor
, CD118 antigen
, leukemia inhibitory factor receptor
, leukemia inhibitor factor receptor alpha-chain
, cytokine receptor-beta