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Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195
Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007
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Although rhLIF had no effect on proliferation, it inhibited apoptosis of degenerated nucleus pulposus cells in a concentrationdependent manner. LIF was upregulated during the process of intervertebral disc degeneration, and may promote the expression of extracellular matrix components.
Ruxolitinib-treated tumors in both the immunocompromised and immunocompetent animal models demonstrate decreased phospho-STAT3, indicating on-target activity. In conclusion, CA-MSC activate ovarian cancer cell STAT3 signaling via IL6 and LIF and increase tumor cell stemness.
In serum from human PDAC patients, authors found that LIF titers positively correlated with intratumoral nerve density.
miR-181c-3p and -5p promotes high-glucose-induced dysfunction in human umbilical vein endothelial cells by regulating leukemia inhibitory factor
The findings indicate that low LIF concentrations in serum and follicular fluid may contribute to disordered folliculogenesis in polycystic ovary syndrome.
This study uses LIF to activate the PI3K/ AKT signal and induce the anti-inflammatory effect during the neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells.
These findings implicate ZEB1 as a stem cell regulator in glioma via LIF repression which when deleted leads to increased stemness, tumorigenicity and shortened patient survival.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
The endometrial expression of LIF and CD34 in the pathogenesis of non-developing pregnancy can be used for evaluating the pregnancy prognosis in women of young and old reproductive age.
This report describes the involvement of proteins responsible for cell growth and progression and defines the LIF-mediated novel autocrine-paracrine signaling loop for cell growth arrest.
The expression of LIF was associated with tumor size and a poorer overall survival. Microarray and quantitative real-time polymerase chain reaction assessments suggest that LIF can facilitate tumor-promoting inflammation. Results indicate that LIF plays a role in maintaining cancer stem cells in chordomas.
study indicated impaired LIF expression levels only in women with unexplained infertility, while LIF-R expression was impaired in all sub-groups of infertile women.
findings illustrate that DeltaNp63alpha can inhibit the levels of LIF mRNA by direct transcription regulation and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS. An inverse interaction of LIF and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF in cervical cancers was related with poor patient survival.
ATF3 plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor.
Although further studies would be required to deconvolute the targets involved in LIF induction and to confirm activity of hits in more disease-relevant assays, our results have demonstrated the potential of the phenotypic approach to identify specific and chemically tractable small molecules that trigger the production of LIF in relevant cell lines
SNP 3951C/T of LIF may not be associated with in vitro fertilization and embryo transfer outcome in Iranian population.
In summary, this study has shown that LIF is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3/SOCS3 signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Cytokines of the LIF/CNTF family and metabolism
These results demonstrate the involvement of PIM kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Data suggest a 216-nucleotide proximal cis-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1, 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 = poly(rC) binding protein 1]
An existing single Muller cell microarray dataset was used to determine which processes are upregulated in Muller cells that express LIF, by correlating LIF expression to the expression of other genes using a robust correlation method. Some enriched processes include divalent inorganic cation homeostasis, negative regulation of stem cell proliferation, and gamma-glutamyl transferase activity.
The amplitude of inward currents in Muller cells from the postischemic retina was reduced to 51% in wild type and to 70% in LIF(-/-) mice. This demonstrates that decrease of inward currents takes place in reactive Muller cells even in the absence of LIF.
Inhibition of Lif protein in the hypothalamus transforms obesity-resistant mice into obesity-prone mice.
mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 and MEK/ERK signaling in naive embryonic stem cell pluripotency, is reported.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF-induced [Ca(2+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF signaling in the heart.
These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF/STAT3 signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3, PI3 kinases, or cAMP-protein kinase A pathways, are reported.
Either LIF or EGF is needed during development of pre-implantation embryo.
Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy.
Despite common signal transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.
Mechanistically, LIF activates STAT, which binds to a Stat consensus sequence in the Six2 proximal promoter and sustains SIX2 levels.
These findings suggest that maternal IL-6 interferes the maternal-fetal LIF signal relay by inducing SOCS3 in the placenta and leads to decreased neurogenesis.
Studied the expression of heme oxygenase-1 (HO-1) and leukemia inhibitory factor (LIF) in maternal plasma and placental tissue in intrauterine infection-induced preterm birth.
LIF gene breakage was captured at the 18th hour after carbon disulfide exposure by Comet-FISH and the protein and mRNA of LIF in uterine tissue were down-regulated after carbon disulfide exposure through the peri-implantation period
prenatal immunological stress delays the GnRH neuron migration in the nasal compartment of mouse fetuses, which may be mediated by the regulation of IL-6, MCP-1 and LIF secretion in the maternal-fetal system.
LIF has a role in primitive endoderm expansion during pre-implantation development
Study shows that LIF-treated postmitotic oligodendrocytes secrete a number of neuropeptides at the mRNA and peptide level, and confirm LIF-induced galanin synthesis and secretion in primary rat oligodendrocytes but not in astrocytes
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.
LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
The results indicated that the B allele at SNP locus LIF1 and the A allele at SNP locus LIF2 seem to have advantageous effects on litter size.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor are produced in the endometrium and may play different roles in early and mid-pregnancy
These findings expand our knowledge on the role of the LIF-LIFR signal pathway in early rabbit embryogenesis and rabbit embryonic stem cell establishment.
Leukemia inhibitory factor (LIF) can effectively accelerate the corneal nerve regeneration of rabbit eyes after LASIK surgery and decrease the occurrence of dry eye symptoms.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, differentiation-stimulating factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, d factor
, leukemia inhibitory factor (cholinergic differentiation factor)
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, Leukemia Inhibitory Factor (LIF)