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Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195
Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007
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This study uses LIF to activate the PI3K (zeige PIK3CA Proteine)/ AKT (zeige AKT1 Proteine) signal and induce the anti-inflammatory effect during the neuron differentiation from human induced pluripotent stem cell-derived neural precursor cells.
These findings implicate ZEB1 as a stem cell regulator in glioma via LIF repression which when deleted leads to increased stemness, tumorigenicity and shortened patient survival.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
The endometrial expression of LIF and CD34 (zeige CD34 Proteine) in the pathogenesis of non-developing pregnancy can be used for evaluating the pregnancy prognosis in women of young and old reproductive age.
This report describes the involvement of proteins responsible for cell growth and progression and defines the LIF-mediated novel autocrine-paracrine signaling loop for cell growth arrest.
The expression of LIF was associated with tumor size and a poorer overall survival. Microarray and quantitative real-time polymerase chain reaction assessments suggest that LIF can facilitate tumor-promoting inflammation. Results indicate that LIF plays a role in maintaining cancer stem cells in chordomas.
study indicated impaired LIF expression levels only in women with unexplained infertility, while LIF-R (zeige LIFR Proteine) expression was impaired in all sub-groups of infertile women.
findings illustrate that DeltaNp63alpha can inhibit the levels of LIF mRNA by direct transcription regulation and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS. An inverse interaction of LIF and DeltaNp63alpha expression was as well validated in clinical samples of cervical cancer, and high level of LIF in cervical cancers was related with poor patient survival.
ATF3 (zeige ATF3 Proteine) plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor.
Although further studies would be required to deconvolute the targets involved in LIF induction and to confirm activity of hits in more disease-relevant assays, our results have demonstrated the potential of the phenotypic approach to identify specific and chemically tractable small molecules that trigger the production of LIF in relevant cell lines
Inhibition of Lif protein in the hypothalamus transforms obesity-resistant mice into obesity-prone mice.
mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 (zeige STAT3 Proteine) and MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling in naive embryonic stem cell pluripotency, is reported.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 (zeige SOCS2 Proteine) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (zeige CA2 Proteine)+)] raise, indicating that endogenous levels of SOCS2 (zeige SOCS2 Proteine) are crucial for full activation of LIF signaling in the heart.
These results establish that Bcl3 (zeige BCL3 Proteine) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (zeige BCL3 Proteine) as a downstream molecule of LIF/STAT3 (zeige STAT3 Proteine) signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3 (zeige STAT3 Proteine), PI3 (zeige PI3 Proteine) kinases, or cAMP-protein kinase A pathways, are reported.
Either LIF or EGF (zeige EGF Proteine) is needed during development of pre-implantation embryo.
Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy.
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (zeige STAT3 Proteine) markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.
LIF and IL-6 (zeige IL6 Proteine) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (zeige RBP4 Proteine)) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (zeige CSF2 Proteine) are produced in the endometrium and may play different roles in early and mid-pregnancy
Leukemia inhibitory factor (LIF) can effectively accelerate the corneal nerve regeneration of rabbit eyes after LASIK surgery and decrease the occurrence of dry eye symptoms.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, differentiation-stimulating factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, d factor
, leukemia inhibitory factor (cholinergic differentiation factor)
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, Leukemia Inhibitory Factor (LIF)