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Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917
Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011
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Sheep (Ovine) Leptin Protein expressed in - ABIN623942
Szczesna, Zieba, Klocek-Gorka, Misztal, Stepien: Seasonal effects of central leptin infusion and prolactin treatment on pituitary SOCS-3 gene expression in ewes. in The Journal of endocrinology 2010
Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914
Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006
the study reports a novel mechanistic pathway of leptin-mediated renal inflammation that is dependent on NOX-2 (zeige CYBB Proteine)-miR21 axis in ectopic manifestations underlying non-alcoholic fatty liver disease-induced co-morbidities
These results demonstrated a novel molecular mechanism by which leptin sustained oligodendrocyte precursor cell proliferation and remyelination in a pathological central nervous system.
These data demonstrate that FAAH (zeige FAAH Proteine) activity is required for leptin's hypophagic effects
These data uncouple the mechanisms conferring qualitative and quantitative expression of the leptin gene and further suggest that factor(s) that bind to LepRE1 (zeige LEPRE1 Proteine) quantitatively control leptin expression and might be components of a lipid-sensing system in adipocytes.
These results indicate that leptin plays a role in nociception induced by acute inflammation
results suggest that STAT (zeige STAT1 Proteine) transcriptional activity is downregulated by high levels of leptin, leading to reduced cAMP-dependent steroidogenic genes (Star and Cyp11a1 (zeige CYP11A1 Proteine)) expressions in MA-10 Leydig cells.
Data suggest that lnc-leptin is among the most prominent lncRNAs expressed in adipocytes; lnc-leptin expression from an enhancer region upstream of leptin is sensitive to insulin (zeige INS Proteine) and correlates to leptin expression across diverse pathophysiological conditions; induction of lnc-leptin is essential for adipogenesis; its presence is required for maintenance of leptin expression in adipocytes. (lnc = long non-coding RNA)
Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin-receptor (zeige LEPR Proteine) (Lep/Lepr (zeige LEPR Proteine)) signaling in hypothalamic neurons regulate energy metabolism; Lep/Lepr (zeige LEPR Proteine) signaling appears to up-regulate expression of Atf3 (activating transcription factor-3 (zeige ATF3 Proteine)) in hypothalamic neurons.
Study shows that compared to the other mouse lines, db/db (zeige LEPR Proteine) mice with dysfunctional leptin receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin signaling.
The studies established a potential link between leptin and adipocyte insulin responsiveness in an NOS2 dependent manner.
Leptin concentrations are higher in the obese group irrespective of their glucose tolerance
Leptin-to-adiponectin ratio and IL-6 (zeige IL6 Proteine) were elevated in men with prostate cancer. Leptin, chemerin (zeige RARRES2 Proteine) and IL-6 (zeige IL6 Proteine) were associated with Gleason score. The relationships between leptin, chemerin (zeige RARRES2 Proteine) and IL-6 (zeige IL6 Proteine) were dependent on each other.
Results provide new evidences for a modulatory effect of leptin in regulation of ovarian cancer cell invasion by stimulating MMP7 (zeige MMP7 Proteine) expression via ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine) pathways.
this study shows that leptin regulates the pro-inflammatory response in human epidermal keratinocytes
AMH (zeige AMH Proteine), IGF1 (zeige IGF1 Proteine) and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis or fallopian tube damage, though they are biomarkers for anovulatory fertility disorders.
Our data provide evidence that leptin-mediated OPN (zeige SPP1 Proteine) upregulation promote TH2 inflammation in AR and this process is achieved through the alpha4 integrin and PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathways.
By functional analysis based on a set of 1129 proteins from 494 obese subjects study identified and validated FAM46A as a trans regulator for leptin.
Cord blood klotho (zeige KL Proteine) levels were inversely correlated with leptin and insulin (zeige INS Proteine) levels at birth
Estradiol and physical activity were stronger predictors of leptin at menses, while sexual activity was a stronger predictor of leptin at ovulation. These findings suggest that predictors of serum leptin, and possibly energy storage and expenditure, vary across the menstrual cycle.
leptin, leptin receptor (zeige LEPR Proteine) and apelin receptor (zeige APLNR Proteine) genes are associated with susceptibility to coronary artery disease and hypertension
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (zeige LEPR Proteine) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (zeige LEPR Proteine) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
Consistent with this, leptin enhanced GnRH (zeige GNRH1 Proteine)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (zeige CA2 Proteine)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (zeige NPY Proteine) and insulin (zeige INS Proteine) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (zeige NPY Proteine)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (zeige CSF2 Proteine) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (zeige IGF1 Proteine) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (zeige GHRL Proteine).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL (zeige GHRL Proteine), LEP, ADIP (zeige SSX2IP Proteine), INS (zeige INS Proteine) and CORT (zeige CORT Proteine) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin (zeige RETN Proteine) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of