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Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917
Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011
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Sheep (Ovine) Leptin Protein expressed in - ABIN623942
Szczesna, Zieba, Klocek-Gorka, Misztal, Stepien: Seasonal effects of central leptin infusion and prolactin treatment on pituitary SOCS-3 gene expression in ewes. in The Journal of endocrinology 2010
Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914
Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006
Taken together, these results suggest that leptin, in concert with other stimuli in the micro milieu, may contribute to the development of psoriasis.
Thus, Mc4r (zeige MC4R Proteine) in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia. Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health.
t the cellular level, leptin promoted effector T-cell responses and facilitated the presentation of self-antigens to T cells, whereas it inhibited the activity of regulatory CD4 (zeige CD4 Proteine) T cells. The understanding of the role of leptin in modulating autoimmune responses in SLE can open possibilities of leptin-targeted therapeutic intervention in the disease.
plasma adiponectin and leptin were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism
in congenitally leptin deficient animals, leptin is not required for compensatory reduction in energy expenditure accompanying weight loss, but suggest that the hyperphagia of the weight-reduced state is leptin-dependent.
Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD.
Data suggest that Htr2c (zeige HTR2C Proteine) and leptin in hypothalamic nuclei may be involved in the effects of corticosterone on food intake/appetite regulation. (Htr2c (zeige HTR2C Proteine) = 5-hydroxytryptamine type 2C receptor)
Further experiments indicated that miR (zeige MLXIP Proteine)-122 inhibited leptin-induced liver fibrosis in leptin-deficient mouse model.
Endoplasmic reticulum stress-induced CHOP (zeige DDIT3 Proteine) activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin and IGF1 (zeige IGF1 Proteine).
neuronal Rap1 (zeige TERF2IP Proteine) critically regulates leptin sensitivity
Serum leptin may be a biomarker for adiposity in infancy in preterm very-low-birth-weight infants and could predict subsequent risk for abnormalities of metabolism, obesity, and cardiovascular risk.
Data suggest that, in type 1 diabetes, elevated leptin is related to decreased cardiopulmonary fitness/exercise tolerance in adolescents/young adults; this relationship is independent of insulin (zeige INS Proteine) resistance and adiposity/body mass index. This study was conducted in Colorado.
Leptin treatment increased cell cycle progression and proliferation, and the expression of Notch (zeige NOTCH1 Proteine) receptors, ligands and targeted molecules in pancreatic tumor cells.
placental leptin and LEPR protein expression may influence placental growth and thus, birth weight.
Depression was associated with a decrease and increase in leptin respectively in normal-overweight and obese men and women diabetes patients.
The genotype-risk associations were examined between LEP (rs2167270) and obesity-related phenotypes and other comorbidities in Sucre, Venezuela. The relation to BMI for the G/G phenotype was 25.04 +/- 4.20 kg/m2, for A/A/ it was 25.87 +/- 4.08 kg/m2, and for G/A it was 27.02 +/- 4.08 kg/m2.
these findings indicate that leptin may promote tumor growth and metastasis by stimulating IL-8 (zeige IL8 Proteine) production in tumor-associated macrophage
Serum leptin levels were decreased following individualized resistance exercise in lean women with fibromyalgia.
Review/Meta-analysis: genetic polymorphisms in leptin, adiponectin and their receptors affect the development and progression of prostate cancer.
In prevalent kidney transplant recipients, lower serum leptin was an independent predictor of death.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (zeige LEPR Proteine) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (zeige LEPR Proteine) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
Consistent with this, leptin enhanced GnRH (zeige GNRH1 Proteine)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (zeige CA2 Proteine)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (zeige NPY Proteine) and insulin (zeige INS Proteine) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (zeige NPY Proteine)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (zeige CSF2 Proteine) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (zeige IGF1 Proteine) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (zeige GHRL Proteine).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL (zeige GHRL Proteine), LEP, ADIP (zeige SSX2IP Proteine), INS (zeige INS Proteine) and CORT (zeige CORT Proteine) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin (zeige RETN Proteine) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of