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Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917
Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011
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Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914
Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006
Sheep (Ovine) Leptin Protein expressed in - ABIN623942
Szczesna, Zieba, Klocek-Gorka, Misztal, Stepien: Seasonal effects of central leptin infusion and prolactin treatment on pituitary SOCS-3 gene expression in ewes. in The Journal of endocrinology 2010
Further experiments indicated that miR (zeige MLXIP Proteine)-122 inhibited leptin-induced liver fibrosis in leptin-deficient mouse model.
Endoplasmic reticulum stress-induced CHOP (zeige DDIT3 Proteine) activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin and IGF1 (zeige IGF1 Proteine).
neuronal Rap1 (zeige TERF2IP Proteine) critically regulates leptin sensitivity
Upregulation of leptin levels in both the vessel wall and the circulation after vessel injury promoted the migration of Sca-1(+) progenitor cells via leptin receptor (zeige LEPR Proteine)-dependent signal transducer and activator of transcription 3 (zeige STAT3 Proteine)- Rac1/Cdc42 (zeige CDC42 Proteine)-ERK (zeige EPHB2 Proteine) (extracellular signal-regulated kinase)-FAK (zeige PTK2 Proteine) pathways, which enhanced neointimal formation.
Depletion of CLPABP disturbed the normal subcellular localization of HuR (zeige ELAVL1 Proteine) to stress granules, and overexpression of CLPABP induced instability of leptin mRNA by inhibiting HuR (zeige ELAVL1 Proteine) function.
These results confirm and extend the previous evidence that LEP has a general and important role in the response of mammalian cells to irradiation.
leptin is involved in the proliferation and activation of microglia, which in turn enhances the development of neuropathic pain after avulsion of the cervical roots.
Suggest that intact endothelial leptin signaling limits neointima formation and that obesity represents a state of endothelial leptin resistance.
these studies demonstrate marked differences in the acute insulin (zeige INS Proteine)-independent effects by which leptin reverses fasting hyperglycemia and ketoacidosis in a rodent model of DKA versus the chronic pleotropic effects by which leptin reverses hyperglycemia in a non-DKA rodent model of T1D.
High fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most (but not all) brain regions, while other brain regions display hypersensitivity to leptin following weight loss
Elevated level of soluble tumor necrosis factor (zeige TNF Proteine) receptors 1 and lower level of leptin are associated with higher developmental outcomes in infants between the ages of 6 and 24 months.
In the infertile me, serum leptin level was significantly and inversely correlated with BMI.
we speculate that up-regulation of leptin and ARMS2 (zeige ARMS2 Proteine) forms part of an important survival mechanism to compensate for placental growth discordance in monochorionic diamniotic twin pregnancies
The results indicated that globular adiponectin inhibited the prooncogenic effects of leptin via AdipoR2 (zeige ADIPOR2 Proteine)-mediated suppression of UHRF1 (zeige UHRF1 Proteine)
OB-Rb (zeige LEPR Proteine), RhoA (zeige RHOA Proteine)/ROCK, PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine), JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) pathways and NF-kB activation are involved in leptin-induced upA (zeige PRAP1 Proteine) expression.
Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations.
Higher leptin concentration was associated with increased risk of impaired physical function in older adults.
disturbance of reciprocal relationships between adipsin (zeige CFD Proteine) and leptin in obesity is associated with the development of insulin (zeige INS Proteine) resistance
The leptin SNP rs7799039 (G2548A) was associated to high sensitivity-C-reactive protein (zeige CRP Proteine) levels at both ages.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (zeige LEPR Proteine) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (zeige LEPR Proteine) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
Consistent with this, leptin enhanced GnRH (zeige GNRH1 Proteine)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (zeige CA2 Proteine)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (zeige NPY Proteine) and insulin (zeige INS Proteine) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (zeige NPY Proteine)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (zeige CSF2 Proteine) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (zeige IGF1 Proteine) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (zeige GHRL Proteine).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 (zeige CD36 Proteine) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL (zeige GHRL Proteine), LEP, ADIP (zeige SSX2IP Proteine), INS (zeige INS Proteine) and CORT (zeige CORT Proteine) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin (zeige RETN Proteine) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of