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identification of activating somatic mutations in JAK2 (zeige JAK2 Proteine) and germline mutations in JAK3 with clinical implications
we report the results of a screening for mutations in SETBP1 (zeige SETBP1 Proteine) and JAK3 of a cohort of seventy Italian patients with juvenile myelomonocytic leukemia, identifying 11.4% of them harboring secondary mutations in these two genes and discovering two new mutations in the SKI (zeige SKI Proteine) domain of SETBP1 (zeige SETBP1 Proteine)
Jak3-mediated phosphorylation of beta-catenin (zeige CTNNB1 Proteine) suppressed EGF (zeige EGF Proteine)-mediated epithelial-mesenchymal transition and facilitated epithelial barrier functions by AJ localization of phosphorylated beta-catenin (zeige CTNNB1 Proteine) through its interactions with alpha-catenin (zeige CTNNA1 Proteine).
frequency of JAK3 mutations in the JH2 domain was relatively low in extranodal natural killer/T-cell lymphoma, nasal type (NTCL) in contrast to a previous report; study identified novel JAK3H583Y- and JAK3G589D-activating mutations that were oncogenic and sensitive to a JAK3 inhibitor
In natural killer/T-cell lymphoma (NKTL) as a disease model, phosphorylation of EZH2 (zeige EZH2 Proteine) by JAK3 promotes the dissociation of the PRC2 complex leading to decreased global histone H3 (zeige HIST3H3 Proteine) lysine 27 methylation levels.
a causal relationship between MLH1 (zeige MLH1 Proteine)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
JAK3 mediates smooth muscle cell proliferation and survival during injury-induced vascular remodeling.
Data indicate that phosphorylation of Janus kinase 3 (JAK3) and STAT3 (zeige STAT3 Proteine) transcription factor (STAT3 (zeige STAT3 Proteine)) was inhibited by latent membrane protein 1 (LMP1 (zeige PDLIM7 Proteine))-IgG.
analysis of JAK3 kinetic mechanism and inhibition by tofacitinib
patient had a homozygote of the JAK3 mutation, and her parents were heterozygous carriers.
Blockade of JAK1 (zeige JAK1 Proteine)-JAK3 accelerated, and selective inactivation of STAT3 (zeige STAT3 Proteine) decelerated differentiation of progenitor cells.
Study investigated the effect of Jak3 signaling on differentiation from nestin (zeige NES Proteine) progenitor cells using E13.5 spinal progenitor cell cultures. Results indicated that neuronal and microglial cell differentiation was regulated primarily by Jak3 signaling and the developing neurons and neurite outgrowth might also be regulated by Jak3-dependent microglial activity.
Small-scale in vivo screening identified several genes, including Cd109 (zeige CD109 Proteine), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (zeige STAT3 Proteine) as a critical, pharmacologically targetable effector of CD109 (zeige CD109 Proteine)-driven lung cancer metastasis
JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and JAK3 are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.
JAK3 up-regulates SGLT1 (zeige SLC5A1 Proteine) activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.
This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 kinase activity in IL-2 (zeige IL2 Proteine)-driven T cell proliferation.
Experiments implicate JAK1 (zeige JAK1 Proteine)/3 signaling in cancer- and myocardial infarction-mediated diaphragm weakness in mice.
Foxp3 (zeige FOXP3 Proteine) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (zeige STAT1 Proteine) pathway
Data show that IL-4 (zeige IL4 Proteine) induces upregulation of the junction protein claudin-5 (zeige CLDN5 Proteine) in endothelial cells (ECs) through activation of Jak/STAT6 (zeige STAT6 Proteine) and phosphorylation and translocation of FoxO1 (zeige FOXO1 Proteine) from the nucleus to the cytoplasm.
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
, leukocyte Janus kinase
, tyrosine-protein kinase JAK3
, Janus kinase 3 protein-tyrosine kinase
, Janus kinase 3, protein-tyrosine kinase
, Janus tyrosine kinase