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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Proteine) signal.
Considering JAK2(V617F) -positive disease, a higher (>50%) JAK2(V617F) burden and histological classification are independent prognostic risk factors for disease progression.
Taken together, we found that silibinin inhibits the Jak2/STAT3 (zeige STAT3 Proteine)/MMP2 (zeige MMP2 Proteine) signaling pathway, and inhibits the proliferation, migration, and invasion of triple-negative breast cancer cells.
in molecularly annotated ET patients at diagnosis, JAK2-V617F patients have more circulating microparticles and higher MP-associated procoagulant activities than CALR (zeige CALR Proteine)-mutated and TN ET patients.
We report a novel somatic mutation in JAK2 exon 14, and show that sequencing of exon 14 can identify a small proportion of PV-associated mutations that would be missed by most diagnostic laboratories.
we have identified JAK2V617F mutations in JAK2V617F BM E-CFC from JAK2V617F MPN-neg patients with BCS. We have also demonstrated the absence of recurrent myeloid-associated mutations and a low JAK2V617F VAF in the granulocytes of these patients.
The co-occurrence of JAK2 V617F and BCR (zeige BCR Proteine)-ABL1 (zeige ABL1 Proteine) clones in the same patient is a rare event.
JAK2 and CALR (zeige CALR Proteine) mutations have roles in patients with essential thrombocythemia
onstitutive Gab1-dependent signalling in Jak2-V617F-expressing cells does not occur due to the constitutive association of Gab1 with PIP3 at the plasma membrane.
The results suggested that HGF (zeige HGF Proteine) may inhibit TEMT (zeige INMT Proteine) by inhibiting AngII through the JAK2/STAT3 (zeige STAT3 Proteine) signaling pathway in HK2 (zeige HK2 Proteine) cells and HGF (zeige HGF Proteine) may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT (zeige INMT Proteine) by HGF (zeige HGF Proteine), which requires further investigation
Clinical features of JAK2V617F- or CALR (zeige CALR Proteine)-mutated essential thrombocythemia and primary myelofibrosis.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (zeige STAT3 Proteine) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (zeige STAT3 Proteine) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (zeige STAT3 Proteine) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (zeige CISH Proteine) interacted with phosphorylated EpoR (zeige EPOR Proteine) at Y401, which was critical for the activation of STAT5 (zeige STAT5A Proteine) and ERK (zeige EPHB2 Proteine).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Proteine)(mut (zeige MUT Proteine)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Proteine) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Proteine) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Proteine) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Proteine)
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine)-AKT (zeige AKT1 Proteine) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Proteine) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Proteine) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase