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Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Proteine) signal.
Our study shows that JAK2V617F leads to abnormal expression of numerous proteins at the membrane of circulating PV red blood cells, with overexpression of CALR (zeige CALR Proteine) and persistence of CANX (zeige CANX Proteine)
In 94.9% of PV, 85.5% ET and 85.2% PMF (zeige PRB1 Proteine), authors found mutations in JAK2, MPL (zeige MPL Proteine) or CALR (zeige CALR Proteine). 74.9% carried JAK2V617F, 12.3% CALR (zeige CALR Proteine) mutations, 2.1% MPL (zeige MPL Proteine) mutations and 10.7% were triple negative.
tyrphostin B42 (zeige PNRC1 Proteine) induced the apoptosis of pancreatic cancer cells (PCCs) by regulating the expression of mitochondrialrelated genes. Therefore, these findings demonstrated that tyrphostin B42 (zeige PNRC1 Proteine) attenuated trichostatin A resistance in PCCs by antagonizing the IL6 (zeige IL6 Proteine)/JAK2/STAT3 (zeige STAT3 Proteine) signaling
MiR (zeige MLXIP Proteine)-375 inhibits fetal ASM (zeige SMPD1 Proteine) cell proliferation and migration by targeting JAK2/STAT3 (zeige STAT3 Proteine) signaling.
Overexpression of ALK4 (zeige ACVR1B Proteine) suppressed glioma cell proliferation, migration and invasion through the inactivation of JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway.
We describe a subset of non-small-cell lung cancer patients who had JAK2 amplifications resulting in high expression of PD-L1 (zeige CD274 Proteine)
High JAK2 expression is associated with hepatocellular carcinoma.
JAK2 haplotype 46/1 and JAK2 V617F allele burden in MPN (zeige PRSS27 Proteine)
Low JAK2 expression is associated with gastric cancer.
The authors discovered tyrosine 78 of Atoh1 (zeige ATOH1 Proteine) is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog (zeige SHH Proteine)-type medulloblastoma.
While expression of mutant Jak2 was necessary for leukemia induction, neither its continued expression nor enzymatic activity was required to maintain leukemia survival and rapid proliferation
High JAK2 expression is associated with graft-versus-host disease.
Results demonstrate that JAK2 deficiency delays tumor formation in GH-transgenic mice, which is linked to insignificant oncogenic STAT3 (zeige STAT3 Proteine) signaling and reduced reactive oxygen species-induced oxidative damage.
Reg3g (zeige REG3g Proteine) acts as an immunosuppressive promoter by activating the JAK2/STAT3 (zeige STAT3 Proteine) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
High JAK2 expression is associated with skeletal muscle wasting in cancer cachexia.
Data (including data from studies in knockout mice) suggest that various tissues utilize Jak2 signaling to regulate insulin (zeige INS Proteine), glucose, and lipid metabolism; adipocyte Jak2 appears to regulate hepatic insulin (zeige INS Proteine) resistance in mechanism independent of adiposity (obesity), liver lipid content (non-alcoholic fatty liver disease), and hepatic insulin (zeige INS Proteine) signaling.
Advanced glycation end products induce apoptosis and inflammation in mouse podocytes through CXCL9 (zeige CXCL9 Proteine)-mediated JAK2/STAT3 (zeige STAT3 Proteine) pathway activation.
Cilostazol protects MIR (zeige MLXIP Proteine) injury by activating a PPARgamma (zeige PPARG Proteine)/JAK2/STAT3 (zeige STAT3 Proteine) pathway.
These results suggest that JAK2 regulated the microfilaments aggregation during the mouse oocyte maturation.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (zeige STAT3 Proteine) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine)-AKT (zeige AKT1 Proteine) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Proteine) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Proteine) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase