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anti-Human JAK2 Antikörper:
anti-Mouse (Murine) JAK2 Antikörper:
anti-Rat (Rattus) JAK2 Antikörper:
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Human JAK2 Primary Antibody für IHC - ABIN966430
Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. in Molecular and cellular biology 2004
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN966429
Mol, de Rijke, Demacker, Stalenhoef: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. in Atherosclerosis 1997
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Human JAK2 Primary Antibody für IHC - ABIN966431
Feener, Rosario, Dunn, Stancheva, Myers: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. in Molecular and cellular biology 2004
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Human Polyclonal JAK2 Primary Antibody für FACS, IF - ABIN387982
Joos, Granzow, Holtgreve-Grez, Siebert, Harder, Martín-Subero, Wolf, Adamowicz, Barth, Lichter, Jauch: Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. in International journal of cancer. Journal international du cancer 2002
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN969223
Pezet, Buteau, Kelly, Edery: The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. in Molecular and cellular endocrinology 1997
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Human Polyclonal JAK2 Primary Antibody für IF (p), IHC (p) - ABIN740955
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Human Polyclonal JAK2 Primary Antibody für IF (p), IHC (p) - ABIN742853
Liao, Hu, Guo, Zhang, Xu, Jiang: Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway. in Molecular medicine reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Antikörper) signal.
Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta (zeige IL1B Antikörper) by inhibiting the aggregation of NALP1 (zeige NLRP1 Antikörper) inflammasome and the activation of the JAK2-STAT3 (zeige STAT3 Antikörper) cascade in astrocytes.
High level of phosphorylated JAK2, and STAT3 (zeige STAT3 Antikörper) are associated with systemic lupus erythematosus.
this study shows that Nrf2 (zeige GABPA Antikörper) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3 (zeige SOCS3 Antikörper)-dependent feedback inhibition on JAK2/STAT3 (zeige STAT3 Antikörper) cascade
bladder cancer cell may inhibit maturation and function of dendritic cells involving of Jak2/STAT3 (zeige STAT3 Antikörper) pathway, and there may be different mechanisms by which adriamycin-resistant BCC restrains DC function in antitumor immune response
Multivariate analysis adjusted for age, sex, follow-up period and hematological parameters confirmed that increased activated B cells were universally present in JAK2-mutated, CALR (zeige CALR Antikörper)-mutated and triple-negative ET patients when compared to healthy adults.
In multivariable analysis, younger age, platelet count, hemoglobin (zeige HBB Antikörper) level and JAK2 V617F mutation independently predicted the development of acquired von Willebrand syndrome (AVWS) among essential thrombocythemia (ET)patients; whereas only platelet count predicted its development among polycythemia vera (zeige IGF2BP3 Antikörper) (PV) patients. Among ET patients, JAK2 V617F was a main driver for the development of AVWS.
CXCR4 (zeige CXCR4 Antikörper) induced VEGF (zeige VEGFA Antikörper) production and JAK2/STAT3 (zeige STAT3 Antikörper) activation and enhanced STAT3 (zeige STAT3 Antikörper) binding to VEGF (zeige VEGFA Antikörper) promoter in gastric cancer cells.
these results reveal proteome alterations in MPN (zeige PRSS27 Antikörper) granulocytes depending on the phenotype and genotype of patients, highlighting new oncogenic mechanisms associated with JAK2 mutations and overexpression of calreticulin (zeige CALR Antikörper)
JAK2 mutation is associated with Essential thrombocythemia.
Considering JAK2(V617F) -positive disease, a higher (>50%) JAK2(V617F) burden and histological classification are independent prognostic risk factors for disease progression.
These results suggest that JAK2 regulated the microfilaments aggregation during the mouse oocyte maturation.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (zeige STAT3 Antikörper) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (zeige STAT3 Antikörper) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (zeige STAT3 Antikörper) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (zeige CISH Antikörper) interacted with phosphorylated EpoR (zeige EPOR Antikörper) at Y401, which was critical for the activation of STAT5 (zeige STAT5A Antikörper) and ERK (zeige EPHB2 Antikörper).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Antikörper)(mut (zeige MUT Antikörper)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Antikörper) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Antikörper) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper)-AKT (zeige AKT1 Antikörper) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Antikörper) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Antikörper) and mTOR (zeige FRAP1 Antikörper) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Antikörper) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase