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anti-Human JAK2 Antikörper:
anti-Mouse (Murine) JAK2 Antikörper:
anti-Rat (Rattus) JAK2 Antikörper:
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Human JAK2 Primary Antibody für IHC - ABIN966430
Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. in Molecular and cellular biology 2004
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN966429
Mol, de Rijke, Demacker, Stalenhoef: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. in Atherosclerosis 1997
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Human JAK2 Primary Antibody für IHC - ABIN966431
Feener, Rosario, Dunn, Stancheva, Myers: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. in Molecular and cellular biology 2004
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Human Polyclonal JAK2 Primary Antibody für FACS, IF - ABIN387982
Joos, Granzow, Holtgreve-Grez, Siebert, Harder, Martín-Subero, Wolf, Adamowicz, Barth, Lichter, Jauch: Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. in International journal of cancer. Journal international du cancer 2002
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN969223
Pezet, Buteau, Kelly, Edery: The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. in Molecular and cellular endocrinology 1997
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Human Polyclonal JAK2 Primary Antibody für IF (p), IHC (p) - ABIN740955
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Human Polyclonal JAK2 Primary Antibody für IF (p), IHC (p) - ABIN742853
Liao, Hu, Guo, Zhang, Xu, Jiang: Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway. in Molecular medicine reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Antikörper) signal.
Taken together, we found that silibinin inhibits the Jak2/STAT3 (zeige STAT3 Antikörper)/MMP2 (zeige MMP2 Antikörper) signaling pathway, and inhibits the proliferation, migration, and invasion of triple-negative breast cancer cells.
in molecularly annotated ET patients at diagnosis, JAK2-V617F patients have more circulating microparticles and higher MP-associated procoagulant activities than CALR (zeige CALR Antikörper)-mutated and TN ET patients.
We report a novel somatic mutation in JAK2 exon 14, and show that sequencing of exon 14 can identify a small proportion of PV-associated mutations that would be missed by most diagnostic laboratories.
we have identified JAK2V617F mutations in JAK2V617F BM E-CFC (zeige PTPN11 Antikörper) from JAK2V617F MPN (zeige PRSS27 Antikörper)-neg (zeige TMEM131 Antikörper) patients with BCS (zeige BCS1L Antikörper). We have also demonstrated the absence of recurrent myeloid-associated mutations and a low JAK2V617F VAF in the granulocytes of these patients.
The co-occurrence of JAK2 V617F and BCR (zeige BCR Antikörper)-ABL1 (zeige ABL1 Antikörper) clones in the same patient is a rare event.
JAK2 and CALR (zeige CALR Antikörper) mutations have roles in patients with essential thrombocythemia
onstitutive Gab1-dependent signalling in Jak2-V617F-expressing cells does not occur due to the constitutive association of Gab1 with PIP3 at the plasma membrane.
The results suggested that HGF (zeige HGF Antikörper) may inhibit TEMT (zeige INMT Antikörper) by inhibiting AngII through the JAK2/STAT3 (zeige STAT3 Antikörper) signaling pathway in HK2 (zeige HK2 Antikörper) cells and HGF (zeige HGF Antikörper) may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT (zeige INMT Antikörper) by HGF (zeige HGF Antikörper), which requires further investigation
Clinical features of JAK2V617F- or CALR (zeige CALR Antikörper)-mutated essential thrombocythemia and primary myelofibrosis.
NGS may be useful to identify a minority of Polycythemia vera (zeige IGF2BP3 Antikörper) and essential thrombocythemia patients with high genetic instability and increased risk of acute myeloid leukemia (zeige BCL11A Antikörper) transformation.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 (zeige STAT3 Antikörper) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (zeige STAT3 Antikörper) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (zeige STAT3 Antikörper) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (zeige CISH Antikörper) interacted with phosphorylated EpoR (zeige EPOR Antikörper) at Y401, which was critical for the activation of STAT5 (zeige STAT5A Antikörper) and ERK (zeige EPHB2 Antikörper).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Antikörper)(mut (zeige MUT Antikörper)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Antikörper) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Antikörper) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Antikörper) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Antikörper)
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper)-AKT (zeige AKT1 Antikörper) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Antikörper) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Antikörper) and mTOR (zeige FRAP1 Antikörper) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Antikörper) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase