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anti-Human JAK1 Antikörper:
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Chicken Monoclonal JAK1 Primary Antibody für IF, IP - ABIN967842
Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001
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Chicken Monoclonal JAK1 Primary Antibody für IF, IP - ABIN967841
Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. in The Journal of experimental medicine 2001
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Human JAK1 Primary Antibody für IHC - ABIN966427
Wang, Griffin, Small, Thompson: Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide. in Archives of biochemistry and biophysics 2003
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Human Polyclonal JAK1 Primary Antibody für IHC - ABIN966428
Zheng, Hu, Quinn, Wang: Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. in Molecular & cellular proteomics : MCP 2005
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Human Polyclonal JAK1 Primary Antibody für IHC, WB - ABIN362146
Cha, Moon, Lee, Ahn, Lee, Lee, Fornace, Kim, Cha, Park: Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling. in Stem cells (Dayton, Ohio) 2010
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Human Polyclonal JAK1 Primary Antibody für IHC, WB - ABIN362702
Liu, Huang, Zeng, Chen, Huang, Guo, Liu, Xu, Mo, Li: Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. in Journal of cancer research and clinical oncology 2011
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JAK1 mutations are highly frequent in microsatellite unstable endometrial cancer, not associated with survival, but are associated with impaired upregulation of LMP7 (zeige PSMB8 Antikörper) and HLA class I (zeige MICA Antikörper) and may therefore facilitate immune escape
We found that a significant higher gastric cancer risk was associated with IL-6 (zeige IL6 Antikörper) rs2069837G variant genotypes and JAK1 rs2230587A variant genotypes
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (zeige IFNA Antikörper) on hepatocellular carcinoma cell proliferation through activation of the JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling pathway by inhibiting SOCS3 (zeige SOCS3 Antikörper) expression.
JAK1 frameshifts are loss of function alterations that represent a potential pan (zeige SUPT6H Antikörper)-cancer adaptation to immune responses against tumors with microsatellite instability
Study provides evidence that JAK1/2 loss-of-function mutations are a genetic mechanism of lack of reactive PD-L1 (zeige CD274 Antikörper) expression and response to interferon gamma (zeige IFNG Antikörper), leading to primary resistance to PD-1 (zeige PDCD1 Antikörper) blockade therapy.
This study demonstrates that the nuclear import of JAK1 is essential for the optimal fitness of ABC (zeige ABCB6 Antikörper) DLBCL cells.
JAK1 rs11576173 and rs1497056 genotypes were significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Multiple myeloma cells over express JAK1/2 and suggest combined chemotherapy with ruxolitinib, bortezomib and lenalidomide to inhibit JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) pathway.
Mechanistic investigations reveal that AJUBA (zeige AJUBA Antikörper) specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNgamma recepter, resulting in an inhibition of STAT1 (zeige STAT1 Antikörper) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (zeige AJUBA Antikörper) in CRC (zeige CALR Antikörper) specimens is negatively correlated with the levels of IFIT2 (zeige IFIT2 Antikörper) and pSTAT1
Multilevel genomic analyses of microsatellite instability+ colorectal cancer revealed molecular heterogeneity with clinical relevance, including tumor immunogenicity and a favorable patient outcome associated with JAK1 mutations and the transcriptomic subgroup CMS1
In this study, chronic UVB irradiation induced the expression of IL-10 (zeige IL10 Antikörper) and JAK1 that eventually activates the STAT3 (zeige STAT3 Antikörper) which leads to the transcription of proliferative and antiapoptotic markers.
findings reveal a mechanism by which JAK1 function and inflammatory signaling may be suppressed in response to metabolic stress and provide a mechanistic rationale for the investigation of AMPK (zeige PRKAA1 Antikörper) activators in a range of diseases associated with enhanced activation of the JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) pathway.
JAK1-mediated signaling cascades in skin regulate the expression of proteases associated with the maintenance of skin barrier function and demonstrate that perturbation of these pathways can lead to the development of spontaneous pruritic dermatitis.
Small-scale in vivo screening identified several genes, including Cd109 (zeige CD109 Antikörper), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (zeige STAT3 Antikörper) as a critical, pharmacologically targetable effector of CD109 (zeige CD109 Antikörper)-driven lung cancer metastasis
a causal relationship between MLH1 (zeige MLH1 Antikörper)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
High JAK1 expression is associated with Hepatic Fibrosis.
findings demonstrate that clinically relevant doses of the JAK1/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
Data show that CUZD1 (zeige CUZD1 Antikörper) interacts with a complex containing JAK1/JAK2 (zeige JAK2 Antikörper) and STAT5 (zeige STAT5A Antikörper), downstream transducers of prolactin (zeige PRL Antikörper) signaling in the mammary gland.
JAK1 conditional knockout mice will be an invaluable tool to study cytokine signaling during normal development and disease progression in adult animals.
JAK1, JAK2 (zeige JAK2 Antikörper), and JAK3 (zeige JAK3 Antikörper) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.
JAK1 activating mutants are insufficient to drive hepatocellular carcinoma development in vivo.
Porcine reproductive and respiratory syndrome virus -activated TAK-1 (zeige NR2C2 Antikörper) was essential for the activation of JNK (zeige MAPK8 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) pathways and IL-8 (zeige IL8 Antikörper) expression.
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Antikörper)-STAT1 (zeige STAT1 Antikörper)) signaling pathway.
Data show that proinflammatory cytokines induction was ERK1/2 (zeige MAPK1/3 Antikörper) and JNK1 (zeige MAPK8 Antikörper)/2 dependent.
These data suggest that the p38 (zeige MAPK14 Antikörper) and JNK (zeige MAPK8 Antikörper) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
based on the data, we can conclude that JNK (zeige MAPK8 Antikörper) plays an active role in fragmentation of pig oocytes and that p38 MAPK (zeige MAPK14 Antikörper) is not involved in this process
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2 (zeige MAPK1/3 Antikörper), in the neuroretina and retinal arteries.
PP2A (zeige PPP2R2B Antikörper) and AIP1 (zeige PDCD6IP Antikörper) cooperatively induce activation of ASK1 (zeige MAP3K5 Antikörper)-JNK (zeige MAPK8 Antikörper) signaling and vascular endothelial cell apoptosis.
Phorbol 12-myristate 13-acetate activation of ERK (zeige MAPK1 Antikörper) and JNK (zeige MAPK8 Antikörper) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
This is the first report of the genetic polymorphisms of the JAK1 and STAT3 (zeige STAT3 Antikörper) genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
tyrosine-protein kinase JAK1
, jak1 kinase
, Janus protein tyrosine kinase 1
, Janus kinase 1 (a protein tyrosine kinase)
, tyrosine kinase JAK1
, janus kinase 1
, protein tyrosine kinase
, Janus kinase 1
, Tyrosine-protein kinase Jak1
, tyrosine-protein kinase JAK1-like