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sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS.
Relationship between soluble CD25 (zeige IL2RA Proteine) and gene expression in healthy individuals and patients with multiple sclerosis.
Increased serum level of soluble interleukin-2 (zeige IL2 Proteine) receptor is associated with a worse response of metastatic clear cell renal cell carcinoma (zeige MOK Proteine) to interferon alpha (zeige IFNA Proteine) and sequential VEGF (zeige VEGFA Proteine)-targeting therapy.
Data show that interleukin-2 receptor alpha (zeige IL2RA Proteine), tumor necrosis factor receptor 1 (zeige TNFRSF1A Proteine), serum STimulation-2 (IL1RL1 (zeige IL1RL1 Proteine) gene product), and regenerating islet-derived 3-alpha (zeige REG3A Proteine) were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 (zeige IL2RA Proteine) expression and altered IL-2 (zeige IL2 Proteine) signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA (zeige IL2RA Proteine) expression is associated with CRLF2 (zeige CRLF2 Proteine)-rearranged acute lymphoblastic leukemia.
Inhibits CD25 (zeige IL2RA Proteine) translation through regulation of the LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine)-mTOR (zeige FRAP1 Proteine) pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 (zeige IL2RA Proteine) expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 (zeige IL2RA Proteine) expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA (zeige IL2RA Proteine) in men.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha