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Study reevaluated the relationship between CD25 expression and the leukemia-initiating cell (LIC) properties of acute myeloid leukemia (AML) using a patient-derived xenograft model. Leukemic engraftment was observed with both CD25-positive and -negative populations from three of nine CD25-positive AML patients.
low HDL-C levels are associated with increased levels of soluble IL-2R and poorer disease prognosis in patients with malignant lymphoma and adult T-cell leukemia-lymphoma.
Data suggest interleukin 2 receptor subunit alpha (CD25(+))interleukin-7 receptor subunit alpha (CD127(hi)) cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.
We present the case of a patient with IL-10RA mutation who developed encephalopathy after influenza infection. Genetic testing revealed a IL-10RA mutation at the 3' end of exon 4 (c.537G-->A). A cytokine study revealed elevated levels of IL-1 receptor antagonist, IL-2, IL-6, IL-8, IP-10, eotaxin, G-CSF, MCP-1, and IL-10. These findings might reflect an increased risk of severe IAE in patients with IL-10RA mutation.
Low-expression of CD25 on erythroblasts might correlate with anemia in myelodysplastic syndrome (MDS) patients. CD25 could be a specific marker of LSC in MDS, and could involve in the mechanisms of development and progression of MDS
Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation regulates IL2RA expression.
The AA genotype of rs2386841 in IL2RA was associated with the paucibacillary leprosy form in the start population.
Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha.
a significant association was found between IL2RA SNP and susceptibility to alopecia areata in Iranian cohort
The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Chinese.
Higher frequency of IL2RA SNP could not be detected among multiple sclerosis patients. The difference of frequencies was statistically insignificant between groups, probably, due to low power of analysis and inadequate sample size.
Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians.
sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS.
Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis.
Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy.
Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 expression and altered IL-2 signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA expression is associated with CRLF2-rearranged acute lymphoblastic leukemia.
Inhibits CD25 translation through regulation of the LKB1-AMPK-mTOR pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha