Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human IL21 Protein expressed in Escherichia coli (E. coli) - ABIN413500
Yoon, Zhang, Berner, Blom, Choi: Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 2 Pubmed References
serum IL-21 levels at 12 weeks treatment was significantly elevated, which can predict the EVR, and contributes to individualization of antiviral therapy in HBeAg-positive CHB+NAFLD patients.
IL-23 (zeige IL23A Proteine) activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21 (zeige IL17C Proteine).
IL-21 (zeige IL17C Proteine) promotes the survival and CTLA-4 (zeige CTLA4 Proteine) expression of Tregs and enhanced the suppressive capacity of Tregs during HIV infection. These results broaden the understanding of HIV pathogenesis and provide critical information for HIV interventions.
IL-21 (zeige IL17C Proteine) are important in the pathophysiology of chronic rhinosinusitis with nasal polyposis
Data show that interleukin-21-primed cytotoxic T-cell lymphocytes (CTL) with cytotoxic T-lymphocyte associated protein 4 (CTLA-4 (zeige CTLA4 Proteine)) blockade is safe and produces durable clinical responses.
These results indicate that significant increased IL-21 (zeige IL17C Proteine) expression present within the adenoma/CRC (zeige CALR Proteine) microenvironment might have a potential predicating significance for survival time in patients with CRC (zeige CALR Proteine).
IL-21 (zeige IL17C Proteine) modulates the effector functions of T, B and NK cells, which not only have key roles in antitumoral and antiviral immunity but also in exerting major effects on inflammatory responses promoting the development of autoimmune diseases.
CCL21 (zeige CCL21 Proteine)/IL21 (zeige IL17C Proteine)-armed oncolytic adenovirus enhances antitumor activity against TERT (zeige TERT Proteine)-positive tumor cells.
Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 (zeige IL2 Proteine) and engineered K562 cells expressing membrane-bound IL-21 (zeige IL17C Proteine) for cancer immunotherapy.
IL21 (zeige IL17C Proteine) reduction in osteosarcoma patients due to PD-1 (zeige PDCD1 Proteine) and pd-L1 (zeige CD274 Proteine) mediated follicular helper T cells suppression.
IL-6 (zeige IL6 Proteine) is identified as a master regulator of IL-21 in effector CD8 (zeige CD8A Proteine)(+) T cells.
Our work suggests that IL-21 regulates megakaryocyte development and platelet homeostasis. Thus, IL-21 may link immune responses to physiological or pathological platelet-dependent processes.
we identify novel distal regulatory elements in the mouse Il21 locus and demonstrate a dynamic long-range chromatin interaction between the Il21 promoter and these regulatory elements, which contributes to the regulated expression of IL-21
this study shows that IL-21 acts as a potent inhibitor of a IL-17A (zeige IL17A Proteine)-producing T-cell subset during Mycobacterium bovis Bacillus infection
IL-21 may play an important role in the pathogenesis of SSc (zeige CYP11A1 Proteine) as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R (zeige IL21R Proteine).
The data of this study suggested that an increase in astrocyte-derived IL-21 expression in hippocampal subregions following KA-induced seizures may have potent regulatory effects on epileptogenesis.
this study reveals a context-dependent role for IL-21 in sustaining effector phenotype CD8 (zeige CD8A Proteine) T cells and influencing their migratory properties, accumulation, and functions.
Dysregulated development of IL-17 (zeige IL17A Proteine)- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
results demonstrate that, in the setting of lupus-like CD4 (zeige CD4 Proteine) T cell-driven B cell hyperactivity, IL-21 signaling on Ag-specific donor CD8 (zeige CD8A Proteine) T cells is critical for CTL effector maturation whereas a lack of IL-21R (zeige IL21R Proteine) downregulates CTL responses that would otherwise limit B cell hyperactivity and autoantibody production
Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R (zeige IL21R Proteine), and a series of genes associated with TFH cell development and function.
The results revealed that the peak expression of IL6 (zeige IL6 Proteine) and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, interleukin-21 isoform