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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
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Pig (Porcine) IL2 Protein expressed in - ABIN2965535
Stěpánová, Sinkora: The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs. in Developmental and comparative immunology 2011
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
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Human IL2 Protein expressed in - ABIN988056
Yu, Chen, Horton, Bansal, McElrath, Reichman, Goepfert, Jin: Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection. in Journal of medical virology 2006
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN988052
Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease. in Blood 2009
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488
Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN804324
Mendoza-Naranjo, Saéz, Johansson, Ramírez, Mandakovic, Pereda, López, Kiessling, Sáez, Salazar-Onfray: Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN803864
Gakamsky, Luescher, Pramanik, Kopito, Lemonnier, Vogel, Rigler, Pecht: CD8 kinetically promotes ligand binding to the T-cell antigen receptor. in Biophysical journal 2005
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (zeige IL1B Proteine), TNF-alpha (zeige TNF Proteine) or IFN-gamma (zeige IFNG Proteine) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
Data reported that let-7i upregulates IL-2 expression by targeting the promoter TATA-box region, which functions as a positive regulator. In HIV-1 infection, the expression of let-7i in CD4 (zeige CD4 Proteine)(+) T cells is decreased by attenuating its promoter activity. The reduced let-7i miRNA expression led to a decline in IL-2 levels which contributes to CD4 (zeige CD4 Proteine)(+) T cells death.
IL-2 and IL-6 (zeige IL6 Proteine) work together to enhance influenza-specific CD8 (zeige CD8A Proteine) T cell generation responding to live influenza virus in aged mice and humans
Results showed that plasma and mRNA levels of IL-2, IFN-gamma (zeige IFNG Proteine), IL-4 (zeige IL4 Proteine), and IL-17A (zeige IL17A Proteine) in primary immune thrombocytopenia patients did not change significantly after TPO (zeige THPO Proteine)-RA treatment, whereas TGF-beta1 (zeige TGFB1 Proteine) levels increased remarkably.
the aim of the current review article is to determine the roles of IL-2 IL-2/IL-2R interaction in polyoma BK virus reactivation and PBK (zeige PBK Proteine) associated nephropathy complications.
Modulation of IL-2, IL-4 (zeige IL4 Proteine), IFN-gamma (zeige IFNG Proteine) and/or TNF-alpha (zeige TNF Proteine) levels, or inhibitors of Erk1/2 or S6K1 (zeige RPS6KB1 Proteine) may be a new approach to prevent BAFF (zeige TNFSF13B Proteine)-induced aggressive B-cell malignancies.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 (zeige IL2RA Proteine) expression and altered IL-2 signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
a role for circulating IL-2 in liver dysfunction and propose that a combined assessment of AST/ALT in conjunction with IL-2 at the early stages of symptomatic DENV infection may be useful to predict the severe forms of dengue.
Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity
the central biological role of the novel IL-2-R/Lck (zeige LCK Proteine)/PLCgamma/PKCtheta (zeige PRKCQ Proteine);/alphaPIX (zeige ARHGEF6 Proteine)/Rac1/PYGM (zeige PYGM Proteine) signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.
F42K can circumvent the expansion and negative immunoregulatory effects of highly suppressive ICOS (zeige CTLA4 Proteine)+ Tregs, while promoting NK cell expansion and function. F42K also induces a unique gene expression profile and does not activate many IL2-induced genes, although it has the capacity to activate NK cells and NK cell-associated activation genes, costimulatory molecules, and NK-mediated cytolytic function
Genetic ablation of the IL2Rbeta chain on CD8 (zeige CD8A Proteine)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (zeige CD244 Proteine) and Tim-3 (zeige HAVCR2 Proteine); precludes terminal differentiation of highly defective PD-1 (zeige PDCD1 Proteine)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (zeige IL7 Proteine)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 (zeige IL15 Proteine) as instigators of CD8 (zeige CD8A Proteine)(+) T-cell exhaustion during chronic viral infe...
this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions.
Data show that PTEN plays a key role in Th17 cell differentiation by blocking IL-2 expression.
AnxA6 (zeige ANXA6 Proteine) regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
NOD Treg cells have an impaired responsiveness to IL-2 that reduces their ability to compete for a limited supply of IL-2.
Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.
At single cell level, IL-2 is binary (digital) and CD25 (zeige IL2RA Proteine) is graded expressed, whereas at population level both parameters show graded expression correlating with the antigen amount.
IL-2/anti-IL-2 complexes protected lupus-prone mice against lupus nephritis by expanding Tregs.
Data indicate that IL-2 can augment the gammadeltaT-17 response in favor of short-lived effectors with limited plasticity, particularly in the presence of IL-1beta (zeige IL1B Proteine) and IL-23 (zeige IL23A Proteine). In this way, IL-2 may act to curtail the innate-like response of gammadeltaT-17 cells upon arrival of IL-2-producing adaptive immune cells at the site of inflammation.
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (zeige STAT3 Proteine) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein