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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
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Pig (Porcine) IL2 Protein expressed in - ABIN2965535
Stěpánová, Sinkora: The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs. in Developmental and comparative immunology 2011
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488
Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014
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Human IL2 Protein expressed in - ABIN988056
Yu, Chen, Horton, Bansal, McElrath, Reichman, Goepfert, Jin: Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection. in Journal of medical virology 2006
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN988052
Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease. in Blood 2009
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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN804324
Mendoza-Naranjo, Saéz, Johansson, Ramírez, Mandakovic, Pereda, López, Kiessling, Sáez, Salazar-Onfray: Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN803864
Gakamsky, Luescher, Pramanik, Kopito, Lemonnier, Vogel, Rigler, Pecht: CD8 kinetically promotes ligand binding to the T-cell antigen receptor. in Biophysical journal 2005
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (zeige IL1B Proteine), TNF-alpha (zeige TNF Proteine) or IFN-gamma (zeige IFNG Proteine) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
Uremia patients receiving maintenance hemodialysis with hospitalacquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP (zeige CRP Proteine), IL2 and TNFalpha (zeige TNF Proteine) levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients.
The simultaneous delivery of multiple proinflammatory payloads to the cancer site conferred protective immunity against subsequent tumor challenges. A fully human homolog of IL2-F8-TNF (zeige TNF Proteine)(mut (zeige MUT Proteine)), which retained selectivity similar to its murine counterpart when tested on human material, may open new clinical applications for the immunotherapy of cancer.
Study found that in SLE patients lymphocyte production of IL-2 did not decrease when compared with that of normal subjects.
Interactions among polymorphisms of IFN-gamma (zeige IFNG Proteine)+874 AA, IL-2-330 TT, IL-10 (zeige IL10 Proteine)-1082 AA, IL10 (zeige IL10 Proteine)--592 AC and IL-4 (zeige IL4 Proteine)-589 CC/CT significantly influenced the clinical progression of the subjects with hepatitis B virus and/or hepatitis C virus infection.
Peripheral blood Tregs failed to effectively utilize IL-2 and had relatively little STAT5 (zeige STAT5A Proteine) phosphorylation in active ankylosing spondylitis.
correction for individual cytokine expression levels revealed qualitative differences of cytokine profiles characterized by significantly increased TNFalpha (zeige TNF Proteine) and decreased IL-2-expressing T-cell proportions in long-term type-1-diabetes patients.
CD45 (zeige PTPRC Proteine) is a regulator of IL-2 synergy in the NKG2D (zeige KLRK1 Proteine)-mediated activation of immature human NK cells
PLX4032, a selective BRAF (zeige BRAF Proteine)-i, has no inhibitory effect either on NK cell proliferation in response to cytokines IL-2 or IL-15 (zeige IL15 Proteine)
Results suggest that IL-6 and IL-2 were influenced non-specifically by the presence of a mental disorder and by demographic variables of gender, ethnicity and BMI. Implications of these findings are discussed, as well as possible long-term impact of the identified interleukin differences on immunologic, inflammatory, neuropsychiatric and other systems.
possible associations between the IL-2 polymorphisms +114 T>G (rs2069763) and -330 T>G (rs2069762) and the development of gastric cancer; these associations were then correlated with the presence of H. pylori; results show that, among patients with H. pylori infection, the -330 GG and +114 TT genotypes are significantly associated with a high risk of developing gastric cancer, as is the -330G/+114T haplotype
Each mutation decreased STAT5 (zeige STAT5A Proteine) binding and altered IL-2-induced Il2ra (zeige IL2RA Proteine) gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression.
Deleting IL-2 in CD11c(high)MHCII(+) cells induces spontaneous colitis resembling human inflammatory bowel disease.
a significant increase in plasma levels of IL-2, IFN-g (zeige IFNG Proteine) and TNF (zeige TNF Proteine)-g was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
WASp knockout mice controlled growth of A20 (zeige TNFAIP3 Proteine) lymphoma cells that naturally produced IL-2.
Tumor growth delays observed by tumor irradiation combined with MVA (zeige MYO5A Proteine)-MUC1 (zeige MUC1 Proteine)-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA (zeige MYO5A Proteine) empty vector.
IL-2 signalling is essential to prevent deletion of CD4SP CCR7 (zeige CCR7 Proteine)+ Helios (zeige ZNFN1A2 Proteine)+ thymocytes at a later developmental stage than Card11 (zeige CARD11 Proteine) is required to prevent deletion. The deletion prevented by IL-2 signalling occurs in a Foxp3 (zeige FOXP3 Proteine)-independent manner.
in vivo targeting of the TNF (zeige TNF Proteine) superfamily receptor TNFRSF25 (zeige TNFRSF25 Proteine) using the TL1A (zeige TNFSF15 Proteine)-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy.
IL-2 and IL-6 (zeige IL6 Proteine) work together to enhance influenza-specific CD8 (zeige CD8A Proteine) T cell generation responding to live influenza virus in aged mice and humans
Genetic ablation of the IL2Rbeta chain on CD8 (zeige CD8A Proteine)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (zeige CD244 Proteine) and Tim-3 (zeige HAVCR2 Proteine); precludes terminal differentiation of highly defective PD-1 (zeige PDCD1 Proteine)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (zeige IL7 Proteine)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 (zeige IL15 Proteine) as instigators of CD8 (zeige CD8A Proteine)(+) T-cell exhaustion during chronic viral infe...
this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions.
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (zeige STAT3 Proteine) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein