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High IL13RA1 expression is associated with Invasive breast Cancer.
in humans and mice indicate, for the first time, a role of interleukin-13 (zeige IL13 Proteine) receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism.
these data suggest that microRNA-143 suppresses IL-13 (zeige IL13 Proteine) activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes
required for induction of the alternative macrophage activation pathway by IL-13 (zeige IL13 Proteine) but not by IL-4 (zeige IL4 Proteine)
analysis of IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine) receptors in cancer biology and discussion of pre-clinical and clinical studies pertaining to recombinant immunotoxins designed to target these receptors [review]
review of IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine) receptor structure, receptor regulation, signaling and experimental therapeutics [review]
Results identified FAM120A (zeige FAM120A Proteine) in the IL13 (zeige IL13 Proteine)/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer.
Data show that high expression of interleukin-4 receptor (zeige IL4R Proteine) IL-4Ralpha correlated with increased recurrence, while interleukin-13 (zeige IL13 Proteine) receptor IL-13Ralpha1 had an inverse relationship to recurrence and survival in oral cavity squamous cell carcinoma patients.
Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13 (zeige IL13 Proteine), demonstrating that IL-13 (zeige IL13 Proteine) was not required for the effect. In contrast, deletion of IL-4 (zeige IL4 Proteine) in mice eliminated the hypoglycemic effect of sIL13ralpha1.
These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.
These data establish for the first time a molecular mechanism by which Mac-1 (zeige ITGAM Proteine) regulates the signaling activity of IL-13 (zeige IL13 Proteine) in macrophages.
CAR T cells killed IL13Ra1- and/or IL13Ra2 (zeige IL13RA2 Proteine)-positive cells in contrast to IL13Ra1- and IL13Ra2 (zeige IL13RA2 Proteine)-negative controls
in neonatal mice, IL-12 (zeige IL12A Proteine) uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 (zeige HAND1 Proteine) differentiation
The extracellular and transmembrane domains of the gammaC and interleukin (IL)-13 (zeige IL13 Proteine) receptor alpha1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine)
IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta (zeige TGFB1 Proteine) induction in response to aeroallergens.
a central role for the IL-13 (zeige IL13 Proteine)/IL-13Ralpha1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of cystic fibrosis transmembrane conductance regulator (zeige CFTR Proteine)
IL-13R alpha 1 is required for allergen-induced airway hyperreactivity and mucus production but not for alternative macrophage activation.
IL-13 (zeige IL13 Proteine) and IL-4 (zeige IL4 Proteine) via IL-13 (zeige IL13 Proteine) receptor alpha1 and the type II IL-4 (zeige IL4 Proteine) receptor have direct roles in asthma pathogenesis
in mouse, Il13ra1 is required for allergen-induced airway hyperreactivity, mucus hypersecretion, and fibrosis but not for alternative macrophage activation.
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
, IL-13 receptor subunit alpha-1
, IL-13R subunit alpha-1
, IL13 receptor alpha-1 chain
, bB128O4.2.1 (interleukin 13 receptor, alpha 1)
, cancer/testis antigen 19
, interleukin-13 receptor subunit alpha-1
, interleukin-13-binding protein
, novel cytokine receptor 4
, interleukin 13 receptor alpha 1
, interleukin 13 receptor alpha chain 1
, interleukin 13 receptor, alpha 1
, interleukin-13 receptor subunit alpha-1-like