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These results provide a new pathway of Th1 (zeige HAND1 Proteine) response regulation where IL-12 (zeige IL12A Proteine) secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.
in neonatal mice, IL-12 (zeige IL12A Proteine) uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 (zeige HAND1 Proteine) differentiation
Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 (zeige STAT1 Proteine) activation helped ensure that Treg cells do not readily complete STAT4 (zeige STAT4 Proteine)-dependent Th1 (zeige HAND1 Proteine) cell development and lose their ability to suppress effector T cell proliferation.
Signaling through the IL-35 receptor required the transcription factors STAT1 (zeige STAT1 Proteine) and STAT4 (zeige STAT4 Proteine).
Data show that T(H)1 differentiation was impaired in Il2 (zeige IL2 Proteine)(-/-) T cells but was restored by IL-12Rbeta2 expression.
gamma rays cause a decrease in IFN-gamma (zeige IFNG Proteine), IL-12p70, IL-12 (zeige IL12A Proteine) receptor beta2, and STAT4 (zeige STAT4 Proteine) and an increase in IL-4 (zeige IL4 Proteine) in natural killer cells
Freshly isolated ex vivo T helper (Th)17 cells display restricted expression from Il12rb2 due to the presence of repressive chromatin remodeling.
T-bet mediates STAT1 (zeige STAT1 Proteine)-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2.
NO activates soluble guanylyl cyclase, leading to the up-regulation of cGMP, which selectively induces the expression of IL-12 (zeige IL12A Proteine) receptor beta2.
Contrary to the expectation that the absence of IL-12RB2 would protect from experimental autoimmune encephalitis, IL-12RB2-deficient mice develop earlier and more severe disease, with extensive demyelination and central nervous system inflammation.
The Cox (zeige COX8A Proteine) proportional hazard models revealed that IL12Rb2 and p38MAPK (zeige MAPK14 Proteine) predicted a long OS. To the best of our knowledge, the present study is the first to reveal a close association between IL12Rb2 and p38MAPK (zeige MAPK14 Proteine), and their possible function in nonsmall cell lung cancer progression
Tumor cell differentiation is associated with TILs' expression of IL-12Rbeta2, and an IL-12Rbeta2(+) TIL (zeige TLR1 Proteine) ratio >/=35%) indicates favorable prognosis in LC
inhibition of the H3K27 demethylase (zeige MBD2 Proteine) JMJD3 in naive CD4 (zeige CD4 Proteine) T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 (zeige JAK2 Proteine) and IL12RB2, are regulated by H3K27me3.
this study identified susceptibility single nucleotide polymorphisms in IL12RB2 with Behcet's disease in Han Chinese
In ankylosing spondylitis, conditional analysis identified rs11209032 as the probable causal single-nucleotide polymorphism within a 1.14 kb putative enhancer between IL23R (zeige IL23R Proteine) and IL12RB2. The rs11209032 single-nucleotide polymorphism downstream of IL23R (zeige IL23R Proteine) forms part of an enhancer, allelic variation of which may influence Th1 (zeige TH1L Proteine)-cell numbers.
The results of this case-control study suggest that IL-12A (zeige IL12A Proteine), IL-12B (zeige IL12B Proteine), IL12RB1 (zeige IL12RB1 Proteine), IL12RB2 and IL23R (zeige IL23R Proteine) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations
study confirmed the relationship of IL12RB2 polymorphisms with primary biliary cholangitis (PBC (zeige DLAT Proteine)) susceptibility; provided evidence that IL12RB2 polymorphisms are associated with liver cirrhosis and an increased concentration of disease-specific anti-mitochondrial antibodies in sera of PBC (zeige DLAT Proteine) patients
this study shows that single nucleotide polymorphisms of the IL23R-IL12RB2 region are associated with Behcet's disease in a Northern Chinese Han population
IL12RB2 polymorphisms correlate with risk of lung adenocarcinoma.
The effects of rs3762315 and rs3762316 single nucleotide polymorphisms in 5' flanking region on IL12RB2 transcription
Four SNPs in IFNGR2 (zeige IFNGR2 Proteine), IL12RB1 (zeige IL12RB1 Proteine), IL12RB2, and IL23R (zeige IL23R Proteine) were found to be associated with the MAP infection status of the resource population.
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
interleukin 12 receptor, beta 2
, interleukin 12 receptor beta-2
, interleukin-12 receptor subunit beta-2
, interleukin-12 receptor subunit beta-2-like
, IL-12 receptor subunit beta-2
, IL-12R subunit beta-2
, interferon response to microorganisms
, interleukin-12 receptor beta-2 chain
, interleukin-12 receptor beta 2
, IL-12 receptor beta-2