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The results presented here reveal an additional function in classic IL-11 signaling, highlighting the importance of the IL-11R stalk in IL-11 signaling
The results indicate that miR-23b regulates IL-11 and IL-11Ralpha expression, and it might act as an anti-oncogenic agent in the progression of Hepatocellular Carcinoma by directly downregulating IL-11 expression.
we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex.
Cancer-associated fibroblasts treated with cisplatin facilitate chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway.
The D2 domain of the IL-11R contains two N-linked glycans, which are dispensable for its biological activity, but differentially control maturation and intracellular trafficking of the receptor.
High IL11RA expression is associated with endometrioid tumours.
Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas.
Data suggest domains D1-D3, which contain cytokine binding module, determine which cytokine can activate interleukin-6 or interleukin-11 alpha-receptor subunits; stalk, transmembrane, or intracellular regions do not participate in ligand selectivity.
Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma.
These results indicate that IL-11Ralpha is a potential target for the development of molecular targeted therapy and noninvasive tumor imaging in human osteosarcoma.
Constructed a designer cytokine Hyper IL-11 (H11), which is exclusively composed of naturally existing components. It contains the full length sIL-11Ralpha connected with the mature IL-11 protein, and acts as an agonist on cells expressing the gp130 molec
IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population.
data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases
IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma.
IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense
expression and function in human endometrium
the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells
IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer.
interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma
High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
In spite of clear changes in the temporal expression of both IL-11 and its receptor, no significant differences in motor function are found after spinal cord injury.
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
Demyelination and oligodendrocyte death are exacerbated in IL-11 receptor alpha-deficient mice, suggesting avenues to enhance oligodendrocyte viability and restrict central nervous system inflammation in multiple sclerosis.
This study underlines the importance of gp130 cytokines in proliferation and establishes its role in auto-paracrine pituitary growth regulation.
IL-13-induced lung inflammation, remodeling, respiratory failure and death are all diminished in mice deficient in the IL-11 receptor alpha-gp130 complex.
IL-11 signaling is clearly required for normal bone turnover and normal trabecular bone mass, yet not for the effects of estradiol or estrogen deficiency on the skeleton.
These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua.
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.
IL-11 receptor subunit alpha
, IL-11R subunit alpha
, interleukin-11 receptor alpha chain
, interleukin-11 receptor subunit alpha
, interleukin 11 receptor alpha chain
, interleukin 11 receptor, alpha
, Interleukin-11 receptor alpha chain
, IL-11 receptor subunit alpha-1
, IL-11R subunit alpha-1
, enhancer trap locus homolog 2
, interleukin 11 receptor, alpha chain 2
, interleukin-11 receptor subunit alpha-1
, locus 2
, novel cytokine receptor 1