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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
this is the first study using population epidemiological methods to elucidate the role of gut (zeige GUSB Proteine) microbiota-related dietary factors and polymorphisms in miRNA-binding site in IL13 in CRC (zeige CALR Proteine).
Substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans.
IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy.
SOCS1 (zeige SOCS1 Proteine) inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD (zeige ARCN1 Proteine) in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD (zeige ARCN1 Proteine) in Caucasians but not in Asians.
the IL13-1112 C/T (rs1800925) polymorphism does not predict responsiveness to neoadjuvant chemoradiotherapy or prognosis of Chinese Han patients with locally advanced rectal cancer .
Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma
secretion of IL-13 and amphiregulin (zeige AREG Proteine) suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
Increased baseline mRNA levels of the Th2-related cytokine IL-13 and the regulatory cytokine IL-10 (zeige IL10 Proteine) predicted a positive food challenge outcome.
the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1 (zeige CHI3L3 Proteine)+ alternatively activated macrophages, at (acinar-to-ductal metaplasia [ADM (zeige ADM Proteine)]), which then gives rise to pancreatic intraepithelial neoplasia lesions, is reported.
Data indicate that interleukin-33 (IL-33 (zeige IL33 Proteine))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (zeige IL4 Proteine) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (zeige SULT2A1 Proteine) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (zeige IL4 Proteine) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (zeige HAND1 Proteine) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (zeige MIF Proteine)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (zeige GATA3 Proteine) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (zeige TLR4 Proteine) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (zeige MMP1 Proteine) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600