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Human IFNA1 Protein expressed in Escherichia coli (E. coli) - ABIN413375
Sen, Che, Rajamani, Zerboni, Sung, Ptacek, Arvin: Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2012
Taken together, this work suggests that IFNa (zeige IFNA Proteine) provides protection of salmon against SAV3 locally in an infected area while IFNb (zeige IFNB1 Proteine) and IFNc provides systemic protection against the virus.
IFNa (zeige IFNA Proteine) is the main IFN subtype induced through salmon RIG-I (zeige DDX58 Proteine)/viral RNA receptor MDA5 (zeige IFIH1 Proteine) pathway in lymphoid tissues.
These findings also identify STAT3 (zeige STAT3 Proteine) as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha (zeige IFNA Proteine) responsiveness.
the close association between the increased proportion of CD180 (zeige CD180 Proteine)-negative B cells and the activation of IFN-alpha (zeige IFNA Proteine) signaling in Systemic lupus erythematosus, is reported.
IL-12 (zeige IL12A Proteine) and IFN-alpha (zeige IFNA Proteine) differentially program CD8 (zeige CD8A Proteine) T cells to re-express distinct levels of PD-1 (zeige PDCD1 Proteine) upon re-encountering Ag, resulting in IL-12 (zeige IL12A Proteine)-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag.
The expansion of CD8 (zeige CD8A Proteine) T cells depends on type I IFN, type I IFN and IL-12 (zeige IL12A Proteine) or is largely independent of the two cytokines.
A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity.
Knockdown of endogenous guanylate binding protein (GBP)4 (zeige GBP4 Proteine) increases IRF7 (zeige IRF7 Proteine)-mediated IFN-alpha (zeige IFNA Proteine) production, whereas overexpression of GBP4 (zeige GBP4 Proteine) has the opposite effect.
Data show that similar T cell expansion and serum IgG responses were observed in adenovirus (Adv (zeige AVIL Proteine))-IFN-treated WT and BAFF (zeige TNFSF13B Proteine)-deficient mice despite their disparate pathological and clinical responses.
Studies in both mice and humans have demonstrated a role for IFN-alpha (zeige IFNA Proteine)/beta in directly influencing the fate of both CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cells during the initial phases of antigen recognition.
IFN-alpha (zeige IFNA Proteine) enhances both the induction and maintenance of programmed cell death (PD)-1 (zeige PDCD1 Proteine) expression on T cell receptor-engaged primary mouse T cells through association of IFN-responsive factor 9 (IRF9 (zeige IRF9 Proteine)) with the IFN stimulation response element.
This article reports the production of interferon alpha (zeige IFNA Proteine)/beta (IFN-alpha (zeige IFNA Proteine)/beta) by SJL/J mouse brain astrocyte cultures infected with Theiler's murine encephalomyelitis virus (TMEV).
the polymorphic variant of IFNA1 (-2) gene is associated with chronic HBV infection
Cerebrospinal fluid interferon alpha (zeige IFNA Proteine) levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals.
Data suggest a central role of XBP1 (zeige XBP1 Proteine) in TLR7 (zeige TLR7 Proteine)-induced IFNalpha production and identify XBP1 (zeige XBP1 Proteine) as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
Study shows IFN-alpha (zeige IFNA Proteine) rapidly induces a profound shift in whole brain network structure, impairing global functional connectivity and the efficiency of parallel information exchange.
The review focuses on the value of the type I and III interferon (zeige IFNA Proteine) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
MiR (zeige MLXIP Proteine)-181a is an important mediator for interferons-induced SAMHD1 (zeige SAMHD1 Proteine) expression in astrocytes and microglia, but not for inhibition of HIV-1 infection induced by IFN-alpha (zeige IFNA Proteine).
the expression of certain TAM (zeige CCNA1 Proteine) components was reduced as a result of prolonged degradation of MYD88 (zeige MYD88 Proteine) by Porphyromonas gingivalis infection.
Type I interferons (IFNs) signature is seen in a significant proportion of anti-nuclear antibody-positive (ANA (zeige BTG3 Proteine)(+) individuals and appears to be associated with ANA (zeige BTG3 Proteine) titre and type of autoantibodies, rather than with the presence or development of clinical systemic autoimmune rheumatic diseases (SARDs) symptoms.
study found that endogenous IFNalpha autocrinally promotes the expression of Interferon (zeige IFNA Proteine)-Stimulated Gene (ISG) mRNAs in IL-3 (zeige IL-3 Proteine)-, but not in IFNlambda3 plus IL-3 (zeige IL-3 Proteine)-, treated plasmacytoid dendritic cells (pDCs); production of IFNalpha by IFNlambda3 plus IL-3 (zeige IL-3 Proteine)-treated pDCs is mostly dependent on endogenously produced TNFalpha (zeige TNF Proteine)
results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (zeige IKBKE Proteine) and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 (zeige STAT1 Proteine) degradation.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 (zeige IRF3 Proteine) and subsequent degradation of IRF-3 (zeige IRF3 Proteine), leading to downregulation of IFN-alpha (zeige IFNA Proteine)/beta production.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (zeige IFNA Proteine)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (zeige IFNA Proteine) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.
Expression of Mx protein (zeige MX2 Proteine) and interferon-alpha (IFN-alpha (zeige IFNA Proteine)) was examined by immunohistochemistry in pigs experimentally infected with swine influenza virus.
Foot-and-Mouth Disease Virus inhibits IFN-alpha (zeige IFNA Proteine) expression in infected cells by blocking cap-dependent translation.
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted.
, interferon alpha 1
, interferon alpha 13
, interferon alpha family gene 1
, interferon alpha-1
, IFN-alpha 1
, interferon-alpha 1
, IFN-alpha 1b
, interferon alpha 1b
, interferon alpha-D
, leIF D