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anti-Human HTR7 Antikörper:
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Cat (Feline) Polyclonal HTR7 Primary Antibody für IEM, ICC - ABIN617922
Contesse, Lenglet, Grumolato, Anouar, Lihrmann, Lefebvre, Delarue, Vaudry: Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland. in Molecular pharmacology 1999
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Dog (Canine) Polyclonal HTR7 Primary Antibody für ICC, IF - ABIN188708
Mahé, Bernhard, Bobirnac, Keser, Loetscher, Feuerbach, Dev, Schoeffter: Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines. in British journal of pharmacology 2004
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Dog (Canine) Polyclonal HTR7 Primary Antibody für WB - ABIN537341
Mahé, Loetscher, Dev, Bobirnac, Otten, Schoeffter: Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. in Neuropharmacology 2005
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Human Polyclonal HTR7 Primary Antibody für IHC (p) - ABIN2477210
Sidell: What to do in case of an unthinkable chemical warfare attack or accident. in Postgraduate medicine 1990
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Human Polyclonal HTR7 Primary Antibody für IHC (p) - ABIN2477211
Strasser: Pulmonary function tests, histories keys to recognizing lung disorders. in Occupational health & safety (Waco, Tex.) 1990
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Human Polyclonal HTR7 Primary Antibody für ELISA, WB - ABIN4276907
Sjögren, Svenningsson: Depletion of the lipid raft constituents, sphingomyelin and ganglioside, decreases serotonin binding at human 5-HT7(a) receptors in HeLa cells. in Acta physiologica (Oxford, England) 2007
Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Galphas upon receptor activation.
The dizygotic twins presented here carry a compound heterozygous variant in the HTR7 gene. No other coding sequence abnormalities (CNVs and SVs) were observed in their fully sequenced genomes consistent with either dominant or recessive inheritance. This provides a first suggestive genetic link between the 5-HT7 receptor and autism spectrum disorder in patients.
Placental expression of HTR7 was significantly increased in women with pre-eclampsia compared to controls.
PTP1B directly regulates STAT5 phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 receptor is involved in the suppression of beta-casein expression in MCF-12A cells
Study shows that HTR7 variants are not related to the overall improvement in schizophrenia symptoms following perospirone or aripiprazole treatment
Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
This is a review of literature about how 5-HT7 receptor has been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety and depression
Genetic variations in HTR7 serotonin receptor contribute to the predisposition for alcohol dependence.
There is a cross-reactivity between 5-HT7 and 5-HT1A receptors and in this review they are shown to have a role in depressive disorders.
Serotonin skews human macrophage polarization through HTR2B and HTR7.
the expression of 5-HT7 receptors in brain tissues was higher in the epilepsy group compared with the nonepileptic group; the results suggested that 5-HT7 receptors participate in the pathogenesis of temporal lobe epilepsy
The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor.
The role of the 5-HT7 receptor in the central nervous system, is discussed.
The association with rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 x 10), implicates the serotonergic system in the neurophysiological underpinnings of theta event-related brain oscillations.
Ability of non-inactivating drugs to bind h5-HT(7) orthosteric sites and reverse wash-resistant effects of risperidone/9-OH-risperidone, also bound to h5-HT(7) orthosteric sites, is evidence for protomer-protomer interactions between h5-HT(7) homodimers.
HEK293 cells stably or transiently expressing either of the 5-HT7 receptor splice variants show elevated basal adenylyl cyclase (AC) activity as well as concentration-dependent inhibition of basal AC activity by 5-HT7 antagonists (inverse agonism).
report the activation of the extracellular signal-regulated kinases (ERKs) 1 and 2 (p44 and p42 MAP kinase) through the human serotonin receptors 5-HT(4(b)) and 5-HT(7(a))
Expression in cultured skin cells.
The decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation.
HTR7 is a susceptibility gene for schizophrenia in this Japanese group.
5-HT(7)Dro activity is essential for normal courtship and mating behaviors in the fly
Downregulation of the 5-HT7 receptor in the medial prefrontal cortex (mPFC) improves neonatal administration of phencyclidine-induced attentional deficits and impulsive-like overresponding and exacerbates compulsivity. These results suggest that 5-HT7R is involved in the cognitive outcomes of schizophrenia-like symptoms similar to humans.
The present study demonstrated that acute heroin administration resulted in robust disruptions in attention, impulsivity and motivation in mice.
The underlying molecular machinery involves 5-HT7R-mediated activation of MMP-9, which leads to CD44 cleavage followed by Cdc42 activation.
The results of this study provide evidence for the essential role of the 5HT7R in the acquisition of an allocentric strategy and in the ability to learn concomitantly both strategies.
The data of this study suggest that the 5-HT7R-mediated structural reorganization during the postnatal development might have a crucial role for the development and plasticity of forebrain areas such as cortex and striatum.
this study shows that 5-HT7 is expressed in the liver in vivo and in vitro in CCl4-induced damage, and that 5-HT7 receptor agonist but not the antagonist shows hepatoprotective effect against liver fibrosis
5-HT6/7 receptor antagonist ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
results indicate that there is a crucial role for 5-HT7R-Cdc42-mediated signaling in the regulation of dendritic cell morphology and motility, suggesting that 5-HT7R could be a new target for treatment of a variety of inflammatory and immune disorders.
5-HT7 is required for multiple actions of serotonin in the mammary glands.
Activation of HTR7 promoted opening of the ion channel TRPA1, which in turn triggered itch behaviors. Acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1, as did development of atopic dermatitis.
It indicated that Correlation between nAChalpha4-, 5-HT1A- and 5-HT7-containing receptors and latencies on day 16 may point to a probable link in extinction mechanisms.
Blockade of 5-HT7R Results in Increased Severity of Chronic DSS-induced Colitis.
data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition.
These results indicate that 5-HT receptors are functionally expressed in a subpopulation of substantia gelatinosa neurons of the and activation of 5-HT receptors plays an important role in modulating orofacial nociceptive processing.
The results provide evidence that lurasidone can act as a 5-HT7 receptor antagonist and provide a possible explanation for its antidepressant effect.
Colitis severity was significantly lower in 5-HT7(-/-) mice.
5-HT7 receptor functionally involved in the development of stress adaptation.[review]
Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking.
5-HT(1A) receptors inhibit CA3-CA1 synaptic transmission acting both pre- and postsynaptically, whereas 5-HT(7) receptors enhance CA3-CA1 synaptic transmission acting exclusively at a postsynaptic site.
Activation of the serotonin 5-HT7 receptor promotes synaptogenesis and enhances synaptic activity in hippocampal neurons at early postnatal stages.
The 5-HT7 receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR) to ACh in guinea-pigs.
excitatory 5-HT(2A) and inhibitory 5-HT(7) are present in the uterus of non-pregnant pigs. Endogenous 5-HT containing cells are mainly present in uterine glands of the pig
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.
, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
, 5-hydroxytryptamine receptor 7
, serotonin receptor
, serotonin receptor 1
, serotonin receptor 7
, 5-HT7-like serotonin receptor
, high affinity serotonin receptor (5HT7)
, 5-hydroxytryptamine7 receptor
, 5-HT receptor 7a
, serotonin 5-hydroxytryptamine 7-a receptor
, hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)