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anti-Human HTR2A Antikörper:
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Human Polyclonal HTR2A Primary Antibody für IEM, ICC - ABIN617912
Pootanakit, Prior, Hunter, Brunken: 5-HT2a receptors in the rabbit retina: potential presynaptic modulators. in Visual neuroscience 1999
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Human Polyclonal HTR2A Primary Antibody für IHC (p), WB - ABIN966325
Cook, Fletcher, Wainwright, Marks, Yan, Leventhal: Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. in Journal of neurochemistry 1994
Show all 2 Pubmed References
Human Polyclonal HTR2A Primary Antibody für ELISA, WB - ABIN4276876
Ghadirivasfi, Nohesara, Ahmadkhaniha, Eskandari, Mostafavi, Thiagalingam, Abdolmaleky: Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011
Polyclonal HTR2A Primary Antibody für ELISA, WB - ABIN539784
Zaniewska, McCreary, Przegali?ski, Filip: Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats. in European journal of pharmacology 2007
Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis.
Polymorphisms within the HTR2A gene are associated with asthenozoospermia through sperm count and motility.
Studied the genetic associations of human serotonin receptor gene polymorphism 5-HT2A T102C and behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). The TT genotype was found to be significantly associated with hallucinations, aberrant motor behavior, and psychosis in AD.
In schizophrenia patients, presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone.
The DRD4 and 5HTR2A genes are co-expressed in Peripheral Blood Mononuclear Cells during antipsychotic administration. Despite a correlation between the studied biogenic amine indicators and the psychopathological status of patients, reliable biomarkers of treatment response could not be determined.
Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded.
Imbalance in 5-HT2A may cause significant disturbances that lead to an increased susceptibility to death for individuals who are over 60 years of age.
C102T (rs6313) polymorphism of 5-HTR2A gene may be involved in the susceptibility to suicide, higher number of stressful life and loss events, but A1438G (rs6311) and C1354T (rs6314) polymorphisms of 5-HTR2A gene were not associated with suicide, higher number of stressful life and loss events.
Female anorexia nervosa patients with 5-HT2A -1438AA genotype may be characterized by less severe eating-disordered psychopathological traits in the Chinese Han population.
Studied association of aggression and 5-HTTLPR, 5HTR1A, and 5HTR2A genetic polymorphisms in industrial Russian and traditional Tanzanian population groups.
The polymorphisms in HTR2A and GRIN2B were significantly associated with increased risk of chronic obstructive pulmonary disease.
Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
This study further advances the understanding of genetic variation and behavioral inhibition. Specifically, findings replicated previous associations between variation in the HTR2A and ANKK1 genes and inhibitory control as measured by a stop signal task.
In four monozygotic twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia.
Study assessed role of 5-HT2A receptor to neurophysiological and psychological effects of ayahuasca. Ayahuasca induced an intense inhibitory effect on alpha oscillations in parieto-occipito-temporal cortex that correlated with visual phenomena. 5-HT2A receptor antagonist ketanserin effectively inhibited neurophysiological modifications, reduced correlation between alpha and the visual effects and subjective experience.
These findings suggest that 5-HT promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones
Individuals homozygous for the high-expressing 5-HT2A (T) allele exhibit diminished resting vagal tone-an index of stress vulnerability-when experiencing chronically elevated levels of perceived stress.
A genomic association of the serotonin 2A receptor (5-HT2A) single nucleotide polymorphism (SNP), rs6313 C>T, with SB, where the C allele carrier is associated with a 4.25-fold increased risk of Sleep bruxism.
results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior.
Occupational stress and 5-HTR2A genotypes in workers are associated both independently and in combination with increased risk of poor sleep quality. we found that the C allele of the 5-HTR2A gene and occupational stress are risk factors for poor sleep quality
SMC-rich intima as well as media directly contributes to the hypercontractile response of atherosclerotic vessels through the 5-HT(2A) receptor and the Rho-kinase pathway
Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts.
we showed that gravity changes induced differential modulation of gene expression of BDNF and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
A pre- and post-synaptic distribution of 5-HT2aRs was found in hippocampus, related to facilitation of object memory.
these data demonstrate that sustained SERT loss of function reduces 5-HT2AR surface expression that is critical for the synergistic activation of alphaIIbbeta3 by 5-HT and ADP.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
In the present study we have demonstrated four new principal facts concerning the role of 5-HT2A receptors in thermoregulation
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Data indicate a role of presynaptic 5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A receptor) located at thalamocortical synapses in the control of thalamofrontal connectivity and the associated cognitive functions.
Study showed that acute stress activates 5-HT2AR expression in the mouse cortex and this activation requires the immediate early gene Egr3
Whole-brain mapping and pharmacological screening indicated that serotonin-2A receptor (Htr2a)-expressing cells in the central amygdala (CeA) control both innate and learned freezing, but in opposing directions
Study showed increased expression in striatum membranes and decreased expression in frontal cortex membranes for both DRD2 and Htr2a from heterozygous Reelin mutant mice compared to wild-type
Hippocampal mRNA expression of Htr2a is decreased in serotonin deficient mice after early life stress.
Involvement of 5-HT2 receptors in the expression of withdrawal diarrhea in morphine-dependent mice
Elevated whole-blood 5HT or hyperserotonemia is a consistent finding in approximately 30% of autistic spectrum disorder individuals.
5-HT1A and 5-HT2A receptors are able to modulate each other functional activity by means of bilateral functional cross-talk.
impact of the 5-HT2A and the 5-HT1A receptor for different serotonin syndrome-like responses
Translational and ecological study involving constitutive Htr2a(-/-) knock-out mice and related SNPs in depressed patients suggests that a lower neurotransmission at the 5-HT2AR may favor the susceptibility and severity of major depressive disorder
The results highlight a likely role of the 5-HT2 receptors in allergic airways disease and suggest that 5-HT2 receptor agonists may represent an effective and novel small molecule-based therapy for asthma.
Results of the current study suggest aggression displayed by TLX null and heterozygous mice involves 5-HT(2A/C) receptors.
the serotonin transporter has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Blockade of 5-HT2A receptors strengthens antidepressant effects of escitalopram by enhancing norepinephrine transmission.
5-HT2A receptor subtype is the predominant receptor mediating 5-HT responses in ureteral tissues
The 5-HT(2A) receptor subtype is sensitive to elevated stretch.
Early weaning results in less active behaviour, accompanied by lower 5-HT1A and higher 5-HT2A receptor mRNA expression in specific brain regions.
excitatory 5-HT(2A) and inhibitory 5-HT(7) are present in the uterus of non-pregnant pigs. Endogenous 5-HT containing cells are mainly present in uterine glands of the pig
According to the results obtained, no association between the analysed polymorphism of genes: 5HTR2A (T102C), SLC6A4 (5-HTTLPR) and schizophrenia was found
5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
found enrichment of serotonin receptor 2A mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT2A receptor agonists on responses of V1 neurons.
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
, 5-HT2 receptor
, 5-hydroxytryptamine receptor 2A
, serotonin 5-HT-2A receptor
, 5HT2A receptor
, serotonin receptor 2A
, 5-HT2a receptor
, 5-HT2A receptor
, 5-hydroxytryptamine 2 receptor
, serotonin 5HT-2 receptor
, 5-hydroxytryptamine (serotonin) receptor 2A
, serotonin 2 receptor