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Study demonstrated that the GNAQ p.R183Q mutation resides within endothelial cells in Sturge-Weber syndrome (SWS) brain lesions, and that the SWS brain endothelial cells can be isolated and expanded in culture and further confirm that the GNAQ p.R183Q mutation is present in brain endothelial cells.
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (zeige SOX10 Proteine) expression and presence of the BRAF (zeige BRAF Proteine) V600E mutation.
Mutations in GNAQ and GNA11 (zeige GNA11 Proteine) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (zeige HSPG2 Proteine)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
Data (including data from studies using cells from knockout mice) suggest that CLEC2 (zeige CLEC1B Proteine)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (zeige CLEC1B Proteine) = C-type lectin (zeige MBL2 Proteine) CLEC2 (zeige CLEC1B Proteine); CLEC2R = CLEC2 (zeige CLEC1B Proteine) receptor; GNAQ = guanine nucleotide-binding protein (zeige COASY Proteine) G[q] subunit alpha)
The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (zeige CCR2 Proteine)-stimulated Rho A (zeige RHOA Proteine) GTPase (zeige RACGAP1 Proteine)-mediated serum response factor activation.
GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (zeige YAP1 Proteine) expression. Combined GNAQ/11 and YAP (zeige YAP1 Proteine) may constitute a putative precursor tumour pathway with an activated oncogene (zeige RAB1A Proteine) (GNAQ/11) and downstream effector (YAP (zeige YAP1 Proteine)).
RasGRP3 (zeige RASGRP3 Proteine) mediates ERK MAPK (zeige MAPK1 Proteine) pathway activation in GNAQ mutant uveal melanoma.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige TH1L Proteine) differentiation
The Galphas (zeige GNAS Proteine) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Proteine), respectively. The beta2-AR/Galphas (zeige GNAS Proteine) peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Proteine)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (zeige ADRBK1 Proteine) in complex with Galphaq and Gbetagamma, in which the activated Galpha (zeige SUCLG1 Proteine) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (zeige TGFB1 Proteine) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (zeige IL33 Proteine) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (zeige EIF2AK3 Proteine) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (zeige CA2 Proteine)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (zeige HAND1 Proteine) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (zeige MAPK7 Proteine) signaling pathway to upregulate Cyclin B1 (zeige CCNB1 Proteine) and CDK1 (zeige CDK1 Proteine) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (zeige CRH Proteine) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
The betaARKrgs peptide, but not endogenous GRK2 (zeige ADRBK1 Proteine), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (zeige ADRBK1 Proteine)-based therapeutic approaches to prevent hypertrophy and heart failure.
Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit