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Mouse (Murine) EPO Protein expressed in Escherichia coli (E. coli) - ABIN1305139
JACOBSON, GOLDWASSER, FRIED, PLZAK: Role of the kidney in erythropoiesis. in Nature 1957
Show all 6 Pubmed References
Human EPO Protein expressed in Wheat germ - ABIN1352975
Zhang, Wang, Wang, Shi, Deng, Fu: rhEPO/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-type nano-Au/ZnO sol-gel/nano-Au signal amplification. in Biosensors & bioelectronics 2013
Data show that erythropoietin (EPO) mRNA was upregulated in the lung, from the metamorphic climax (stage 60) onward.
Pro-inflammatory proteins S100A9 (zeige S100A9 Proteine) and tumor necrosis factor-alpha (zeige TNF Proteine) suppress erythropoietin elaboration in myelodysplastic syndromes
Results suggest an interplay of the production and action of hydrogen sulfide (zeige SQRDL Proteine) during hypoxia with subsequent erythropoietin production regulated by HIF-1alpha (zeige HIF1A Proteine) and HIF-2alpha (zeige EPAS1 Proteine).
EPO levels in the coronary artery disease (CAD) group were higher than those in the non-CAD group. The correlation between red cell distribution width and EPO levels was statistically significant among CAD patients.
CD133(+) cells contributed to the local production of erythropoietin, as observed by detection of circulating human erythropoietin. CD133(+) cells appear therefore an effective source for cell repair, able to restore renal functions, including erythropoietin release, and to limit long term maldifferentiation and fibrosis.
Circulating anti-EPO are detected in a significant proportion of treatment-naive HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia.
the T allele of SNP rs60684937 located at 67,419,130 bp on chromosome 17 was associated with increased plasma EPO and a relatively increased expression of a non-coding transcript of PRKAR1A (zeige PRKAR1A Proteine) in sickle cell disease patients
study describes a gain-of-function variant in EPO in an extended kindred with familial erythrocytosis, including 10 affected family members in four generations; this mutation, a single-nucleotide deletion (c.32delG), introduces a frameshift in exon 2
Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 (zeige GATA1 Proteine) transcriptional target, AKAP10 (zeige AKAP10 Proteine), regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
Reduction in central venous blood pressure prompts an increase in plasma EPO concentration independent of hemoconcentration and hence suggests CVP per se as an acute regulator of EPO synthesis
EPO (7q22) and SEC-61 (zeige SEC61A1 Proteine)(7p11) emerged as new candidate genes susceptible to genetic losses with 57.7% deletions identified in regions on chromosome 7.
Compared to wild type (WT) animals, Epo-TAg(h) female mice exhibited higher ventilation in hypoxia. However, when data were separated into luteal and follicular phases of the estrous cycle, basal ventilation and hypoxic ventilation were not different in both mice strains. Experiments with mifepristone (progesterone receptor (zeige PGR Proteine) antagonist) suggest that this effect is independent from the respiratory effects of progesterone.
this study revealed a new mechanism wherein EPO alleviates hepatic steatosis by activating autophagy via SIRT1 (zeige SIRT1 Proteine)-dependent deacetylation of LC3 (zeige MAP1LC3A Proteine).
This study suggests that moderate elevated brain Epo levels provide clinically significant neuroprotection in experimental autoimmune encephalomyelitis without modulation of the immune response making a significant contribution.
The functional role of signal cascades involved in the production of erythropoietin by T cells is determined by the stage of the common adaptation syndrome.
A novel biological pathway has been discovered of soluble biglycan (zeige BGN Proteine) inducing HIF-2alpha (zeige EPAS1 Proteine) protein stabilization and Epo production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
data identify the PHD2 (zeige EGLN1 Proteine):HIF-2alpha:EPO axis as a so far unknown regulator of osteohematology by controlling bone homeostasis.
these data provide strong evidence for a role for G-CSF (zeige CSF3 Proteine) in the development of ACI after burn injury through suppression of EPO signaling in bone marrow erythroid cells.
Data indicated the possible involvement of Jak2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine)/STAT6 (zeige STAT6 Proteine) pathway in the augmentation of EPO on M2 polarization. These results improved the understanding of the immunoregulatory capacity of EPO on macrophages, which might optimize the therapeutic modalities of EPO.
The lack of effect of erythropoietin on hepcidin (zeige HAMP Proteine) expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin administration in both C57BL/6 and mask mice.
EPO expression in myoblasts and myotubes is increased by hypoxia and exercise
EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue.
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
A single intramuscular injection of recombinant adeno (zeige ADORA2A Proteine)-associated virus carrying mutant Epo (R76E) preserves retinal ganglion cells and visual function in glaucomatous mice.
The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver.
characterization of zebrafish epo and epor (zeige EPOR Proteine) demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.