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Mouse (Murine) EPO Protein expressed in Escherichia coli (E. coli) - ABIN1305139
JACOBSON, GOLDWASSER, FRIED, PLZAK: Role of the kidney in erythropoiesis. in Nature 1957
Show all 6 Pubmed References
Human EPO Protein expressed in Wheat germ - ABIN1352975
Zhang, Wang, Wang, Shi, Deng, Fu: rhEPO/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-type nano-Au/ZnO sol-gel/nano-Au signal amplification. in Biosensors & bioelectronics 2013
Data show that erythropoietin (EPO) mRNA was upregulated in the lung, from the metamorphic climax (stage 60) onward.
study describes a gain-of-function variant in EPO in an extended kindred with familial erythrocytosis, including 10 affected family members in four generations; this mutation, a single-nucleotide deletion (c.32delG), introduces a frameshift in exon 2
Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 (zeige GATA1 Proteine) transcriptional target, AKAP10 (zeige AKAP10 Proteine), regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
Reduction in central venous blood pressure prompts an increase in plasma EPO concentration independent of hemoconcentration and hence suggests CVP per se as an acute regulator of EPO synthesis
EPO (7q22) and SEC-61 (zeige SEC61A1 Proteine)(7p11) emerged as new candidate genes susceptible to genetic losses with 57.7% deletions identified in regions on chromosome 7.
The current controversy may derive from a context-dependent mode of action of Epo, namely opposite skeletal actions during bone regeneration and steady-state bone remodeling.
High EPO expression is associated with monoclonal gammopathy of undetermined significance and multiple myeloma.
age 3 plasma levels of EPO were found related to childhood asthma
EPO induces an EMT (zeige ITK Proteine)-like process in mammary non-tumorigenic epithelial cells
these results suggested that quercetin's cytoprotective effects in HepG2 cells are mediated via EPO production.
Serum Epo and VEGF (zeige VEGFA Proteine) may be markers of severity of hypoxia-ischaemia and brain injury as they are closely related to hypoxic exposure.
A novel biological pathway has been discovered of soluble biglycan (zeige BGN Proteine) inducing HIF-2alpha (zeige EPAS1 Proteine) protein stabilization and Epo production presumably in an oxygen-independent manner, ultimately giving rise to secondary polycythemia.
data identify the PHD2 (zeige EGLN1 Proteine):HIF-2alpha:EPO axis as a so far unknown regulator of osteohematology by controlling bone homeostasis.
these data provide strong evidence for a role for G-CSF (zeige CSF3 Proteine) in the development of ACI after burn injury through suppression of EPO signaling in bone marrow erythroid cells.
Data indicated the possible involvement of Jak2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine)/STAT6 (zeige STAT6 Proteine) pathway in the augmentation of EPO on M2 polarization. These results improved the understanding of the immunoregulatory capacity of EPO on macrophages, which might optimize the therapeutic modalities of EPO.
The lack of effect of erythropoietin on hepcidin (zeige HAMP Proteine) expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin administration in both C57BL/6 and mask mice.
EPO expression in myoblasts and myotubes is increased by hypoxia and exercise
these findings define a cis (zeige CISH Proteine)-regulatory enhancer network for Epo signaling during erythropoiesis, and provide the framework for future studies involving the interplay of epigenetics and Epo signaling.
FOXD1 (zeige FOXD1 Proteine) lineage renal interstitial cells consist of distinct subpopulations that differ in their responsiveness to Phd2 (zeige EGLN1 Proteine) inactivation and thus regulation of HIF-2 activity and EPO production under hypoxia or conditions of pharmacologic or genetic PHD (zeige PDC Proteine) inactivation.
This study suggests a possible role of EPO in embryonic endodermal development and a new agent for directing the differentiation into endodermal lineages like pancreatic beta-cells.
Smad1 (zeige SMAD1 Proteine) and Smad5 (zeige SMAD5 Proteine) have overlapping functions to govern hepcidin (zeige HAMP Proteine) transcription. Moreover, erythropoietin and erythroferrone target Smad1 (zeige SMAD1 Proteine)/5 signaling and require Smad1 (zeige SMAD1 Proteine)/5 to suppress hepcidin (zeige HAMP Proteine) expression.
EPO might play a role as a survival factor or as a mitogen in developing cartilage tissue.
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
A single intramuscular injection of recombinant adeno (zeige ADORA2A Proteine)-associated virus carrying mutant Epo (R76E) preserves retinal ganglion cells and visual function in glaucomatous mice.
The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver.
characterization of zebrafish epo and epor (zeige EPOR Proteine) demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.