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Cytokines of the LIF (zeige LIF Proteine)/CNTF family and metabolism
High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration.
CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRalpha-LIFRbeta-gp130 receptor.
Human CNTF expression through lentiviral gene transfer in the rat striatum significantly decreased the levels of neuronal metabolites (N-acetyl-aspartate, N-acetyl-aspartyl-glutamate (zeige GRIN1 Proteine), and glutamate (zeige GRIN1 Proteine)).
the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma (zeige ARHGEF16 Proteine) cells and the underlying molecular mechanism of this effect were investigated for the first time
R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR (zeige LIFR Proteine).
In this review, CNTF plays an important role in neurogenesis and differentiation of neural stem cells.
The levels of expression and secretion of BDNF and CTNF of induced cells were assessed using immunocytochemical, Real-Time polymerase chain reaction, and enzyme linked immunosorbent assay (ELISA).
CNTF elevated in umbilical cord blood from pre-eclamptic pregnancies
CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells.
HGF (zeige HGF Proteine) supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha (zeige CNTFR Proteine); and Artemin (zeige ARTN Proteine) acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3 (zeige GFRA3 Proteine)/Syndecan-3 (zeige SDC3 Proteine) activation.
Study provides new insights into the role of CNTF on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of up-regulation of matrix metalloproteinases through the Akt (zeige AKT1 Proteine) signaling pathway.
data suggest that All-trans retinoic acid administration upregulates CNTF expression in retinal pigment epithelial cells.
Our data reveal that haematopoietic cell-derived CNTF has roles in regulating BM B cell lymphopoiesis and both trabecular and cortical bone, the latter in a sex-dependent manner.
CNTF is upregulated in the corticospinal tract after unilateral pyramidotomy, which likely triggers sprouting of uninjured axons.
Results suggest that slowly up-regulated CNTF in the subventricular zone mediates stroke-induced neurogenesis and is counteracted by inflammation
Ciliary neurotrophic factor activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance
STAT3 (zeige STAT3 Proteine) can activate CNTF transcription because it bound to its promoter and FAK (zeige PTK2 Proteine) antagonist-induced CNTF was reduced by blocking STAT3 (zeige STAT3 Proteine).
data indicate that muscle cells secrete abundant TIMP-1 (zeige TIMP1 Proteine), MCP-1 (zeige CPT1B Proteine), and CNTF, and that of these, only CNTF has the ability to suppress osteoblast function and gene expression in a similar manner to myotube-conditioned medium
results suggest that differentiation of distinct types of astrocytes in developing cerebellum may be regulated by ctnf (zeige TNF Proteine) and bmp2 (zeige BMP2 Proteine).
High power microwave exposure may cause acute retinal injury and change the expression of CNTF protein in rabbit retina.
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
ciliary neurotrophic factor
, ciliary neurotropic factor
, growth-promoting activity factor
, zinc finger protein 91 homolog