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High power microwave exposure may cause acute retinal injury and change the expression of CNTF protein in rabbit retina.
Our findings suggest that CNTF over-expression enhances the protective effects of bone marrow mesenchymal stem cells on retinal pigment epithelium cells, thus indicating subretinal-transplantation of CNTF-bone marrow mesenchymal stem cells may be a promising therapy for blue-light -injured retina
Cytokines of the LIF/CNTF family and metabolism
High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration.
CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRalpha-LIFRbeta-gp130 receptor.
Human CNTF expression through lentiviral gene transfer in the rat striatum significantly decreased the levels of neuronal metabolites (N-acetyl-aspartate, N-acetyl-aspartyl-glutamate, and glutamate).
the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells and the underlying molecular mechanism of this effect were investigated for the first time
R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR.
In this review, CNTF plays an important role in neurogenesis and differentiation of neural stem cells.
The levels of expression and secretion of BDNF and CTNF of induced cells were assessed using immunocytochemical, Real-Time polymerase chain reaction, and enzyme linked immunosorbent assay (ELISA).
CNTF elevated in umbilical cord blood from pre-eclamptic pregnancies
CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells.
Report favourable allelic patterns of ACTN3 and CNTF genes on aerobic performance in athletes.
Data indicate that aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner.
we show that the release of CNTF by glial cells is a very powerful stimulus for optic fiber regeneration and retinal ganglion cell survival after optic nerve crush
Ciliary neurotrophic factor levels were increased in painful PTT only.
Peptide 6c, corresponding to human CNTF amino acid residues 147-150, induces neurogenesis, neuronal activity and proliferation of immature neurons in the dentate gyrus and improvement of spatial reference memory in mice.
CNTF's effects on retinal pigment epithelial (RPE) physiology
Data show that variants in CNTF were significantly associated with a lower age at onset of the eating disorders.
The role played by CNTF in retinal cell differentiation and survival in retinal progenitors, is reported.
Ciliary neurotrophic factor, and related (CNTF), ligands targeting the established CNTF receptor alpha, binds to sortilin with high affinity.
CNTF activates Akt-Nrf2 signaling to protect myocardial cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation.
HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation.
Study provides new insights into the role of CNTF on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of up-regulation of matrix metalloproteinases through the Akt signaling pathway.
data suggest that All-trans retinoic acid administration upregulates CNTF expression in retinal pigment epithelial cells.
Our data reveal that haematopoietic cell-derived CNTF has roles in regulating BM B cell lymphopoiesis and both trabecular and cortical bone, the latter in a sex-dependent manner.
CNTF is upregulated in the corticospinal tract after unilateral pyramidotomy, which likely triggers sprouting of uninjured axons.
Results suggest that slowly up-regulated CNTF in the subventricular zone mediates stroke-induced neurogenesis and is counteracted by inflammation
Ciliary neurotrophic factor activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance
STAT3 can activate CNTF transcription because it bound to its promoter and FAK antagonist-induced CNTF was reduced by blocking STAT3.
data indicate that muscle cells secrete abundant TIMP-1, MCP-1, and CNTF, and that of these, only CNTF has the ability to suppress osteoblast function and gene expression in a similar manner to myotube-conditioned medium
results suggest that differentiation of distinct types of astrocytes in developing cerebellum may be regulated by ctnf and bmp2.
Report intravitreal transplantations of modified neural stem cells as cell based delivery system for CNTF in mouse model of photoreceptor degeneration.
CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
CNTF may play a role in the process of remyelination by inducing the MOG expression.
These studies demonstrate that endogenous CNTF and LIF act centrally to protect axons from acute inflammatory destruction via an oligodendrocyte-independent mechanism.
Both CNTF and its receptor, CNTF-Ralpha, are expressed in skeletal muscle.
study observed that CNTF increased the number of IFN-gamma producing CD4 T cells results indicate CNTF activates the same tripartite receptors in mouse and human cells
CNTF acts as a chemoattractant and participates in the recruitment of endogenous progenitors during myelin repair
CNTF protects mice against streptozotocin-induced diabetes by increasing pancreatic islet survival, and this protection depends on SOCS3. In addition, SOCS3 expression and beta-cell fate are dependent on STAT1/STAT3 ratio.
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
growth-promoting activity factor
, ciliary neurotrophic factor
, ciliary neurotropic factor