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Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1 (zeige TNFRSF1A Proteine), serum STimulation-2 (IL1RL1 (zeige IL1RL1 Proteine) gene product), and regenerating islet-derived 3-alpha (zeige REG3A Proteine) were significantly associated with non-relapse mortality.
Our results show that the frequency of Tregs is altered in a large cohort of long-term T1D patients, a profound decrease in CD25 expression and altered IL-2 (zeige IL2 Proteine) signaling are typical features of Tregs populations in long-term diabetic patients and their relatives.
High IL2RA expression is associated with CRLF2 (zeige CRLF2 Proteine)-rearranged acute lymphoblastic leukemia.
Inhibits CD25 translation through regulation of the LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine)-mTOR (zeige FRAP1 Proteine) pathway to suppress T cells.
Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA in men.
it has been shown that CD25 serves as a negative growth regulator of Chronic myeloid leukemia (zeige BCL11A Proteine) leukemic stem cells.
study provides evidence that membrane-coated microvesicles released by apoptotic neutrophils suppress a subset of resting Th cells by downregulating IL-2 (zeige IL2 Proteine) and IL-2R expression
In T1D, low IL-2 (zeige IL2 Proteine) responsiveness was most pronounced in memory T effector cells. Reduced IL-2 (zeige IL2 Proteine) responses in memory T effector cells were not rescued by resting, remained lower after activation and proliferation, and were absent in type 2 diabetes.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
At single cell level, IL-2 (zeige IL2 Proteine) is binary (digital) and CD25 is graded expressed, whereas at population level both parameters show graded expression correlating with the antigen amount.
Results indicate that conjugated-interleukin-2 (IL2 (zeige IL2 Proteine)) protein derived from NKTR (zeige NKTR Proteine)-214 occupy interleukin-2 (IL2 (zeige IL2 Proteine)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (zeige IL2 Proteine) protein.
CDK6 (zeige CDK6 Proteine)-mediated suppression of CD25 is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Proteine). . Pharmacologic inhibition of CDK6 (zeige CDK6 Proteine) kinase induces CD25 and RUNX1 (zeige RUNX1 Proteine) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.
Combination with anti-programmed cell death protein-1 (PD-1 (zeige PDCD1 Proteine)) antibodies promoted complete tumor rejection, indicating the relevance of CD25 antigen as a therapeutic target and promising substrate for future combination approaches in immune-oncology.
Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 (zeige CD8A Proteine) + CD122 (zeige IL2RB Proteine)+ and CD4 (zeige CD4 Proteine) + CD25+ Treg cells.
glucosamine interferes with N-glycosylation of CD25, and thereby attenuates IL-2 (zeige IL2 Proteine) downstream signaling
Expansion of CD25-expressing innate lymhpoid cells by IL-2 (zeige IL2 Proteine)/anti-IL-2 (zeige IL2 Proteine) complexes leads to a reduction in very low-density lipoprotein cholesterol and atherosclerosis.
our results identify IL-7 (zeige IL7 Proteine) as a necessary factor contributing to sustained CD25 expression at Treg surface in vivo thereby affecting their ability to efficiently react to IL-2 (zeige IL2 Proteine).
Data indicate that the deletion of interferon-gamma (IFN-gamma (zeige IFNG Proteine)) in the CD25 knockout (KO) mice delays glandular destruction and preserves glandular function.
IL2 (zeige IL2 Proteine)-R was equally expressed in interfollicular tissue and in follicles, whereas in moderate and severe cases of postweaning multisystemic wasting syndrome, it was detected in interfollicular remnants only
The appearance of CD25 after activation of porcine dendritic cells, is reported.
Differential expression of CD25 and IDO (zeige IDO1 Proteine) mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 (zeige PTGER4 Proteine) receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 (zeige FOXP3 Proteine) factor in bovine CD8 (zeige CD8A Proteine)(+) cells.
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44 (zeige CD44 Proteine), and CD62L (zeige SELL Proteine) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
Pretreatment of neonatal PBMC with IL-1beta (zeige IL1B Proteine), TNF-alpha (zeige TNF Proteine) or IFN-gamma (zeige IFNG Proteine) promotes mitogenic response to ConA through up-regulating the production of IL-2 (zeige IL2 Proteine) and the expression of the mature IL-2 (zeige IL2 Proteine) receptor.
These findings revealed that despite the existence of a distinct bovine CD4 (zeige CD4 Proteine)(+)CD25(high) T cell population, which showed Foxp3 (zeige FOXP3 Proteine) transcription/expression, natural regulatory activity did not reside in this cell population
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha
, IL-2 receptor alpha subunit
, interleukin 2 receptor, alpha chain
, interleukin-2 receptor alpha chain
, IL-2 alpha receptor
, IL2 receptor alpha
, interleukin-2 alpha receptor
, interleukin 2 receptor alpha chain
, interleukin-2 receptor alpha subunit
, IL-2 Receptor alpha chain
, interleukin 2 receptor, alpha
, IL-2R alpha chain
, p55 chain
, IL-2R alpha
, cytokine receptor
, CD25 antigen