Maus IgG Isotyp-Kontrolle

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Isotyp
Wirt
Maus
175
175
164
141
131
118
84
67
65
63
57
53
51
50
33
23
16
15
11
7
7
4
3
Antikörpertyp
Recombinant Antibody
Applikation
Isotype Control (IsoC), SDS-PAGE (SDS)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Isotyp IgG
Reinigung purified by chromatography
Reinheit > 90 % by SDS-PAGE
Isotyp
Hintergrund Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains (two heavy chains gamma and two light chains). Each IgG has two antigen binding sites. IgG antibodies are involved in predominantly the secondary immune response. The presence of specific IgG, in general, corresponds to maturation of the antibody response. It plays an important role in Antibody-dependent cell-mediated cytotoxicity (ADCC) and Intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol. Recombinant mouse IgG protein, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques.
Synonyms: Immunoglobulin heavy chain constant region gamma 2a, Immunoglobulin G
Molekulargewicht 26.6 kDa (236aa)
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Kommentare

Concentration (detection method): 0.5 mg/mL (determined by Bradford assay)

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer 20 mM Tris-HCl buffer (pH 8.0)
Handhabung Avoid repeated freezing and thawing cycles.
Lagerung 4 °C
Bilder des Herstellers
 image for Mouse IgG isotype control (ABIN1098804) Mouse IgG isotype control
Allgemeine Veröffentlichungen Brüggemann, Teale, Clark, Bindon, Waldmann: "A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 9, pp. 3145-50, 1989 (PubMed).