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Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS (zeige FUS Proteine) to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS (zeige FUS Proteine) interacts with another nuclear matrix-associated (zeige SMARCA5 Proteine) protein, Matrin3.
Data suggest that ERH interacts directly in nucleus with C-terminal Arg-Gly-rich region of SAFB1/SAFB2 and this multimer co-localizes in insoluble nuclear fraction; binding of ERH reverses inhibition exerted by SAFB1/SAFB2 on SRPK1. (ERH = enhancer of rudimentary homolog protein; SAFB = scaffold attachment factor B; SRPK1 = splicing kinase SR protein kinase-1)
The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (zeige MCAM Proteine) (NCAM1 (zeige NCAM1 Proteine)) and ASTN2 (zeige ASTN2 Proteine) was influenced by SAFB1.
Single depletion of either SAFB1 or SAFB2 (zeige SAFB2 Proteine) leads to an increase in expression of the other SAFB protein.
reveals an unexpected role of SUMO-1 (zeige SUMO1 Proteine) and SAFB in the stimulatory coupling of promoter binding, transcription initiation and RNA processing
SAFB1 formed a complex with the histone methyltransferase EZH2 (zeige EZH2 Proteine).
Data indicate that scaffold attachment factor SAFB1 is transiently recruited to DNA breaks in a poly(ADP-ribose)-polymerase 1- and poly(ADP-ribose)-dependent manner.
Results indicate that SAFB1 and SAFB2 (zeige SAFB2 Proteine) are crucial repressors for ERalpha (zeige ESR1 Proteine) dynamics in association with the nuclear matrix and that their synergistic regulation of ERalpha (zeige ESR1 Proteine) mobility is sufficient for inhibiting ERalpha (zeige ESR1 Proteine) function.
transcriptional repressor SAFB1 is modified by both SUMO1 (zeige SUMO1 Proteine) and SUMO2 (zeige SUMO2 Proteine)/3, and this modification is necessary for its full repressive activity.
Data show that binding of p53 (zeige TP53 Proteine) to SAFB1 had a significant functional outcome, since SAFB1 was shown to suppress p53 (zeige TP53 Proteine)-mediated reporter gene expression.
despite a high degree of sequence similarity, SAFB1(-/-) and SAFB2 (zeige SAFB2 Proteine)(-/-) mice do not totally phenocopy each other
Mice lacking SAFB1 exhibit developmental abnormalities in their lungs, high incidence of perinatal lethality, and adults develop different types of tumors. Mouse embryonic fibroblasts from Safb1-null animals are immortalized in culture.
SAFB1 represses ERalpha (zeige ESR1 Proteine) activity via indirect association with histone deacetylation and interaction with the basal transcription machinery
SAFB1 plays a critical role in development, growth regulation, and reproduction.
SAFB1 interacts in pull-down assays not only with PPARgamma (zeige PPARG Proteine) but also with all nuclear receptors tested
SAFB1 loss causes lack of contact inhibition, increased foci formation, and increased oncogene (zeige RAB1A Proteine)-induced anchorage-independent growth.
Our data show that SAFB1 heterozygosity does not influence Wnt-1 (zeige WNT1 Proteine) induced tumorigenesis
These results indicate a major role for SAFB1 in the activation of Srebp-1c (zeige SREBF1 Proteine) through its interaction with RBMX (zeige RBMX Proteine).
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
HSP27 ERE-TATA-binding protein
, HSP27 estrogen response element-TATA box-binding protein
, Hsp27 ERE-TATA binding protein
, glutathione S-transferase fusion protein
, heat-shock protein (HSP27) estrogen response element and TATA box-binding protein
, scaffold attachment factor B1
, scaffold attachment factor B2
, scaffold attachment factor B
, scaffold attachment factor b
, Scaffold attachment factor B