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Rbfox2 modulates the functions of vascular CaV1.2 (zeige CACNA1C ELISA Kits) calcium channel by dynamically regulating the expressions of alternative exons 9* and 33, which in turn affects the vascular myogenic tone.
RBFOX2 dysregulation by dominant-negative RBFOX2 is an early pathogenic event in diabetic hearts.
RBFox2 interactis with chromatin in a nascent RNA-dependent manner. RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repression.
Some of the widespread cellular functions of Rbfox2 protein are attributable to regulation of miRNA biogenesis, and might include the mis (zeige AMH ELISA Kits)-regulation of miR (zeige MLXIP ELISA Kits)-20b and miR (zeige MLXIP ELISA Kits)-107 in cancer and neurodegeneration.
RBFOX proteins can facilitate the splicing of micro-exons. We also found that PTBP1 (zeige PTBP1 ELISA Kits) likely regulates the inclusion of micro-exons, possibly by repressing the inclusion of micro-exons that are enhanced by RBFOX proteins and other splicing factors.[RBFOX]
CPSF2 (zeige CPSF2 ELISA Kits) and SYMPK (zeige SYMPK ELISA Kits), are RBFOX2 cofactors for both inclusion and exclusion of internal exons.
RBFOX2 SNPs showed evidence for effects across multiple reading and language traits.
Results show that the conserved Rbfox2 RNA binding protein regulates 30% of the splicing transitions observed during myogenesis and is required for the specific step of myoblast fusion.
MBNL1 (zeige MBNL1 ELISA Kits) and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.
RBFOX2 polymorphism is associated with breast cancer.
A classic nuclear localization signal at the N terminus that regulates the subcellular localization of Rbfox2 isoforms during differentiation of the mouse epithelial and embryonic stem cells lines has been identified.
Gain- and loss-of-function experiments demonstrated that Rbfox1 (zeige A2BP1 ELISA Kits) and Rbfox2 cooperate in promoting Mef2D (zeige MEF2D ELISA Kits) splicing and subsequent myogenesis.
an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned
During an EMT (zeige ITK ELISA Kits), Rbfox2-regulated splicing shifts from epithelial-to mesenchymal-specific events.
Rbfox2 protein controls a post-transcriptional program required for proper brain development.
the negative regulation of Rbfox2 by Rbfox3 (zeige RBFOX3 ELISA Kits) through a novel mechanism
The present study provides evidence that alternative neuronal nPTB (zeige PTBP2 ELISA Kits) and Fox-1 (zeige A2BP1 ELISA Kits)/Fox-2 isoforms are also produced in lenses
Data show that Rbfox1l and Rbfox2 have unique and redundant roles in splicing regulation.
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
RNA binding motif protein 9
, RNA binding motif protein 9 a
, RNA binding protein fox-1 homolog 2
, RNA-binding motif protein 9
, fox-1 homolog B
, fox-1 homologue
, hexaribonucleotide-binding protein 2
, repressor of tamoxifen transcriptional activity
, RNA-binding protein 9
, Fyn-binding molecule 2
, fox-1 homolog Fxh
, hexaribonucleotide binding protein 2
, Fox-1 homolog B
, RNA binding motif protein 9 b