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Human PARK7 ELISA Kit für Cell ELISA - ABIN2685152
Wang, Yu, Pu, Du: Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. in Molecules (Basel, Switzerland) 2013
Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
DJ-1 is a powerful regulator of reactive oxygen species production as well as NHE1 (zeige SLC9A1 ELISA Kits) expression and activity in CD4 (zeige CD4 ELISA Kits)(+) T cells.
DJ-1 deficiency negatively regulates liver progenitor cells (LPC (zeige PCSK7 ELISA Kits)) proliferation by impairing the formation of LPC (zeige PCSK7 ELISA Kits)-associated fibrosis and inflammatory niches.
regulation of reactive oxygen species (ROS (zeige ROS1 ELISA Kits)) and of the antioxidant protein (zeige PRDX3 ELISA Kits) DJ-1 (PARK-7), which increases with cancer progression and acts to lessen oxidative damage to malignant cells, in relationship with systemic mastocytosis severity, was examined.
Our data strengthen previous findings regarding DJ-1 diverse pathways and indicate that DJ-1 is part of a concerted and complex cellular response to OS
Our data demonstrates that the activation of DJ-1 in response to myocardial I/R injury protects the heart by regulating the SUMOylation status of Drp1 (zeige CRMP1 ELISA Kits) and attenuating excessive mitochondrial fission.
DJ-1(-/-) astrocytes may provide decreased neuroprotection to surrounding neurons due to alterations in pro-inflammatory mediator expression
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
To verify our finding, we provide evidence that the protein expression of Parkinson protein 7, including new protein synthesis, is sensitive to mTORC1 inhibition
Results suggest that overexpression of DJ-1 improves mitochondrial function, at least in part, through a mechanism involving Akt (zeige AKT1 ELISA Kits) phosphorylation on threonine 308.
Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily.
DJ-1 co-aggregating with alpha-synuclein may result from weak hydrophobic interaction and DJ-1 exhibited chaperon-like activity in the initial time of alpha-synuclein aggregation at high temperature.
The effects of variants in the Parkin (zeige PARK2 ELISA Kits), PINK1, and DJ-1 genes along with evidence for their pathogenicity have been summarized. (Review)
genetic analyses of indel loci in ACE (zeige ACE ELISA Kits), DJ-1, and GIGYF2 (zeige GIGYF2 ELISA Kits) genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Downregulation of DJ-1 using DJ-1-siRNA in H69AR cells sensitized cancer cells to chemotherapeutic drugs through increasing drug-induced cell apoptosis accompanied with G0-G1 phase arrest. These findings suggest DJ-1 may serve as a potential biomarker for chemoresistance and prognostic factor for patients with small-cell lung cancer (SCLC).
DJ-1 was highly expressed in the early stage of lung cancer, and its expression was significantly decreased after metastasis. Therefore, DJ-1 may be a potential biomarker for the early diagnosis and monitoring of lung cancer metastasis
DJ-1 overexpression can restore the impaired Nrf2 (zeige GABPA ELISA Kits) pathway, leading to Alveolar type II cell protection in heavy smokers.
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22