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Imp13 forms a ring-like molecule encircling the Mago-Y14 cargo with a conserved interaction surface.
Imp13 is a novel factor that affects neurotransmitter release at the fly neuromuscular junction.
this study significantly expands the repertoire of importin 13 cargoes and sets the basis for a more detailed characterization of this extremely versatile transport receptor.
This is the first report that IPO13 can be phosphorylated at Ser193 and that this modification regulates IPO13 subcellular localization and nucleocytoplasmic transport function, with important implications for IPO13's role in development and other processes.
The anti- glucocorticoid receptor effect of respiratory syncytial virus was mediated by viral nonstructural protein 1, which likely functioned by competing with IPO13 for glucocorticoid receptor binding.
IPO13 influenced intracellular distribution of CTCF.
IPO13 may contribute to the pathogenesis of pterygium via modulation of K17 and c-Jun.
Imp13 is able to bind and export eIF1A in vivo and that its function is essential.
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma.
Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 are decreased in endometrial polyps; however, the expression of bcl-2 was increased in polyps compared to the normal endometrial tissue.
IPO13 is uniquely expressed by human limbal basal epithelial cells, and plays an important role in maintaining the phenotype, high proliferative potential, and less differentiation of corneal epithelial progenitor cells.
Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation.
Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers
IPO13 variation may improve nuclear bioavailability of endogenous glucocorticoids
Interactome of the inhibitory isoform of the nuclear transporter Importin 13 has been reported.
Imp13 contributes to the neural cell-specific cargo trafficking and potentially to other functions during brain development.
IPO13 has a stage-specific role in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.
, complementation group 5
, importin 13
, Ran binding protein 13
, karyopherin 13
, late gestation lung 2
, ran-binding protein 13
, late gestation lung 2 protein