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Human Polyclonal HDAC6 Primary Antibody für ChIP, WB - ABIN2668292
Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. in PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody für IHC, WB - ABIN223301
Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody für IHC (p), WB - ABIN387955
Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 6 Pubmed References
Human Polyclonal HDAC6 Primary Antibody für ELISA - ABIN564313
Xargay-Torrent, López-Guerra, Saborit-Villarroya, Rosich, Campo, Roué, Colomer: Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Monoclonal HDAC6 Primary Antibody für ELISA, WB - ABIN564314
Bantscheff, Hopf, Savitski, Dittmann, Grandi, Michon, Schlegl, Abraham, Becher, Bergamini, Boesche, Delling, Dümpelfeld, Eberhard, Huthmacher, Mathieson, Poeckel, Reader, Strunk, Sweetman, Kruse et al.: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. ... in Nature biotechnology 2011
Human Polyclonal HDAC6 Primary Antibody für ChIP, IP - ABIN4316760
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Human Monoclonal HDAC6 Primary Antibody für FACS, ICC - ABIN4316769
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2 (zeige PLIN2 Antikörper)
HDAC6 is necessary and sufficient for BRP (zeige GDF5 Antikörper) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (zeige TUBA4A Antikörper) proteostasis and disruption of the cardiomyocyte microtubule structure.
From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy
Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.
Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (zeige EHMT2 Antikörper) to modify histone H3K9 and to determine cell fates.
Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
Data show that selective histone deacetylase 6 (HDAC6) inhibition or knockdown of HDAC6 expression was able to prevent caspase 3 (zeige CASP3 Antikörper) activation in lung endothelial cells and maintain lung endothelial cell-cell junctions.
The HDAC6 Inhibitor Tubacin Induces Release of CD133(+) Extracellular Vesicles From Cancer Cells.
MicroRNA-22 Promoted Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting HDAC6
A decrease of HDAC6 expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer.
these results suggest that HDAC1 (zeige HDAC1 Antikörper) and HDAC6 may play a role in clear cell renal cell carcinoma (zeige MOK Antikörper) biology
Genetic abrogation of HDAC6 in primary melanoma (zeige CD274 Antikörper) samples and cell lines, down-regulates the expression of PD-L1, an important co-stimulatory molecule expressed in cancer cells, which activates the inhibitory regulatory pathway PD-1 in T-cells.
activation appears to be a key survival mechanism for HDAC6 inhibitor treatment.
ARID1A (zeige ARID1A Antikörper) mutation inactivates the apoptosis-promoting function of p53 (zeige TP53 Antikörper) by upregulating HDAC6, indicating that pharmacological inhibition of HDAC6 is a therapeutic strategy for ARID1A (zeige ARID1A Antikörper)-mutated cancers.
7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 (zeige SIRT1 Antikörper) activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA). manner in promotion of breast cancer growth.
Findings provide physiological insight into the ciliary role of the CYLD (zeige CYLD Antikörper)/HDAC6 axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
Suppression of HDAC6 enhanced the interaction between HIF-1alpha (zeige HIF1A Antikörper) and HSP70 (zeige HSP70 Antikörper) under hypoxic conditions.
Overall, our results provide the first evidence that HDAC6 is capable of inducing expression of pro-inflammatory genes by regulating the ROS (zeige ROS1 Antikörper)-MAPK (zeige MAPK1 Antikörper)-NF-kappaB (zeige NFKB1 Antikörper)/AP-1 (zeige JUN Antikörper) pathways and serves as a molecular target for inflammation.
MAP3K4 (zeige MAP3K4 Antikörper) activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6.
HDAC6 is a critical regulator of a pro-apoptotic p53 (zeige TP53 Antikörper) K120 acetylation and mitochondrial function in mesenchymal stem cells
HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (zeige CA2 Antikörper)+) levels.
These data thus reveal that HDAC6 represses IL-17 (zeige IL17A Antikörper) production in T cells, providing novel insights into the role of HDAC6 in the immune system.
HDAC6 inhibition reduces tumor growth and PD-L1 (zeige CD274 Antikörper) production in vivo.
Specific HDAC6 inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP (zeige TMPRSS5 Antikörper) levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD.
In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt (zeige AKT1 Antikörper) and activated glycogen synthase kinase (GSK)-3beta (zeige GSK3b Antikörper).
The results suggest that HSI2 recruits MED13 (zeige MED13 Antikörper) and HDA6 to suppress directly a subset of seed maturation genes post-germination.
HDA6 is a component of the TRB2 (zeige TRIB2 Antikörper) complex.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (zeige HELLS Antikörper) at CG dinucleotides.
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (zeige CD86 Antikörper)) in the root tip were affected in hda6 mutation.
HDC1 is a ubiquitously expressed nuclear protein (zeige UBN1 Antikörper) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA6 and FLD (zeige LPIN1 Antikörper) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (zeige MBD2 Antikörper) through HDA6 and FLD (zeige LPIN1 Antikörper) interaction in flowering control.
Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.
HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.
HDA6 and MET1 (zeige DNMT1 Antikörper) interact directly and act together to silence transposable elements by modulating DNA methylation (zeige HELLS Antikörper), histone acetylation, and histone methylation status.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
, histone deacetylase 6
, histone deacetylase HDA2
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6