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As a tumor suppressor, FOXA1 targets PIK3R1 directly to inhibit PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway, thus exerting a negative regulatory effect on proliferation, migration, and invasion of HCC (zeige FAM126A Proteine) in male patients.
miR212 suppresses renal cell carcinoma (zeige MOK Proteine) (RCC (zeige XRCC1 Proteine)) proliferation and invasion by modulating FOXA1, suggesting that miR212 may have potential as a therapeutic target in RCC (zeige XRCC1 Proteine).
the results of the present study suggested that FOXA1 is a potential oncogene (zeige RAB1A Proteine) in NSCLC
During the ensuing weeks, the PAX2 (zeige PAX2 Proteine)/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2 (zeige PAX2 Proteine)-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium
The transcription factor FOXA1 directly bound to the PLOD2 (zeige PLOD2 Proteine) promoter, and turned on PLOD2 (zeige PLOD2 Proteine) transcription. In summary, our findings revealed a regulatory mechanism of NSCLC metastasis through EGFR (zeige EGFR Proteine)-PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)-FOXA1-PLOD2 (zeige PLOD2 Proteine) pathway.
maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
overexpression of GATA3 (zeige GATA3 Proteine) and FOXA1 cooperate with PPAR (zeige PPARA Proteine) activation to drive transdifferentiation of a basal bladder cancer cells to a luminial phenotype.
Results found FOXA1 to be hypermethylated in breast tumors from African American (AA) versus European American (EA) women with ER- cancer, and methylation levels showed strong inverse relationships with both mRNA and protein levels. A significant positive association was identified between parity and FOXA1 methylation in tumors from AA women who did not breastfeed.
High expression of FOXA1 is associated with breast tumor.
High FOXA1 expression was significantly associated with presence of lymph node metastasis (LNM), low tumour-infiltrating lymphocytes (TILs), and submucosal invasion.
we propose a model in which deletion of Foxa1 from STN (zeige EEF1A2 Proteine) neurons evokes a compromised state of the STN (zeige EEF1A2 Proteine), evident by the reduced firing activity of STN (zeige EEF1A2 Proteine) neurons and the loss of a significant fraction of STN (zeige EEF1A2 Proteine) neurons.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (zeige FOXO1 Proteine) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (zeige INS Proteine)-sensitive Genes.
FoxA1, FoxA2 (zeige FOXA2 Proteine), and LIPG (zeige LIPG Proteine) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (zeige FOXP2 Proteine) Foxa1, which functions redundantly with Foxa2 (zeige FOXA2 Proteine) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (zeige LAMC1 Proteine) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (zeige LAMC1 Proteine) inhibits the transcriptional activation of Bhmt (zeige BHMT Proteine) and cystathionine gamma-lyase (zeige CTH Proteine) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (zeige HTATIP2 Proteine) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B (zeige KDM5B Proteine) was required for GATA3 (zeige GATA3 Proteine) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (zeige NANOG Proteine) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (zeige HIST3H3 Proteine).
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
, forkhead box protein A1
, hepatocyte nuclear factor 3-alpha
, transcription factor 3A
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha
, fork head domain protein 7
, HNF-3 alpha
, HNF3 alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3 alpha
, forkhead box A1
, hepatocyte nuclear factor 3-alpha-like