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rs4442975 may not confer a risk of breast cancer occurrence or progression in the Chinese Han population.
As a transcriptionally regulated program, urothelial differentiation operates as a heterarchy, wherein GATA3 (zeige GATA3 Proteine) is able to co-operate with FOXA1 to drive expression of luminal marker genes, but that P63 (zeige RPE65 Proteine) has potential to transrepress expression of the same genes.
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 (zeige IL8 Proteine) expression in ER-positive breast cancer.
Findings suggested FOXA1 may act as an anti-oncogene (zeige RAB1A Proteine) in gastric cancer (GC) cells. Low-level expression of FOXA1 protein was confirmed in GC tissues and cell lines. FOXA1 over-expression could significantly affect cell proliferation, apoptosis and tumor invasion of GC cells, which may be resulted by reversing EMT (zeige ITK Proteine).
High expression of FOXA1 is an independent prognostic parameter in ERG (zeige ERG Proteine) negative prostate cancer
A molecular mechanism by which Estradiol antagonizes GR-dependent induction of specific genes by preventing the recruitment of the pioneer factors FOXA1 and FOXA2 (zeige FOXA2 Proteine) in a physiologically relevant model.
Results show that c-Abl (zeige ABL1 Proteine) phosphorylates FoxA1 at multiple sites. Tyr429 and Tyr464 were identified as the major phosphorylation sites in the FoxA1 C-terminal region. This c-Abl (zeige ABL1 Proteine)-mediated phosphorylation of FoxA1 promotes the activation of estrogen signaling by inducing its binding to histones.
MLL3 binding was dependent on FOXA1, indicating that FOXA1 recruits MLL3 to chromatin. MLL3 silencing decreased H3K4me1 at enhancer elements but had no appreciable impact on H3K4me3 at enhancer elements. We propose a mechanism whereby the pioneer factor FOXA1 recruits the chromatin modifier MLL3 to facilitate the deposition of H3K4me1 histone marks, subsequently demarcating active enhancer elements
FoxA1 discriminates between medullary thyroid carcinoma and tumors of follicular derivation with sensitivity and specificity greater than calcitonin (zeige CALCA Proteine) and carcinoembryonic antigen (zeige CEACAM5 Proteine).
FOXA1 loss may play a significant role in enabling prostate cancer progression to neuroendocrine prostate cancer, whereas IL-8 (zeige IL8 Proteine) and MAPK/ERK (zeige MAPK1 Proteine) pathways may be promising targets for therapeutic intervention.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (zeige FOXO1 Proteine) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (zeige INS Proteine)-sensitive Genes.
FoxA1, FoxA2 (zeige FOXA2 Proteine), and LIPG (zeige LIPG Proteine) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (zeige FOXP2 Proteine) Foxa1, which functions redundantly with Foxa2 (zeige FOXA2 Proteine) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (zeige LAMC1 Proteine) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (zeige LAMC1 Proteine) inhibits the transcriptional activation of Bhmt (zeige BHMT Proteine) and cystathionine gamma-lyase (zeige CTH Proteine) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (zeige HTATIP2 Proteine) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B (zeige KDM5B Proteine) was required for GATA3 (zeige GATA3 Proteine) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (zeige NANOG Proteine) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (zeige HIST3H3 Proteine).
Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
forkhead box A1
, forkhead box protein A4
, HNF-3 alpha
, HNF3 alpha
, forkhead box protein A1
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3-alpha-like
, fork head domain protein 7
, hepatocyte nuclear factor 3-alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, transcription factor 3A
, hepatocyte nuclear factor 3 alpha
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha