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FHL2 is an important prognostic factor in cervical cancer (CC) and that it plays a crucial oncoprotein role by promoting cell proliferation and inhibiting apoptosis in CC.
FHL2 and iASPP (zeige PPP1R13L Proteine) interacted with each other and co-localized in both nucleus and cytoplasm. Either FHL2 or iASPP (zeige PPP1R13L Proteine) silenced could reduce cell proliferation, induce cell cycle arrest at G0/G1 phase, and increase cell apoptosis.
FHL2 phosphorylation by FAK (zeige PTK2 Proteine) is a critical, mechanically dependent step in signaling from soft matrices to the nucleus to inhibit cell proliferation by increasing p21 (zeige CDKN1A Proteine) expression.
FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 (zeige AKT1 Proteine) transcription.
we determined the molecular mechanism responsible for IER3 (zeige IER3 Proteine) degradation, involving a ternary complex of IER3 (zeige IER3 Proteine), MDM2 (zeige MDM2 Proteine) and FHL2, which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein
FHL2 interacts with ADAM-17 (zeige ADAM17 Proteine) in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17 (zeige ADAM17 Proteine)/FHL2 complex in the development of colorectal cancer.
FHL2 overexpression could enhance the differentiation and mineralization of human dental pulp cells
findings show that mAbp1 (zeige DBNL Proteine) and FHL2 are novel binding partners that differentially regulate Rho GTPase (zeige RACGAP1 Proteine) signaling and MTLn3 breast cancer cell invasion
These results identify FHL2 as a novel gene associated with asthma severity in human.
FHL2 might interact with Runx2 (zeige RUNX2 Proteine) to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation.
Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17 (zeige ADAM17 Proteine)-mediated release of TNF (zeige TNF Proteine)
Loss of FHL2 is associated with liver fibrosis.
loss of Fhl2 leads to an altered immune response to myocardial ischemia, which results in smaller infarcts and better hemodynamic performance up to 21 days after myocardial ischemia reperfusion.
also found that phosphorylation of ERK1/2 is markedly attenuated in FHL2-KO lung
Overexpression of FHL2 alone had no effect on Erbin (zeige ERBB2IP Proteine) expression, but in the presence of MITF (zeige MITF Proteine), Erbin (zeige ERBB2IP Proteine) expression was decreased.
these data identify a previously unrecognized role for FHL2 in the pathogenesis of pulmonary granulomatous inflammation
we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy.
FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt.
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
LIM domain protein DRAL
, aging-associated gene 11
, down-regulated in rhabdomyosarcoma LIM protein
, four and a half LIM domains protein 2
, skeletal muscle LIM-protein 3
, SLIM 3
, four and a half LIM domains 2