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Studies indicate that the T allele of SMAD7 protein (SMAD7)single nucleotide polymorphism rs4939827 to be significantly related with an increase colorectal cancer (CRC (zeige CALR Proteine)) risk in Chinese population [Meta-analysis].
this large-scale meta-analysis indicated that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) correlate with CRC (zeige CALR Proteine).
Collectively, these findings demonstrate that the miR (zeige MLXIP Proteine)-15a/Smad-7/TGF-beta (zeige TGFB1 Proteine) pathway is important in HBV-associated liver cancer.
SMAD7 promoter is hyper-methylated both in human atherosclerotic plaques and atherosclerosis patients, which is positively associated with homocysteine levels and carotid plaque scores.
Furthermore, MERS coronavirus induced apoptosis through upregulation of Smad7 and fibroblast growth factor 2 (FGF2 (zeige FGF2 Proteine)) expression in both kidney and lung cells.
findings demonstrate TGF-beta enhances expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin-mediated turnover of SMAD7; clinically, loss of USP26 correlates with high TGF-beta activity and confers poor prognosis in glioblastoma; data identify USP26 as a novel negative regulator of the TGF-beta pathway and suggest that loss of USP26 expression may be an important factor in glioblastoma pathogenesis
In conclusion, our study demonstrated that COL1A2 (zeige COL1A2 Proteine)-AS1 (zeige PTGDR Proteine)/miR (zeige MLXIP Proteine)-21/Smad (zeige SMAD1 Proteine) pathway plays an important role in inhibiting hypertrophic scar formation, and suggested this novel pathway may be a new target for hypertrophic scar treatment.
Our data revealed the SMAD7 loci is associated with hepatocellular carcinoma susceptibility and its clinicopathologic development.
Smad7 expression in necrotizing enterocolitis macrophages interrupts TGF-beta (zeige TGFB1 Proteine) signaling and promotes NF-kappaB (zeige NFKB1 Proteine)-mediated inflammatory signaling in these cells through increased expression of IKK-beta (zeige IKBKB Proteine)
SMAD7 gene and specifically the allele C could be protective for colorectal cancer (CRC (zeige CALR Proteine)). An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC (zeige CALR Proteine) risk.
lentiviral vector-mediated i.a. overexpression of Smad7 can ameliorate rheumatoid joint, implicating a pharmacological development of Smad7-based molecular strategy in collagen-induced arthritis
Smad7 expression governs splenic DC subset differentiation.
Our results indicate that miR (zeige MLXIP Proteine)-212-3p facilitates the activation of HSCs and TGF-beta (zeige TGFB1 Proteine) pathway by targeting SMAD7, highlighting that it can be served as a novel biomarker or therapeutic target for liver fibrosis.
a heterozygous deletion of SMAD7 results in an increased proliferation of Muller cell progenitors in the central retina at postnatal day 4, the time window when Muller cells differentiate in the mouse retina; this in turn results in a thickened retina and inner nuclear layer and a higher number of differentiated Muller cells in the more developed retina
changes were associated with increased expression of the antifibrotic protein Smad7 and higher levels of sphingosine in Sphk2 (zeige SPHK2 Proteine)(-/-) unilateral ureteral obstruction kidneys
Smad7 plays a protective role in acute kidney injury by preventing tubular epithelial cells from the G1 cell cycle arrest.
study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta (zeige TGFB1 Proteine) and CLIC4 (zeige CLIC4 Proteine), is a dominant inhibitor of Smad7 and enhances TGF-beta (zeige TGFB1 Proteine) signaling
Pancreatic depletion of SMAD7 resulted in age-dependent increases in beta cell dysfunction with accelerated glucose intolerance, followed by overt diabetes.
The inverse correlation between Smad7 and AhR (zeige AHR Proteine) expression helps to propagate inflammatory signals in the gut (zeige GUSB Proteine) in Crohn's disease.
results indicate that miR (zeige MLXIP Proteine)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) and Wnt (zeige WNT2 Proteine) signaling pathway by directly targeting Smad7 and Tcf7l2 (zeige TCF7L2 Proteine)
Tril (zeige TRIL Proteine) is a novel component of a Bmp-Gata2 (zeige GATA2 Proteine) positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
cTid1 can bind to other members of the Smad (zeige SMAD1 Proteine) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (zeige SCN4A Proteine) domain
Smad7 has a role in Xenopus mesodermal and neural induction
SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.
MiR (zeige MYLIP Proteine)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7.
Results suggest that myostatin (zeige MSTN Proteine) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
MAD (mothers against decapentaplegic, Drosophila) homolog 7
, MAD homolog 8
, Mothers against decapentaplegic, drosophila, homolog of, 7
, SMAD, mothers against DPP homolog 7
, mothers against DPP homolog 8
, mothers against decapentaplegic homolog 7
, MAD homolog 7
, SMAD 7
, mothers against DPP homolog 7
, mothers against decapentaplegic homolog 8
, MAD, mothers against decapentaplegic homolog 7
, mothers against DPP 7
, mothers against decapentaplegic-like protein 7
, SMAD family member 7