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Findings unveil a negative role for PKC-delta in cell-cell adhesion through phosphorylation of E-cadherin (zeige CDH1 Proteine).
ADP inhibits mesothelioma cell proliferation via PKC-delta/JNK (zeige MAPK8 Proteine)/p21 (zeige CDKN1A Proteine)/p27 (zeige PAK2 Proteine) signaling.
PKCdelta, via MAPK (zeige MAPK1 Proteine) pathway, is involved in the glycodelin (zeige PAEP Proteine)-driven cell differentiation.
PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha (zeige TNF Proteine)-activated endothelium, and reduced expression of E-selectin (zeige SELE Proteine) and ICAM-1 (zeige ICAM1 Proteine). Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (zeige HCK Proteine)-dependent activation of PKCdelta, which stimulates PKCgamma (zeige PRKCG Proteine), resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor (zeige PGR Proteine) and PRKCA (zeige PKCa Proteine)-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin (zeige AREG Proteine) enhances VEGF-A (zeige VEGFA Proteine) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (zeige MLXIP Proteine)-206 via FAK (zeige PTK2 Proteine)/c-Src (zeige SRC Proteine)/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR (zeige MLXIP Proteine)-486 may be a potential target for the treatment of osteosarcoma
PKCdelta and PKCepsilon (zeige PRKCE Proteine) work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
These findings suggest that targeting Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) or Akt (zeige AKT1 Proteine) pathways may increase the efficacy of taxane chemotherapy in advanced human prostate cancers that have lost PKCdelta expression.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP (zeige TIRAP Proteine)-p38 (zeige CRK Proteine)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD (zeige SCD Proteine), which may become a potential target for pharmacological interventions
K8/K18 (zeige KRT18 Proteine)-dependent PKCdelta- and ASMase (zeige SMPD1 Proteine)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 Proteine) loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (zeige SRSF2 Proteine)) to promote alternative splicing of PKCdeltaII.
SphK1 (zeige SPHK1 Proteine) dependent PKC-delta activation plays an important role in promoting NF-kappaB (zeige NFKB1 Proteine) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT (zeige SLC1A3 Proteine) translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC (zeige POMC Proteine) and ACTH (zeige POMC Proteine) expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
PKCdelta-mediated phosphorylation of 14-3-3zeta (zeige YWHAZ Proteine) contributes to the nuclear retention of FOXO1 (zeige FOXO1 Proteine), even when FOXO1 (zeige FOXO1 Proteine) is phosphorylated as under non-stress conditions
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (zeige FGF2 Proteine)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (zeige FGF2 Proteine) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (zeige NOS3 Proteine) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (zeige CDK7 Proteine) Cdelta-dependent phosphorylation of syndecan-4 (zeige SDC4 Proteine) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (zeige NFE2L2 Proteine) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (zeige PRKCG Proteine) mediates the apoptotic processes through ROS (zeige ROS1 Proteine)-dependent caspase-3 (zeige CASP3 Proteine) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta