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NSC606985 produced a dose-dependent subcellular activation of PKCdelta. The dose-dependent dual action of NSC is mediated at least in part through the differential subcellular activation of castration-resistant prostate cancer (CRPC) LAPC4 cells.
PKC-delta expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta may be a potential therapeutic target for AdCCs.
Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
PKC-delta played as a protective role in squamous cell carcinomas partly by down-regulating p63 (zeige RPE65 Proteine), leading to the suppression of squamous cell carcinomas cell proliferation
Activated PKCdelta interacts with the polymerase subunit PB2 and phospho-regulates NP oligomerization and RNP (zeige RNPC3 Proteine) assembly during Influenza A virus infection.
NRF2 (zeige GABPA Proteine) Ser40 phosphorylation was inhibited in Crif1 (zeige GADD45GIP1 Proteine)-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC (zeige PRRT2 Proteine) agonists, suggesting that CRIF1 (zeige GADD45GIP1 Proteine) might co-activate PKC-delta to phosphorylate NRF2 (zeige GABPA Proteine) Ser40.
PKCdelta has an overall negative influence on platelet function in response to collagen, while, following PAR (zeige JTB Proteine) stimulation, PKCdelta has a positive effect on platelet function. PKCdelta has different roles in platelet activation, aggregation and thrombus formation. Review.
Findings unveil a negative role for PKC-delta in cell-cell adhesion through phosphorylation of E-cadherin (zeige CDH1 Proteine).
ADP inhibits mesothelioma cell proliferation via PKC-delta/JNK (zeige MAPK8 Proteine)/p21 (zeige CDKN1A Proteine)/p27 (zeige PAK2 Proteine) signaling.
PKCdelta, via MAPK (zeige MAPK1 Proteine) pathway, is involved in the glycodelin (zeige PAEP Proteine)-driven cell differentiation.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP (zeige TIRAP Proteine)-p38 (zeige CRK Proteine)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD (zeige SCD Proteine), which may become a potential target for pharmacological interventions
K8/K18 (zeige KRT18 Proteine)-dependent PKCdelta- and ASMase (zeige SMPD1 Proteine)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 Proteine) loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (zeige SRSF2 Proteine)) to promote alternative splicing of PKCdeltaII.
SphK1 (zeige SPHK1 Proteine) dependent PKC-delta activation plays an important role in promoting NF-kappaB (zeige NFKB1 Proteine) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT (zeige SLC1A3 Proteine) translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC (zeige POMC Proteine) and ACTH (zeige POMC Proteine) expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (zeige FGF2 Proteine)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (zeige FGF2 Proteine) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (zeige NOS3 Proteine) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (zeige CDK7 Proteine) Cdelta-dependent phosphorylation of syndecan-4 (zeige SDC4 Proteine) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (zeige NFE2L2 Proteine) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (zeige PRKCG Proteine) mediates the apoptotic processes through ROS (zeige ROS1 Proteine)-dependent caspase-3 (zeige CASP3 Proteine) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta