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Human IRF1 Protein expressed in Wheat germ - ABIN1308073
Liu, Khachigian et al.: Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and ... in The Journal of biological chemistry 2009
Following spring viremia of carp (zeige ANKRD1 Proteine) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (zeige ANKRD1 Proteine) virus. data provide evidence that fish and mammals have evolved a similar IRF (zeige TRIM63 Proteine)-dependent regulatory mechanism fine-tuning IFN gene activation.
Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 (zeige FOXP3 Proteine) and KLF-10 and downregulation of IRF-1.
As a measure of PD-L1 (zeige CD274 Proteine) expression capability, IRF-1 expression may be a more valuable predictive biomarker for anti-PD-1 (zeige PDCD1 Proteine) therapy than PD-L1 (zeige CD274 Proteine) itself.
Upregulation of IRF1 in human adipocytes leads to phenotypes associated with obesity-related inflammation.
Regulation of transcriptional activators by DNA-binding domain (DBD) ubiquitination has shown that, when attached to the DBD of either p53 or IRF-1, ubiquitin is orientated towards, and makes contact with, the DNA.
In SK-Hep1 cells, an increase in apoptosis and decrease in autophagy were observed after IFN-gamma (zeige IFNG Proteine) stimulation, which was accompanied with increasing IRF-1 levels.
HNP1 (zeige DEFA1 Proteine) upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (zeige NFKB1 Proteine) activation or knockdown of IRF1, demonstrating the importance of these two signaling events in HNP1 (zeige DEFA1 Proteine)-induced pDC (zeige PNKD Proteine) activation.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (zeige MLXIP Proteine)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (zeige SOCS5 Proteine)).
A comprehensive mass spectrometric analysis identified interferon regulatory factor 1 (IRF1) as a key transcription factor in growth arrest of LNCaP-mTOR (zeige FRAP1 Proteine).
IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) pathway
B. abortus lipoproteins via IL-6 (zeige IL6 Proteine) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (zeige CIITA Proteine) induction.
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 plays a key role in controlling caspase-1 (zeige CASP1 Proteine)-dependent pyroptosis and inflammation.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (zeige HCFC2 Proteine) is a critical component of the IRF1 and IRF2 (zeige IRF2 Proteine) transcriptional machinery that regulates Tlr3 (zeige TLR3 Proteine) gene expression.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 (zeige TXNRD1 Proteine) gene network in response to IL-27 (zeige IL27 Proteine) signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 (zeige TXNRD1 Proteine) lineage.
IRF-1 and interferon-alpha (zeige IFNA Proteine) with interferon-beta (zeige IFNB1 Proteine) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (zeige STAT1 Proteine) and IRF1 are associated with robust and IL-4 (zeige IL4 Proteine)-resistant responses to IFN-gamma (zeige IFNG Proteine) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (zeige IRF8 Proteine)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (zeige MLXIP Proteine)-342-5p to the antiviral interferon (zeige IFNA Proteine) response
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1