anti-Human IRF1 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended IRF1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 1 (IRF1) Antikörper
  • irf1
  • zgc:136945
  • IRF1
  • irf11
  • zgc:103566
  • IRF-1
  • MAR
  • AU020929
  • Irf-1
  • interferon regulatory factor 1
  • interferon regulatory factor 1a
  • interferon regulatory factor 1b
  • IRF1
  • irf1a
  • irf1b
  • Irf1
Reaktivität
Human, Maus
112
57
27
11
11
11
9
9
8
6
5
1
1
1
Wirt
Kaninchen
117
21
2
1
Klonalität
Monoklonal
Konjugat
Dieser IRF1 Antikörper ist unkonjugiert
8
8
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
129
47
27
17
11
9
7
6
4
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN5557374
$ 402.49
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN3042646 ICC IHC (p) WB Rabbit IgG AA 169-183, Middle Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN2624261 ICC IHC IHC (p) WB Rabbit IgG AA 169-183 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5947983 FACS ICC IF IHC IHC (p) IP WB Rabbit IgG C-Term Anmelden zum Anzeigen SR44-08 0
1 ABIN3031414 ICC IHC (p) WB Rabbit IgG Middle Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN5560656 IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 1 (IRF1) Antikörper
Reaktivität Human, Maus
(112), (57), (27), (11), (11), (11), (9), (9), (8), (6), (5), (1), (1), (1)
Wirt Kaninchen
(117), (21), (2), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IRF1 Antikörper ist unkonjugiert
(8), (8), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(129), (47), (27), (17), (11), (9), (7), (6), (4), (3), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IRF1 Antikörper

Target Details IRF1 Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen Recombinant human IRF1 protein, around C-terminal 100aa.
Klon 3G7
Isotyp IgG
Plasmids, Primers & others

Target Details IRF1

Produktdetails anti-IRF1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IRF1 (IRF1 Antibody Abstract)
Hintergrund

Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin, antibacterial response, such as NOS2/INOS, anti-proliferative response, such as p53/TP53, LOX and CDKN1A, apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8, immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB, DNA damage responses and DNA repair, such as POLQ/POLH, MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.

Synonyms: Interferon regulatory factor 1, IRF1

Gen-ID 3659
UniProt P10914
Pathways Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagie

Anwendungsinformationen

Produktdetails anti-IRF1 Antikörper Target Details IRF1 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:1000-2000
IHC-P 1:50-200
IF(ICC) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IRF1 Antikörper Target Details IRF1 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-IRF1 Antikörper Target Details IRF1 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Interferon Regulatory Factor 1 (IRF1) antibody (ABIN5557374) Lane 1: PC-12 Cell lysates, Lane 2: Jurkat Cell lysates, probed with IRF1 (3G7) Monoc...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Interferon Regulatory Factor 1 (IRF1) antibody (ABIN5557374) HeLa cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS a...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interferon Regulatory Factor 1 (IRF1) antibody (ABIN5557374) Paraformaldehyde-fixed, paraffin embedded Mouse brain, Antigen retrieval by boiling i...