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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
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Rat (Rattus) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305089
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN935524
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN804259
Apte, Baz, Groves, Kelso, Kienzle: Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
Human IFNG Protein expressed in HEK-293 Cells - ABIN2181249
Derynck, Leung, Gray, Goeddel: Human interferon gamma is encoded by a single class of mRNA. in Nucleic acids research 1982
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IL-15 (zeige IL15 Proteine) induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 (zeige IL15 Proteine) is associated with the development of important side effects mainly mediated by IFN-gamma-producing T-cells
Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited.
these findings highlight critical roles for IFN-gamma and IL-27 (zeige IL27 Proteine) in the mechanism of respiratory syncytial virus-induced exacerbation
MyD88 (zeige MYD88 Proteine) signaling in myeloid and dendritic cells is dispensable for IFN-gamma-dependent control of type A F. tularensis infection.
spleen-derived IFN-gamma induces generation of PD-L1 (zeige CD274 Proteine)(+)-suppressive neutrophils.
These results suggest that IL-17A (zeige IL17A Proteine) plays an important role in host survival against Toxoplasma gondii infection by protecting the host from an anaphylactic reaction via the downregulation of Toxoplasma gondii HSP70 (zeige HSP70 Proteine) and IFN-gamma production.
Stat3 (zeige STAT3 Proteine) mediates the expression of iNOS (zeige NOS2 Proteine) to promote IFNgamma/TNFalpha (zeige TNF Proteine)-induced muscle atrophy.
NFAT5 (zeige NFAT5 Proteine) can modulate different T-cell responses depending on stress conditions and stimulatory context.
we identify interferon-gamma (IFN-gamma) as the key inflammatory mediator controlling sortilin-1 (zeige SORT1 Proteine) levels
this study shows that IFN-gamma induction by neutrophil-derived IL-17A (zeige IL17A Proteine) homodimer augments pulmonary antibacterial defense
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 (zeige IL4 Proteine) ratio were significantly lower than those exposed to its low concentration.
Results showed that IFNG upregulated PD-L1 (zeige CD274 Proteine) expression in gastric cancer cells mainly through JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) pathway.
The findings suggest that not the IFN-gamma (+874) A/T but the IL-12 (zeige IL12A Proteine) (-1188) A/C polymorphism is correlated with subacute sclerosing panencephalitis (SSPE), and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.
This review focuses on the immune modulatory functions of IFN-gamma in cancer.
Cytokines (IFNg and IL-4 (zeige IL4 Proteine)) estimation was done in the blood and NPA samples of cases and blood samples of controls.The mean levels of interleukin-4 (zeige IL4 Proteine) in controls (blood), and cases (NPA and blood) were 1280.77, 956.08 and 692.37 pg/ml, respectively (P<0.05).
Severe gastroenteritis and acute pancreatitis following rotavirus infection in children: The age-related failure of IFN-gamma.
Our observations suggested that IL-10 (zeige IL10 Proteine) -592 A/C, -1082 G/A, and IFN-gamma +874 T/A polymorphisms had a strong association with susceptibility to HCV infection. However, no significant association was observed between the cytokines (IL-10 (zeige IL10 Proteine) and IFN-gamma) genotypes profile and HCV-liver cirrhosis risk in the studied population, except for the high frequency of IFN-gamma +874 T allele in cirrhotic patients.
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha) positively regulated RIG-I; with PRMT-1 and G9a affecting PGC-1alpha in a counter-regulatory manner.
Results showed that plasma and mRNA levels of IL-2 (zeige IL2 Proteine), IFN-gamma, IL-4 (zeige IL4 Proteine), and IL-17A (zeige IL17A Proteine) in primary immune thrombocytopenia patients did not change significantly after TPO (zeige THPO Proteine)-RA treatment, whereas TGF-beta1 (zeige TGFB1 Proteine) levels increased remarkably.
These findings demonstrate how IFNgamma induced CK2 (zeige CSNK2A1 Proteine) regulates RIG-I (zeige DDX58 Proteine) to drive a complex program of metabolic adaptation and redox homeostasis, crucial for determining glioma cell fate.
Data indicate that dysregulated IFN-gamma secretion by NK cells contributed to a significant defect in STAT1 (zeige STAT1 Proteine) in patients with advanced melanoma in response to IL-2 (zeige IL2 Proteine) stimulation.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR (zeige NR1I2 Proteine).
Translational control of IL-18 (zeige IL18 Proteine) expression by its 5'-UTR limits production of IL-18 (zeige IL18 Proteine), resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8 (zeige CD8A Proteine)+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
The expression of multiple toll (zeige TLR4 Proteine)-like receptors, interferon-gamma, and interleukin-12 (IL-12 (zeige IL12A Proteine)) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha (zeige TNF Proteine), and PGF2a) control expression of MMP1 (zeige MMP1 Proteine), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 (zeige IL4 Proteine) production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 (zeige IFNGR1 Proteine) and R2, IL22 (zeige IL22 Proteine), and IL22RA1 (zeige IL22RA1 Proteine) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
These results indicate that in equine corpus luteum, cytokines TNF (zeige TNF Proteine), IFNG and FASL (zeige FASL Proteine) regulate nitric oxide activity, via eNOS (zeige NOS3 Proteine) expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation (zeige HELLS Proteine) in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation (zeige FAS Proteine).
These data show the presence of cytokines TNF (zeige TNF Proteine) and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 (zeige IL10 Proteine) production by T cells is mature.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1 (zeige TGFB1 Proteine).
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
CD3 (zeige CD3 Proteine)(-) CD8 (zeige CD8A Proteine)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 (zeige IL15 Proteine) elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15 (zeige IL15 Proteine), CD8 (zeige CD8A Proteine) antigen, IFN-gamma]
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, gamma interferon
, interferon, gamma
, interferon gamma
, immune interferon
, interferon gamma type 2
, Interferon gamma
, IFN gamma