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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
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Rat (Rattus) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305089
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
Show all 2 Pubmed References
Mouse (Murine) IFNG Protein expressed in - ABIN1111688
Aittaleb, Chen, Akaaboune: Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn. in Journal of cell science 2016
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN2129887
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN804259
Apte, Baz, Groves, Kelso, Kienzle: Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
Low IFNG expression is associated with Colorectal Cancer.
berrant histone methylation of IFN-gamma associating H3K4me3 and H3K27me3 caused by over-binding of Ash2L and Jmjd3 might be involved in immune dysfunction and vascular damage in Kawasaki disease in the acute phase.
Taken together, the pro-inflammatory cytokines TNF-alpha and IFN-gamma seem to play a special role in the human endometrium, as the combination of both not only sensitizes ESCs human endometrial stromal cells] to Fas-mediated apoptosis, but also strongly stimulates chemoattractant molecules.
The rs2069705 polymorphism was significantly associated with severity in Colombian dengue hemorrhagic fever patients.
findings provide evidence for crosstalk between JAK2-STAT1 and PI3K-AKT pathways in response to IFN-gamma in lung adenocarcinoma and have implications for the design of combinatorial targeted therapy and immunotherapy for the treatment of lung adenocarcinoma
Alterations of the IL-7/IL-7R axis and in the levels of inflammatory cytokines were linked to impaired T. cruzi-specific IFN-gamma production.
In active human systemic lupus erythematosus, MMP12 levels were lower and IFN-gamma higher compared to treated patients or healthy individuals. Hence, macrophage proteolytic truncation of IFN-gamma attenuates classical activation of macrophages as a prelude for resolving inflammation.
An association between two SNPs and acute radiation skin reactions (ARSR) was found in XRCC2 and IFNG. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation.
these findings demonstrated a more powerful prediction of early acute renal allograft rejection during the first month after transplantation by combination of multiple-biomarkers of fractalkine, IFN-gamma and IP-10, and the results might help stratify the immunologic risk of acute allograft rejection in recipients
IFN-gamma and IL-17 from CD4+T cells play a crucial role in guttate psoriasis, however, IFN-gamma and IL-17 from CD8+T cells are more important in the immunopathogenesis of plaque psoriasis.
Impaired IFNgamma-Signaling and Mycobacterial Clearance in IFNgammaR1-Deficient Human iPSC-Derived Macrophages.
High expression of IFNG is associated with breast cancer.
results suggest, the interplay of pro-inflammatory cytokines IFN-gamma derived from CD4+T lymphocytes and TNF-alpha from CD14+ cells has no direct additive impact on parasite replication but induces IL-4 production.
IFN-lambda may participate in local inflammation in the salivary glands of primary Sjogren's syndrome patients through direct and indirect regulations of the expressions of BAFF and CXCL10 in salivary gland epithelium.
The expression of CXCL10 mRNA and IFN-gamma mRNA was significantly higher in non-lesional and perilesional skin of vitiligo and alopecia areata patients compared with the skin of healthy controls; however, the level of expression of CXCL10 and IFN-gamma in lesional skin was not different than that in healthy skin
High IFNG expression is associated with Chronic Periodontitis.
hypomethylation of the IFNG promoter is significantly related to the risk of essential hypertension
These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 in human BM and WJMSCs were mediated by STAT1 signaling, and not by PI3K/RACalpha serine/threonineprotein kinase signaling
serum IP-10 level and the IFN-gamma/IL-4 ratio have great potential to predict significant fibrosis among chronic hepatitis B patients.
IFN-gamma increases free ISG15 levels in the cytoplasm and ISGylation in the nucleus and cytoplasm, but in a manner distinct between MCF-7 and MDA-MB-231cells.
gammadelta T-cell production of IL-21 and IFN-gamma is crucial for the development and maintenance of follicular helper T cells and germinal centre B cells during the late phase of infection.
Proliferation/survival and cytokine production of kidney-residing Innate lymphoid cells was suppressed by IFN-gamma and, to a lesser extent, by IL-27 which were produced by activated T cells and myeloid cells in the nephritic kidney, respectively.
Here we reveal a distinct role of IFNgamma for the development of intestinal inflammation in two different mouse models of colitis in the same mouse strain with the same microbial composition.
Gal-3 acts directly on B cells to regulate germinal centers responses via IFN-gamma.
In addition to highlighting the importance of TNF in CD8(+) T cell- and NK cell-mediated killing of tumor cells, our study also provides a comprehensive picture of the roles of the TNF, IFN, and antigen presentation pathways in immune-mediated tumor surveillance.
Data show that interleukin-2 inducible T cell kinase (Itk)negatively regulates the development of nTh1 cells that express interferon-gamma (IFNgamma) in a T-bet transcription factor (Tbet) independent manner.
demonstrate in vivo that the conditional overexpression of Ifng in metanephric mesenchymal (MM) progenitors results in renal agenesis or hypoplasia. Cell death was observed in and around the MM region of E10.5-11.5 mutants where Ifng was constitutively expressed during early kidney development and resulted in retardation of branching morphogenesis. Expression of Sall1 was decreased in the MM of mutant kidneys.
Data confirm Ifng as robust supporter of immune responses against tumors; here, mice treated with Chlorella vulgaris probiotic supposed as anti-carcinogen against mammary tumor, instead tumors in treated group exhibit more malignant phenotype and lower peri-tumoral neutrophil and macrophage-to-lymphocyte infiltration ratio compared to control mice; decline in serum Ifng levels correlated with tumor growth.
In interferon gamma (IFNgamma)-deficient mice, Akkermansia muciniphila is significantly increased and restoration of IFNgamma levels reduces A. muciniphila abundance.
this study shows the positive effects of Ifng on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro
these data support the novel concept that IFN-gamma can have a detrimental role in the pathogenesis of influenza through a restriction in innate lymphoid cell group II activity
IFN-gamma-iNOS axis are an essential pathway in the pathogenesis of arenavirus hemorrhagic fever.
IFN-gamma can promote cancer immunoevasion. (Review)
Study shows that circulating interferon- that binds to receptors on brain endothelial cells and induces Cxcl10, is a central link in the signaling chain eliciting inflammation-induced aversion.
IRF-1 may be at the nexus of the interplay between IFN-gamma and IL-6 in exacerbating a xenobiotic-induced inflammatory response, regulation of interferon responsive genes and autoimmunity
an enhanced expression of PD-L1 was observed besides an increased production of IFN-gamma by TH2 cells.
The opposing roles of G-CSF and IFNgamma in regulation of innate inflammatory responses in a murine viral encephalitis model reveal G-CSF as a potential therapeutic target.
Phosphorylation of T-bet by RSK2 is required for IFNgamma expression for attenuation of colon cancer metastasis and growth.
SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes.
The complex role of IFN-gamma in autoimmunity and cholangitis.IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR.
Mapping of QTL for mycoplasma and tetanus antibodies and IFNgamma.
Data show taht the expression of PoIFN-gamma in insect cells was confirmed by Western Blot, indirect immunofluorescence assay and indirect ELISA.
IFNgamma production from the frozen peripheral blood mononuclear cells was significantly higher than that from the fresh ones.
Translational control of IL-18 expression by its 5'-UTR limits production of IL-18, resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
CD3(-) CD8(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 antigen, IFN-gamma]
Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-gamma production via PD-1/PD-L1 blockade in bovine mycoplasmosis.
The expression of multiple toll-like receptors, interferon-gamma, and interleukin-12 (IL-12) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
Data demonstrated that the monoclonal antibodies secreted by the four hybridoma cell lines could react specifically to the recombinant BovIFN-gamma.
The entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced. A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae.
Bovine interferon gamma demonstrates no effect on P-glycoprotein transport activity in human Caco-2 intestinal epithelial cells with rhodamine 123 as susbstrate.
In giant cell arteritis, IFN-gamma functional polymorphisms are associated with clinical manifestations of severity rather than susceptibility to this vasculitis.
The majority of patients with gad-enhancing lesions showed PLP/IFN gamma and MBP/IFN gamma recurrent burst responses
A polymorphism within the interferon gamma gene is a risk factor in severe acute respiratory syndrome susceptibility.
Intradermal sensitization of cows in the subclinical stage of M. paratuberculosis infection will upregulate expression of interferon gamma, enhancing the sensitivity of this assay.
This study compared the protective immune responses to bovine tuberculosis induced in cattle vaccinated with BCG Danish with those induced by BCG Pasteur.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation.
These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1.
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
The zfIFN-gamma monoclonal antibody specifically recognises E. coli produced recombinant IFN-gamma protein and zfIFN-gamma produced in transfected HEK293 cells, by Western blot analysis. IFN-gamma protein is produced as a dimer, and a good correlation exists between transcript expression levels and protein levels.
There are two IFN-gamma-like genes are present in tandem, 7.0 kb apart from each other, in the zebrafish genome.
IFN-gamma signaling acts cell autonomously to control the endothelial-to-hematopoietic stem cell transition
These results support a central role of IFNgamma in mediating biliary defects in developing vertebrates, and further support a role for IFNgamma in the pathogenesis of disorders such as biliary atresia.
These data throw light on partially redundant functions of fish IFNgamma genes.
Conditions are identified in which Ifn-gamma1 and Ifn-gamma2 are induced in fish larvae and adults; the receptor complex for Ifn-gamma2 includes cytokine receptor family B (Crfb)6 together with Crfb13 and Crfb17.
zebrafish IFN-gamma1 and IFN-gamma2 are functionally equivalent to mammalian IFN-gamma
Evidence is provided for a pivotal role of group II interferon of zebrafish in the early stages of viral infections, whereas group I interferons exert a slow but more powerful induction of several antiviral and proinflammatory genes.
the identification of a novel isoform of the zebrafish (Danio rerio) IFNGR1 is reported.
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, immune interferon
, interferon gamma
, gamma interferon
, IFN gamma
, interferon gamma type 2
, interferon, gamma
, Interferon gamma
, interferon alpha