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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
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Human IFNG Protein expressed in HEK-293 Cells - ABIN2181249
Derynck, Leung, Gray, Goeddel: Human interferon gamma is encoded by a single class of mRNA. in Nucleic acids research 1982
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Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305090
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
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Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN2129887
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Human IFNG Protein expressed in CHO Cells - ABIN2648879
Razaghi, Villacrés, Jung, Mashkour, Butler, Owens, Heimann: Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells. in Experimental cell research 2017
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN804259
Apte, Baz, Groves, Kelso, Kienzle: Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
Serum levels of IL-10 and IFNgamma increased significantly in the group of allergic asthmatic patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly.
IFN-gamma in peripheral hematopoietic stem cells/leukapheresis product seems to be an important biomarker of loss of response in multiple myeloma, suggesting a role in early post-transplant therapeutic management.
polymorphisms of gamma-interferon affect disease severity in children infected with herpesvirus type 6
The co-expression of IFN-gamma and IL-10 in bone marrow derived mesenchymal stem cells inhibits HCC in vitro and in vivo by modulating cell cycle regulators and MAPK pathway.
an expression quantitative trait loci of the ZXDC gene is associated with IFN-gamma production following Mycobacterium tuberculosis antigen-specific stimulation.
These data shows potential interaction between IFN-gamma and TLR2 responses in human periodontal ligament stem cells.
Interferon-stimulated gene expression and associated innate signaling mechanisms during Mycobacteria Infection in macrophages was studied.
vitamin D suppresses lipopolysaccharide-induced HIF-1alpha to block IFNgamma and IL-1beta productions.
Interferon-gamma blood level is associated with tuberculosis in the HIV infected patients.
high serum IFN-gamma levels as a potent biomarker for predicting mesenchymal stem cell transplantation response.
This meta-analysis concluded that IFN-gamma +874 A > T gene polymorphism is meaningfully related with the reduced extrapulmonary tuberculosis risk in overall and Asian population, and further necessitates larger studies to be conducted on this topic in other races.
During severe sepsis, intense on-going mtDNA damage and mitochondrial dysfunction could overwhelm the capacity for mitochondrial biogenesis, leading to a gradual decline in mtDNA levels over time. Our data suggest that this may contribute to monocyte immune deactivation, which is associated with adverse clinical outcomes and could be reversed by IFN-gamma.
This study was performed to assess potential association of autoimmune hepatitis with interferon-gamma gene single nucleotide polymorphisms
IFN-gamma promoted expression of anti-pathogenic proteins and induced mesenchymal stem cells to limit inflammation and fibrosis while promoting their own survival.
cytokines up-regulate CX3CR1 expression on human monocytes by different intracellular mechanisms.
BANCR expression induced by IFN-gamma was suppressed when STAT1 phosphorylation was blocked by JAK inhibitor 1.
higher concentrations of nitric oxide and lower levels of TNF-alpha were observed in the amniotic fluid than in the serum of acute pregnancies, while TGF-beta e INF-gamma levels were similar in both biological material.
The aim of the study was to correlate the effects of host cytokine single nucleotide polymorphisms of TNF-alpha (-308 A/G) and IFN-gamma (+874 A/T) in spontaneous or IFN induced treatment response in the hepatitis c cvirus infected thalassemic individuals.
It could be suggested that heritage of AT genotype at position +874 of IFN-gamma may predispose and TT genotype can resist individual to visceral leishmaniasis in an endemic area in the southwest of Iran.
The levels of IL-32, IL-1, and IFN-gamma protein and transcripts in serum and PBMCs from hepatitis B patients were higher than those in healthy volunteers.
This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions.
results therefore indicate that IFN-gamma production by NK cells plays an important role in activating and enhancing innate and adaptive immune responses at early stages of pulmonary pulmonary nontuberculous mycobacteria infections.
these results demonstrated that an increased TLR4 expression in CD38(-/-) mice could contribute to the aggravation of acute kidney injury through boosting of the production of IFN-gamma
Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-gamma and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6.NOD-Aec1Aec2 mice. There were elevated frequencies of IFN-gamma and IL-17A-producing effector T cell populations in female SjS(S) mice compared to male SjS(S) mice.
Results suggest that altered interferon gamma (IFN-gamma) levels could be used as peripheral biomarker of cognitive deficit and treatment response.
These results suggest that IFN-gamma in the lesional skin may reduce ceramides with long-chain fatty acids by decreasing the expression of fatty acid elongases. IFN-gamma may contribute to the chronicity of atopic dermatitis by impairing barrier function.
FAT10 fine-tunes the balance of interferons during viral infection by lowering the production of type I and enhancing type II interferons.
IFN-gamma-/- mice showed exacerbation of cartilage damage, increased Th17 cell number and upregulated IL-17 and TNF-alpha expression.
Paracrine co-stimulation of IFN-gamma signaling by integrins modulates CD8 T cell differentiation.
The blockade of inhibitory receptor PD-1 stimulated the production of IFNG in chronic T cells, but failed to shift their metabolism towards aerobic glycolysis, as observed in effector T cells.
gammadelta T cells are detected at spinal cord injury lesion sites within 24 hours after injury and are predominantly of the Vgamma4 subtype and express the inflammatory cytokine IFN-gamma. Inactivating IFN-gamma signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid and improves functional recovery.
These data suggest that myeloid cell-derived Wnt ligands drive early Wnt/beta-catenin signaling that curbs IFN-gamma responses, but that, subsequently, Wnt ligands sustain IFN-gamma expression independent of beta-catenin activity.
T-bet is the key initiator and mediator of anti-islet allogeneic responses through the induction of potent Th1 inflammatory and cytotoxic responses that can act in an IFNgamma-dependent or -independent manner.
These findings suggest that pyrilamine, diphenhydramine, JNJ7777120, and thioperamide can suppress IFN-gamma production in activated splenocytes in a histamine-independent manner.
The present findings showed that IFN-gamma had an inhibitory effect on Listeria monocytogenes-induced apoptosis of neutrophils. IFN-gamma is rapidly produced and plays a critical protective role against Listeria monocytogenes infection.
IFN-gamma inhibited IL-10 production induced by TLR2, TLR3, TLR4 and TLR7/8 agonists, but stimulated IL-10 production when cells were triggered with CpG oligodeoxynucleotides, a specific TLR9 agonist. The stimulatory effect of IFN-gamma on TLR9-induced IL-10 was restricted to B cells.
Viral infection causes short-term systemic insulin resistance (IR). Virally-induced interferon-gamma (IFN-gamma) directly targets skeletal muscle to downregulate the insulin receptor but does not cause loss of glycemic control because of a compensatory increase of insulin production. Hyperinsulinemia enhances antiviral immunity through direct stimulation of CD8(+) effector T cell function.
gammadelta T-cell production of IL-21 and IFN-gamma is crucial for the development and maintenance of follicular helper T cells and germinal centre B cells during the late phase of infection.
Proliferation/survival and cytokine production of kidney-residing Innate lymphoid cells was suppressed by IFN-gamma and, to a lesser extent, by IL-27 which were produced by activated T cells and myeloid cells in the nephritic kidney, respectively.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR.
Mapping of QTL for mycoplasma and tetanus antibodies and IFNgamma.
Data show taht the expression of PoIFN-gamma in insect cells was confirmed by Western Blot, indirect immunofluorescence assay and indirect ELISA.
IFNgamma production from the frozen peripheral blood mononuclear cells was significantly higher than that from the fresh ones.
Translational control of IL-18 expression by its 5'-UTR limits production of IL-18, resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
CD3(-) CD8(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 antigen, IFN-gamma]
Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-gamma production via PD-1/PD-L1 blockade in bovine mycoplasmosis.
The expression of multiple toll-like receptors, interferon-gamma, and interleukin-12 (IL-12) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
Data demonstrated that the monoclonal antibodies secreted by the four hybridoma cell lines could react specifically to the recombinant BovIFN-gamma.
The entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced. A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae.
Bovine interferon gamma demonstrates no effect on P-glycoprotein transport activity in human Caco-2 intestinal epithelial cells with rhodamine 123 as susbstrate.
In giant cell arteritis, IFN-gamma functional polymorphisms are associated with clinical manifestations of severity rather than susceptibility to this vasculitis.
The majority of patients with gad-enhancing lesions showed PLP/IFN gamma and MBP/IFN gamma recurrent burst responses
A polymorphism within the interferon gamma gene is a risk factor in severe acute respiratory syndrome susceptibility.
Intradermal sensitization of cows in the subclinical stage of M. paratuberculosis infection will upregulate expression of interferon gamma, enhancing the sensitivity of this assay.
This study compared the protective immune responses to bovine tuberculosis induced in cattle vaccinated with BCG Danish with those induced by BCG Pasteur.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG and FASL regulate nitric oxide activity, via eNOS expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation.
These data show the presence of cytokines TNF and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1.
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
The zfIFN-gamma monoclonal antibody specifically recognises E. coli produced recombinant IFN-gamma protein and zfIFN-gamma produced in transfected HEK293 cells, by Western blot analysis. IFN-gamma protein is produced as a dimer, and a good correlation exists between transcript expression levels and protein levels.
There are two IFN-gamma-like genes are present in tandem, 7.0 kb apart from each other, in the zebrafish genome.
IFN-gamma signaling acts cell autonomously to control the endothelial-to-hematopoietic stem cell transition
These results support a central role of IFNgamma in mediating biliary defects in developing vertebrates, and further support a role for IFNgamma in the pathogenesis of disorders such as biliary atresia.
These data throw light on partially redundant functions of fish IFNgamma genes.
Conditions are identified in which Ifn-gamma1 and Ifn-gamma2 are induced in fish larvae and adults; the receptor complex for Ifn-gamma2 includes cytokine receptor family B (Crfb)6 together with Crfb13 and Crfb17.
zebrafish IFN-gamma1 and IFN-gamma2 are functionally equivalent to mammalian IFN-gamma
Evidence is provided for a pivotal role of group II interferon of zebrafish in the early stages of viral infections, whereas group I interferons exert a slow but more powerful induction of several antiviral and proinflammatory genes.
the identification of a novel isoform of the zebrafish (Danio rerio) IFNGR1 is reported.
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, immune interferon
, interferon gamma
, gamma interferon
, IFN gamma
, interferon gamma type 2
, interferon, gamma
, Interferon gamma
, interferon alpha