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Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl (zeige ABL1 Proteine) transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl (zeige ABL1 Proteine) kinases and p73 (zeige ARHGAP24 Proteine) protein pathway(s).
MARVELD1 (zeige MARVELD1 Proteine) mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development.
Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling.
keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis
Up-regulation of integrin beta4 and TRPV1 (zeige TRPV1 Proteine) in migrating keratinocytes.
Ectopic induction of Nur77 (zeige NR4A1 Proteine) in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 (zeige NR4A1 Proteine) regulates the expression of integrin beta4 by targeting its promoter activity.
Col17a1 (zeige COL17A1 Proteine)/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.
Both annexin A7 (zeige ANXA7 Proteine) and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.
Findings indicate a function for Id2 in regulating Snai1 (zeige SNAI1 Proteine)-mediated repression of integrin beta4.
Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 (zeige TP53 Proteine) and Rb function in a model of prostate cancer (PB-TAg mice).
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (zeige IGF1R Proteine).
MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK (zeige PTK2 Proteine) at Y397 leading to lung cancer cell migration.
a significant reduction in the protein distribution of collagen IV (zeige COL4 Proteine) (P<0.0001), collagen VII (zeige TH Proteine) (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.
For the in vivo experiment, miR (zeige MLXIP Proteine)-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR (zeige MLXIP Proteine)-182-5p may be a key androgen receptor (zeige AR Proteine)-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
data indicate that the beta4 integrin/FAK (zeige PTK2 Proteine) complex and subsequent FAK (zeige PTK2 Proteine) activation are essential regulators during the tumorigenicity of colon cancer
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]
ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (zeige FAM126A Proteine) by conferring anchorage independence through EGFR (zeige EGFR Proteine)-dependent FAK (zeige PTK2 Proteine)-AKT (zeige AKT1 Proteine) activation.
High vimentin and low beta4 integrin protein levels are associated with poor survival in oral squamous carcinoma patients.
Endothelial cell overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
integrin beta 4
, integrin beta-4
, CD104 antigen
, integrin beta-4 subunit