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Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s).
The results of this study suggested that ITGB4 knockout induced chronic inflammation mediated the comorbidity of asthma and bipolar disorder.
he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway.
MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development.
Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling.
keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis
Up-regulation of integrin beta4 and TRPV1 in migrating keratinocytes.
Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity.
Col17a1/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.
Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.
Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4.
Lack of endothelial beta4 integrin had no effect on vascular development, integrity, or endothelial proliferation
Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 and Rb function in a model of prostate cancer (PB-TAg mice).
Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.
aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment
The expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle.
Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions.
Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF
Data show that a previously unrecognized subpopulation of mouse alveolar epithelial cells expressing the laminin receptor alpha6beta4, but little or no pro-surfactant C, is endowed with regenerative potential.
CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion
RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter
High ITGB4 expression is associated with drug resistance in colorectal cancer.
ITGB4 plays a tumorigenic and pro-metastatic role mediated by Slug
N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4
correlation analysis indicated that the expression of ARRDC3 was negatively correlated with ITGbeta4 in clinical prostate cancer (PCa) tissues and cell lines. Our data revealed that ARRDC3 can serve as a tumor suppressor to inhibit PCa progression and an independent marker to predict the risk of biochemical recurrence and metastasis after radical resection of PCa.
ITGB4(+) cancer stem cell (CSC)-enriched mesenchymal cells reside in an intermediate epithelial/mesenchymal phenotypic state.
These findings suggest that the integrin beta4-FAK/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.
Increased integrin alpha6beta4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancers.
a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.
alpha6beta4 integrin is a positive regulator of collective cell migration of A549 cells through influence on signal pathways in leader cells.
For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
data indicate that the beta4 integrin/FAK complex and subsequent FAK activation are essential regulators during the tumorigenicity of colon cancer
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
Herein, we present a female newborn with lethal Junctional epidermolysis bullosa with pyloric atresia caused by a novel beta4 integrin mutation.
analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]
ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC by conferring anchorage independence through EGFR-dependent FAK-AKT activation.
High vimentin and low beta4 integrin protein levels are associated with poor survival in oral squamous carcinoma patients.
Endothelial cell overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression.
integrin alpha6beta4 was indeed involved in dairy cow mammary development.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
integrin beta 4
, integrin beta-4
, CD104 antigen
, integrin beta-4 subunit