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Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases
These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha (zeige HIF1A Proteine) in the EGFR (zeige EGFR Proteine) endocytosis pathway.
crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface
Here they show that the PH domain from Bcr-Abl (zeige ABL1 Proteine) binds a number of proteins involved in vital cellular processes in leukemogenesis.
A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2 (zeige ADRBK1 Proteine)) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 (zeige PRKCB Proteine) and GRK2 (zeige ADRBK1 Proteine).
The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported.
Proteins beta3 integrin (zeige ITGB3 Proteine), Vav3 (zeige VAV3 Proteine), Plekhm1 (zeige PLEKHM1 Proteine), and Src (zeige SRC Proteine), implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis (zeige CSF1 Proteine).
Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4 (zeige HSD17B4 Proteine), alpha-actinin (zeige ACTN1 Proteine), moesin (zeige MSN Proteine), radixin (zeige RDX Proteine) and factor XIIIA (zeige F13A1 Proteine), is proposed.
Targeting of the pleckstrin homology domain of AKT (zeige AKT1 Proteine) was studied in cancer treatment in mouse models.
pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
Major protein kinase C substrate of platelets.
, platelet 47 kDa protein