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Study discovered novel and independent associations of prediabetes and related traits with MASP1 (zeige MASP1 Proteine), and some evidence for associations with THBS1 (zeige THBS1 Proteine), GPLD1 and ApoA-IV (zeige APOA4 Proteine), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.
c-Myc (zeige MYC Proteine) influences GPI (zeige GNPDA1 Proteine)-AP signaling transcriptionally and posttranslational and represses GPI (zeige GNPDA1 Proteine)-AP anti-proliferative signaling in tumors
An observed increase in PLD activity was mediated through boosting the binding of PLD with dynamin (zeige DNM1 Proteine) which in turn facilitated fibronectin (zeige FN1 Proteine)-induced cell spreading.
Low aggressive MCF-7 breast cancer cells have low endogenous PLD enzymatic activity and cell invasion, concomitant with high expression of miR (zeige MLXIP Proteine)-203, -887, and -3619 and miR (zeige MLXIP Proteine)-182 and miR (zeige MLXIP Proteine)-182.
suggest that the down-regulation of GPI-PLD protein may be involved in prion (zeige PRNP Proteine) propagation in the brains of prion (zeige PRNP Proteine) diseases
our findings showed that ANRIL is an lncRNA responsible in anti-tumorigenesis caused by PLD inhibition and combined incorporation of ANRIL into PLD inhibition-induced anti-tumorigenic signaling network
AMPK (zeige PRKAA1 Proteine) suppresses PLD activity, and PLD suppresses AMPK (zeige PRKAA1 Proteine) via mTOR (zeige FRAP1 Proteine).
Functional regulation of phospholipase D expression in cancer and inflammation.
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR (zeige FRAP1 Proteine)).
At the cellular level, PLD and its reaction product, phosphatidate, interact with a large number of protein partners that are directly related to the actin cytoskeleton and cell migration.
Overexpressing GPI-PLD in an insulinoma (zeige RPS15 Proteine) cell line enhanced glucose-stimulated insulin (zeige INS Proteine) secretion, suggesting that enhanced insulin (zeige INS Proteine) secretion in vivo may have contributed to the improved glucose tolerance.
GPI-PLD expression was significantly increased in highly malignant. H-ras (zeige HRAS Proteine)-transfected murine bladder carcinoma cells as compared to the low malignant, non-transfected parental cells.
His29, His125, His133 and His158 are required for GPI-PLD catalytic activity
Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism.
Results suggest that cell-specific Gpld1- or peptidase-dependent pathways for prostasin (zeige PRSS8 Proteine) secretion may control prostasin (zeige PRSS8 Proteine) functions in a tissue-specific manner.
PLD plays an important role in inflammatory responses and could be involved in a mechanism for the regulation of endothelial barrier function during hyperoxic lung injury
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
glycosylphosphatidylinositol specific phospholipase D1
, phosphatidylinositol-glycan-specific phospholipase D-like
, glycosylphosphatidylinositol specific phospholipase d1
, GPI-specific phospholipase D
, PI-G PLD
, glycoprotein phospholipase D
, phosphatidylinositol-glycan-specific phospholipase D
, glycosyl-phosphatidylinositol-specific phospholipase D
, glycosylphosphatidylinositol phospholipase D