Caspase-9 Inhibitor Z-LEHD-FMK

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Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Hersteller Produkt- Nr.
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Verwendungszweck A caspase-9 inhibitor
Sequenz Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 44135217
A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 98 % by HPLC
Chemical Name Z-LEHD-FMK, Caspase-9 Inhibitor, LEHD-fluoromethylketone
Formel C₃₂H₄₃FN₆O₁₀
Permeabilität Cell-permeable
Löslichkeit DMSO
Molekulargewicht 690.7 g/mol
Applikationshinweise Centrifuge the vial prior to opening. We recommend using 1000-5000X dilutions for inhibiting caspase-9 activity in cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
Bilder des Herstellers
 image for Caspase-9 Inhibitor Z-LEHD-FMK (ABIN412392) Caspase-9 Inhibitor Z-LEHD-FMK
Produkt verwendet in: Ying, Yang, Tsai, Hsieh, Huang, Bau, Hsieh: "Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway." in: Archives of toxicology, 2011 (PubMed).

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Song, Zhou, Kim, Shapiro, Liu, Ferran, Choi, Otterbein: "Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44327-34, 2004 (PubMed).

Wang, Grégori, Hullinger, Andrisani et al.: "Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor ..." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10352-65, 2004 (PubMed).

Morishima, Nakanishi, Takenouchi, Shibata, Yasuhiko: "An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34287-94, 2002 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Chatterjee, Brite, Matsumura: "Induction of apoptosis of integrin-expressing human prostate cancer cells by cyclic Arg-Gly-Asp peptides." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 10, pp. 3006-11, 2001 (PubMed).