Caspase-1 Inhibitor Z-YVAD-FMK

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Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Hersteller Produkt- Nr.
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Verwendungszweck A caspase-4 inhibitor
Sequenz Z-Tyr-Val-Ala-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 16760349
A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 99 % by HPLC
Chemical Name Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Formel C₃₁H₃₉FN₄O₉
Permeabilität Cell-permeable
Löslichkeit DMSO
Molekulargewicht 630.7 g/mol
Applikationshinweise We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 6-12 months
Bilder des Herstellers
 image for Caspase-1 Inhibitor Z-YVAD-FMK (ABIN412351) Caspase-1 Inhibitor Z-YVAD-FMK
Produkt verwendet in: Lhomme, Esser, Riva, Scheen, Paquot, Piette, Legrand-Poels: "Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages." in: Journal of lipid research, Vol. 54, Issue 11, pp. 2998-3008, 2013 (PubMed).

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Hewinson, Moore, Glover, Watts, MacKenzie: "A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8410-20, 2008 (PubMed).

Arai, Miyake, Voit, Nemoto, Wakeland, Grummt, Miyazaki: "Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2289-94, 2007 (PubMed).

Cruz, Rinna, Forman, Ventura, Persechini, Ojcius: "ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2871-9, 2007 (PubMed).

Klumpp, Rycyk, Chen, Thumbikat, Sengupta, Schaeffer: "Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis." in: Infection and immunity, Vol. 74, Issue 9, pp. 5106-13, 2006 (PubMed).

Lin, Cheung, Wu, Chen, Lin, Chen, Liou, Shyue, Wu: "15d-prostaglandin J2 protects brain from ischemia-reperfusion injury." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 3, pp. 481-7, 2006 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).