Details zu Produkt Nr. ABIN412289, Anbieter: Anmelden zum Anzeigen
Cell Culture (CC), Functional Studies (Func)
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Verwendungszweck An AMPK activator
Produktmerkmale A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
Reinheit ≥ 98 % by HPLC
Chemical Name 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AICA-Riboside; NSC 105823
Formel C₉H₁₄N₄O₅
Permeabilität Cell-permeable
Molekulargewicht 258.23 g/mol
CAS-Nummer 2627-69-2
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Powder
Handhabung Protect from air and moisture
Lagerung -20 °C
Haltbarkeit 24 months
Bilder des Herstellers
 image for AICAR (ABIN412289) AICAR
 image for AICAR (ABIN412289) AICAR (Image 2)
Produkt verwendet in: Adamo, Zhang, García-Cardeña: "AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts." in: BMC pharmacology, Vol. 9, pp. 2, 2009 (PubMed).

Hayashi, Hirshman, Kurth, Winder, Goodyear: "Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport." in: Diabetes, Vol. 47, Issue 8, pp. 1369-73, 1998 (PubMed).