ATM Kinase Inhibitor, KU-55933

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Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck An ATM kinase inhibitor
Produktmerkmale A potent, selective and ATP-competitive inhibitor of Atm Kinase (Ki = 2.2 nM, IC50 = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC50 = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
Reinheit ≥ 97 % by HPLC
Chemical Name 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
Formel C₂₁H₁₇NO₃S₂
Permeabilität Cell-permeable
Löslichkeit DMSO (100 mM) and Ethanol (50 mM)
Molekulargewicht 395.49 g/mol
CAS-Nummer 587871-26-9
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid
Handhabung Protect from air and light
Lagerung -20 °C
Haltbarkeit 24 months
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 image for ATM Kinase Inhibitor, KU-55933 (ABIN412287) ATM Kinase Inhibitor, KU-55933
Produkt verwendet in: DeLoughery, Luczak, Ortega-Atienza, Zhitkovich: "DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 54-63, 2014 (PubMed).