Caspase-13 Inhibitor LEED-FMK

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Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A caspase-13 inhibitor
Sequenz Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK
Produktmerkmale PubChem CID: 44135223
A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Reinheit > 95 % by HPLC
Chemical Name Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone)
Formel C₃₂H₄₅FN₄O₁₂
Permeabilität Cell-permeable
Löslichkeit In DMSO (10 mM)
Molekulargewicht 696.7 g/mol
Applikations-hinweise We recommend using 1000-5000X dilutions for inhibiting caspase-13 and related caspase activity (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary among different cells and culture conditions. The inhibitor is designed as a methyl ester to facilitate cell permeability.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 10 mM
Handhabung Protect from light and moisture
Lagerung -20 °C
Haltbarkeit 12 months
Produkt verwendet in: Bian, Sun, Silver, Ho, Marchionni, Caggiano, Stone, Amende, Hampton, Morgan, Yan: "Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins." in: American journal of physiology. Heart and circulatory physiology, Vol. 297, Issue 6, pp. H1974-83, 2009 (PubMed).