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Our results...highlight the neuropeptide FF-amide peptide encoding gene (NPFF) as a novel candidate risk gene for both migraine with aura (zeige AURKA Antikörper) and migraine without aura (zeige AURKA Antikörper)
reduction of NPFF release within the dorsal motor nucleus and ambiguus nucleus could serve as a possible cause of the impairment of cardiac vagal control in hypertensive patients
expression of hNPFF2 receptor mRNA was up-regulated by neuropeptide FF
neuropeptide FF and micro-opioid receptor association could be a possible molecular basis for anti-opioid activity
the findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation--review
NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial adipose tissue macrophages.
findings suggest that the suppressive signalling of RFRP-3 on Gonadotrophin releasing hormone transcription may dominate over kisspeptin induction in the mHypoA-GnRH/GFP Gonadotrophin releasing hormone neuronal cell model.
Down-regulation of nitric oxide (NO) synthases (NOSs) partially significantly inhibited the viability augmentation of macrophages induced by Npff, implying a nitric oxide synthases- dependent pathway is involved.
RF-amide-related peptide-3 (RFRP (zeige NPVF Antikörper)-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 (zeige NPFFR1 Antikörper) receptor (NPFF1R) to repress the reproductive axis.
RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH.
Interaction between GnRH I (zeige GNRH1 Antikörper)-RFRP (zeige NPVF Antikörper)-3 neuropeptides may be involved in the regulation of follicular development and atresia.
It is concluded that aging mice exhibits inverse correlation of RFRP (zeige NPVF Antikörper)-3 neurons and gonadal activity suggesting that function of RFRP (zeige NPVF Antikörper)-3 is not initiated until 1-week of age and thereafter it could participate in the regulation of gonadal development.
results demonstrate a small but complex influence of the NPFF system on mouse behavior
We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are likely transcriptional regulators of NPFF gene expression.
Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice.
RFamide-related peptide (zeige NPVF Antikörper)-3 octapeptide suppresses luteinizing hormone (LH) secretion from cultured anterior pituitary cells, as well as LH pulse frequency in cattle.
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function.
, RFamide-related peptide
, RFamide related peptide