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LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells
High LY6E expression is associated with breast cancer.
LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance.
LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication.
LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis.
the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention.
This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china.
Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients.
Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease.
Knocking down Ly6e greatly reduced SynA-induced cell fusion, thus suggesting that Ly6e is the sole receptor for SynA in vivo.
Sca-2 -- a signal transducer situated at the nexus of surface molecules regulating death receptor-mediated apoptosis in hepatoma
Involved in T-cell development.
lymphocyte antigen 6 complex, locus E
, lymphocyte antigen 6E
, retinoic acid induced gene E
, retinoic acid-induced gene E protein
, stem cell antigen 2
, thymic shared antigen 1