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anti-Human Interleukin 6 Antikörper:
anti-Mouse (Murine) Interleukin 6 Antikörper:
anti-Rat (Rattus) Interleukin 6 Antikörper:
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Human Monoclonal Interleukin 6 Primary Antibody für FACS - ABIN1383944
Lu, Brochier, Wijdenes, Brailly, Bataille, Klein: High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. in European journal of immunology 1992
Show all 60 Pubmed References
Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody für WB - ABIN3042620
Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage. in Journal of cellular biochemistry 2011
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Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody für ELISA, WB - ABIN3043248
Liu, Shan, Dong, Liu, Ma, Liu: Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. in World journal of gastroenterology 2013
Show all 27 Pubmed References
Human Polyclonal Interleukin 6 Primary Antibody für WB - ABIN3043090
Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes. in Natural products and bioprospecting 2015
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Rat (Rattus) Polyclonal Interleukin 6 Primary Antibody für WB - ABIN3042526
Shi, Song, Zhang, Li, Li: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. in Experimental and therapeutic medicine 2013
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Human Polyclonal Interleukin 6 Primary Antibody für WB - ABIN3042806
Chen, Zhao, Wu, Zou, Luo, Li, Xie, Liang: The role of RIP1 and RIP3 in the development of aplastic anemia induced by cyclophosphamide and busulphan in mice. in International journal of clinical and experimental pathology 2015
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Human Polyclonal Interleukin 6 Primary Antibody für ICC, IF - ABIN269335
Bottino, Balamurugan, Tse, Thirunavukkarasu, Ge, Profozich, Milton, Ziegenfuss, Trucco, Piganelli: Response of human islets to isolation stress and the effect of antioxidant treatment. in Diabetes 2004
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Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody für ELISA, WB - ABIN5693120
Wan, Ma, Mei, Shan: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. in Journal of experimental & clinical cancer research : CR 2010
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Human Monoclonal Interleukin 6 Primary Antibody für CyTOF, FACS - ABIN4900155
Maneechotesuwan, Wamanuttajinda, Kasetsinsombat, Huabprasert, Yaikwawong, Barnes, Wongkajornsilp: Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. in The Journal of allergy and clinical immunology 2009
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Mouse (Murine) Polyclonal Interleukin 6 Primary Antibody für IF (p), IHC (p) - ABIN728083
Sun, Zeng, Cao, Song, Zhang, Liu: Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue. in BioMed research international 2015
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we review the role of IL-6/JAK/STAT3 signalling in the tumour microenvironment and the status of preclinical and clinical investigations of agents targeting this pathway. We also discuss the potential of combining IL-6/JAK/STAT3 inhibitors with currently approved therapeutic agents directed against immune-checkpoint inhibitors.
IL6 gene polymorphisms are significantly associated with the increased risk of endometrial cancer in Hainan Chinese Han women.
TNF has a role in stimulating IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin
Study found that COX1 and COX2 contribute to early solar ultraviolet irradiation (UVR) induction of IL-6, but not TNF-alpha or IL-1beta, in human skin. Present study was the first to directly investigate the role of COXs in UVR-induced cytokine productions in humans.
Plasmatic doses of acetylsalicylic acid and celecoxib altered the expression of IL6 and the gene expression of chemokines (ligands and receptors) and cytokines in a dose- and time-dependent manner.
The -174 G/G IL-6 genotype increases the risk of developing tuberculosis and type 2 diabetes mellitus comorbidity and this risk is raised when associated with -308G/G TNF-alpha.
adipocyte-derived IL-6 and leptin promote PLOD2 expression by activating the JAK/STAT3 and PI3K/AKT signaling pathways
The study found no significant differences between Takayasu arteritis and healthy controls in the frequency of any of the variations in the SNPs of IL-6 and IL-10 genes. The expression levels of both cytokines were associated with the disease status, indicating that they may serve as potential biomarkers for monitoring disease activity.
Obese patients with peripheral neuropathy had higher values of serum IL-6 and hs-CRP than diabetic patients without diabetic peripheral neuropathy.
High IL6 expression is associated with early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation.
This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case-control studies are needed to confirm these results.
Maternal IL-6 also directly accounts for a portion of the variance of working memory at 2 years of age
Constitutive activation of phosphatase SHP2 was found to negatively regulate IL-6 induced STAT3 phosphorylation in fibroblasts from severe asthmatics.
Combination of IL-33/IL-6 had a synergistic effect.
these findings show that IL-6 and CCL5 signaling, which promote crosstalk between triple-negative breast cancer (TNBC) and lymphatic vessels, are key enhancers of TNBC tumor growth and metastasis. Furthermore, these results demonstrate that a drug combination inhibiting these pathways may be a promising therapy for TNBC patients
IL6 expression is regulated by miR-26a in ambient particulate matter-bound metal-triggered lung cancer.
regulation of IL-6 levels during psoriasis by let-7b
molecular differences in IL-6 classic- and trans-signaling in human vascular endothelial cells
CRP, IL-6 and procalcitonin are applicable to the differential diagnosis of sepsis and differentiating the sepsis induced by Gram-negative bacteria from Gram-positive bacteria.
Our findings support an important role for TGFB1 and IL-6 in the onset and development of DDH, though this significant SNP cannot serve as an indicator of DDH severity.
miR-151-3p inhibited lipopolysaccharide-induced IL-6 production by targeting Stat3.
NEU1/3 activity mediates IL-6 production in lupus-prone mesangial cells possibly through an IgG-receptor complex signaling pathway.
our findings provide evidence that increased spinal cord CALP2 and microglia cell activation may have early causative roles in IL-6 over-expression following motor nerve injury
Denervation-activated fibro-adipogenic progenitors exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis.
chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle.
this study shows that donor IL-6 deficiency evidently reduces memory T cell responses in sensitized transplant recipients
IL-6 trans-signalling inhibition prevented the increase in osteoclasts, and trabecular bone loss, associated with ovariectomy.
Data indicate that calcium flux, rather than the contraction itself, triggered contraction-induced interleukin-6 (IL-6) secretion.
inhibition of IL-6 trans-signaling increased the evoked glutamate release in synaptoneurosomes from the cerebral cortex of BTBR mice. Our findings suggest that inhibition of excessive production of IL-6 may have selective therapeutic efficacy in treating abnormal social behaviors in autism.
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent macrophage polarization.
High IL6 expression is associated with angiogenesis in B16 melanoma.
results showed elevated expression of Syk in neutrophils and CD11c + DC which was linked with increased IL-6/MCP-1 in CD11c + DCs, and iNOS, NOX2 and nitrotyrosine in neutrophils during sepsis-induced acute kidney injury.
The results define a new role of IL-6 signaling in macrophage polarization downstream of tumor necrosis factor. IL-6 could be involved in M2 macrophage differentiation.
results demonstrate that IL-6 signalling mediates the Gal-8 immune-stimulatory effect.
These results strongly suggest that HSP22 interacts with mTOR and regulates TNF-alpha-induced IL-6 synthesis in osteoblasts.
We detected the alteration of IL6 expression as a regulator of superoxide dismutase in addition to several extracellular matrix proteins in an Alzheimer's disease mouse model. There could be an important relationship between IL6, CA1 extracellular region proteins, and iron.
Tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 were upregulated during BCG infection but downregulated by Rv2346c.
distinct roles for OSM and IL-6 in M2 macrophage polarization, are reported.
elevated S1P, coupled with macrophage S1PR1 reciprocally inducing IL-6 expression, is a key signaling network functioning as a malicious, positive, feed-forward loop to sustain inflammation and promote tissue damage in sickle cell disease.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt signaling pathway transactivator beta-catenin, induced expression of inhibitors of the Wnt pathway, and increased expression of GDF-5.
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR activation and that this effect can be modulated by A2AAR
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.
this study shows of IL-6 to the form of post-traumatic osteoarthritis induced by "idealized" anterior cruciate ligament reconstruction in a porcine model
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (signal transducer/activator of transcription 3) signaling pathway (including up-regulation of STAT3 expression/phosphorylation).
LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1, and apoptotic Bak and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
a parameter of early mRNA expression during intestinal ischemia reperfusion injury
These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
possible that IL-6 is produced in the granulosa cells of healthy follicles, that it increases the cFLIP(L) level, and cFLIP(L) then prevents apoptotic cell death
There is a direct link between IL-6 and ACTH release a sex difference in this relationship in stress
The data indicate that the development of clinical symptoms of coliform mastitis in the sow is associated with a locally increased proinflammatory cytokine production in response to intramammary Escherichia coli infection.
Eight polymorphisms in the IL6 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha and IL-6/sIL-6R in causing proteoglycan degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12), are potent inducers of IL-1beta and IL-6 gene expression and were equal to, or more potent than, crude LPS.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)