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ActRIIB mRNA but not protein was decreased in skeletal muscle of obese compared with lean animals.
the A allele of genetic variant rs2276541 in ACVR2B is associated with lean muscle mass
TGF-beta (zeige TGFB1 Proteine) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
ActR-IIB is expressed in male germ cells and Sertoli cells.
Activin A (zeige INHBA Proteine) inhibited signaling by BMP-6 (zeige BMP6 Proteine) and BMP-9 (zeige GDF2 Proteine) by competing for type 2 receptors ACVR2A (zeige ACVR2A Proteine) and ACVR2B.
We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19.
miR (zeige MLXIP Proteine)-21 interacts directly with the 3'-untranslated region of ACVR2B mRNA. Mechanical stretch suppressed ACVR2B protein levels in periodontal ligament stem cells. Gain- and loss of function of ACVR2B mediated the osteogenic differentiation of PDLSCs.
Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
Activin type IIB receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain.
After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed lower levels of ActRIIb while postmenopausal women using HT showed a heightened response.
The interaction between all five miRNAs and ACVR2B was verified by an in vitro assay.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
The endoplasmic reticulum stress stress and unfolded protein response are increased in mdx (zeige DMD Proteine) muscle. However, these processes are not distinctly improved by voluntary exercise or blocking activin receptor IIB ligands and thus do not appear to be optimal therapeutic choices for improving proteostasis in Duchenne muscular dystrophy (zeige DMD Proteine).
Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A (zeige ACVR2A Proteine) exhibit un-characteristic features; osteoclasts deficient in Acvr2A (zeige ACVR2A Proteine) or Acvr2B or both appear normal. Acvr2A (zeige ACVR2A Proteine)-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter.
Differential muscle hypertrophy is associated with satellite cell numbers and Akt (zeige AKT1 Proteine) pathway activation following activin type IIB receptor inhibition in Mtm1 (zeige MTM1 Proteine)
ActRIIB inhibition enhanced energy expenditure only at ambient temperature or in the cold, where nonshivering thermogenesis is minimal, suggesting that brown fat activation plays a prominent role in the metabolic actions of ActRIIB inhibition.
findings best fit a model in which BMP3 (zeige BMP3 Proteine), produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts
Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II (zeige BMPR2 Proteine) and ActR-IIB.
Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin (zeige MTM1 Proteine)-deficient mice.
Akt (zeige AKT1 Proteine) isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function .
ActRIIB plays a role in the specification of left-sidedness in developing mice
Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA (zeige ACVR2A Proteine)), cooperatively mediate the Gdf11 (zeige GDF11 Proteine) signal in patterning the axial vertebrae
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
activin A receptor, type IIB
, activin receptor type IIB
, activin receptor type-2B-like
, activin type IIB receptor
, activin receptor type-2B
, testicular activin receptor IIB
, ActRIIB type II activin receptor B
, Activine receptor 2b (transmembrane serine kinase)
, activin receptor IIB