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Cow (Bovine) Polyclonal ABCC2 Primary Antibody für WB - ABIN610784
Cockcroft, Thomas, Fensome, Geny, Cunningham, Gout, Hiles, Totty, Truong, Hsuan: Phospholipase D: a downstream effector of ARF in granulocytes. in Science (New York, N.Y.) 1994
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Polymorphisms of GSTP1 (zeige GSTP1 Antikörper) rs1695 and ABCC2 rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy. Kaplan-Meier survival analysis indicated that survival with GSTP1 (zeige GSTP1 Antikörper) AG+ GG was significantly longer than in patients with AA gene (P<0.05), and survival with ABCC2 CT + TT was significantly longer than in patients with CC gene.
Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 c.-24C>T and ABCB1 (zeige ABCB1 Antikörper) p.Ser893Ala/Thr (zeige TRH Antikörper) and in DNA repair machinery ERCC2 (zeige ERCC2 Antikörper) p.Lys751Gln.
Self-inhibition of the MRP2-dependent secretion of MTX (zeige MTX1 Antikörper) is a plausible explanation for the time-dependent PKs of this drug.
SMS (zeige SMS Antikörper) regulates the expression and function of drug transporters P-gp (zeige ABCB4 Antikörper) and MRP2.
genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed.
BCRP and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.
Four SNPs within the APOE (zeige APOE Antikörper) cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1 (zeige SORT1 Antikörper)/PSRC1 (zeige PSRC1 Antikörper) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (zeige LIPA Antikörper)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.
In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions
ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase.
Biotinylation and streptavidin pull-down assays confirmed that CAL (zeige S100A11 Antikörper) dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL (zeige S100A11 Antikörper) interacts with Mrp2 and is a negative regulator of Mrp2 expression.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (zeige ABCC1 Antikörper) and Mrp2, in WT cells but not in metallothionein (zeige MT Antikörper)-null cells.
hepatic transporters Ntcp (zeige SLC10A1 Antikörper) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Both Abcc2 and Abcc3 (zeige ABCC3 Antikörper) significantly influenced the PK properties of MTX (zeige MTX1 Antikörper).
hyperosmotic cholestasis is triggered by a NADPH oxidase (zeige NOX1 Antikörper)-driven reactive oxygen species formation that mediates Fyn (zeige FYN Antikörper)-dependent retrieval of the Mrp2 and Bsep (zeige ABCB11 Antikörper) from the canalicular membrane, which may involve an increased cortactin (zeige CTTN Antikörper) phosphorylation.
Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan
In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2